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Respiratory, allergy and digestive drugs

Doxofylline

Also known as Doxophylline, Dioxyfilline, Ansimar

CAS 69975-86-6Formula C11H14N4O4Molar mass 266.26 g/molEC 274-239-6
GHS signal word: Warning. Pictograms: Harmful or irritant 60 suppliers listed
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Doxofylline chemical structure, C11H14N4O4, CAS 69975-86-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
69975-86-6
Formula
C11H14N4O4
Molar mass
266.26 g/mol
EC number
274-239-6
HS code
293959
Category
Respiratory, allergy and digestive drugs

What is Doxofylline?

Plain description, key identifiers and synonyms

Doxofylline is an oxopurine that is a derivative of xanthine, methylated at N-1 and N-3 and carrying a 1,3-dioxolan-2-ylmethyl group at N-7, used in the treatment of asthma. It has a role as a bronchodilator agent, an anti-asthmatic drug and an antitussive. It is functionally related to a 7H-xanthine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione
CAS number
69975-86-6 CAS number cross-checked
EC number
274-239-6
Molecular formula
C11H14N4O4
UNII
MPM23GMO7Z
MDL number
MFCD00865218
InChIKey
HWXIGFIVGWUZAO-UHFFFAOYSA-N
InChI
InChI=1S/C11H14N4O4/c1-13-9-8(10(16)14(2)11(13)17)15(6-12-9)5-7-18-3-4-19-7/h6-7H,3-5H2,1-2H3
SMILES (canonical and isomeric)
CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC3OCCO3

Synonyms

  • Doxophylline
  • Dioxyfilline
  • Ansimar
  • Ventax
  • Doxofilina
  • Doxofyllinum
  • Synasma
  • ABC 12/3
  • 7-(1,3-Dioxolan-2-ylmethyl)theophylline
  • 1H-Purine-2,6-dione, 7-(1,3-dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-
  • TMDO
  • 7-[(1,3-dioxolan-2-yl)methyl]-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
  • doxofillina
  • 2-(7'-theophyllinemethyl)1,3-dioxolane
  • 7-((1,3-dioxolan-2-yl)methyl)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
  • Maxivent
  • 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione
  • 7-((1,3-dioxolan-2-yl)methyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
  • 7-(1,3-dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dione
  • 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-purine-2,6-dione
  • 7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethyl-1H-purine-2,6-dione
  • 7-((1,3-dioxolan-2-yl)methyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
  • 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
  • 2-(7'-Theophyllinemethyl)-1,3-dioxolane
  • Ansimar,
Show all 31 synonyms
  • 7-[(1,3-Dioxolan-2-yl)methyl]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
  • Maxivent (TN)
  • 2-(7'-Teofillinmetil)-1,3-diossolano
  • Doxofylline (Standard)
  • Doxofylline (USAN/INN)
  • Theophylline, 7-(1,3-dioxolan-2-ylmethyl)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
266.26 g/molcalc.
Exact mass
266.1015 Dacalc.
LogP (octanol/water)
-1.19calc.
Topological polar surface area
80.28 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
19calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.55calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1[nH]c(=O)c2c(ncn2CC2OCCO2)[nH]1

O=c1[nH]c(=O)c2c(ncn2CC2OCCO2)[nH]1

3 rings, 17 atoms.

5 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
Precautionary statements (13)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Doxofylline suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 60 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

60 suppliers in 12 countries

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Doxofylline price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antitussive Agents
  • Bronchodilator Agents
  • Phosphodiesterase Inhibitors

Roles

  • anti-asthmatic agent
  • anti-asthmatic drug
  • antitussive
  • bronchodilator agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Doxofylline is traded under.

HS 2939.59Indicative HS code

Theophylline and aminophylline (theophylline-ethylenediamine) and their derivatives…

World exports in 2024
$56M
+6.9% vs 2023, imports $62.2M
2019 to 2024
Top exporters
  1. India * partner reported46.2%
  2. China22.9%
  3. Italy14.5%
Top importers
  1. United States10.4%
  2. Italy9.2%
  3. South Korea7.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Doxofylline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Doxofylline, based on the data on this page

What is Doxofylline?

Doxofylline is an oxopurine that is a derivative of xanthine, methylated at N-1 and N-3 and carrying a 1,3-dioxolan-2-ylmethyl group at N-7, used in the treatment of asthma. It has a role as a bronchodilator agent, an anti-asthmatic drug and an antitussive. It is functionally related to a 7H-xanthine.

What is the CAS number of Doxofylline?

The CAS registry number of Doxofylline is 69975-86-6.

What is the molecular formula and weight of Doxofylline?

The molecular formula of Doxofylline is C11H14N4O4 and its molar mass is 266.26 g/mol.

What is Doxofylline used for?

Known uses and roles of Doxofylline include respiratory and anti-allergy drugs in pharmaceuticals, anti-asthmatic agent, anti-asthmatic drug, antitussive, bronchodilator agent and 4 more.

Is Doxofylline hazardous?

Doxofylline carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Doxofylline?

Doxofylline is usually classified under HS code 293959 (Theophylline and aminophylline (theophylline-ethylenediamine) and their derivatives…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Doxofylline?

CompoundList lists 60 suppliers of Doxofylline in India, China, Bangladesh, United States and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Doxofylline in India?

21 suppliers in India list Doxofylline on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Doxofylline?

Suppliers quote Doxofylline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Doxofylline

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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