CompoundList
Sign in
Central nervous system drugs

Droxidopa

Also known as L-DOPS, DOPS, (2S,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid

CAS 23651-95-8Formula C9H11NO5Molar mass 213.19 g/molEC 223-480-5
GHS signal word: Warning. Pictograms: Harmful or irritant 70 suppliers listed Drug substance
Get quotes Compare 70 suppliers
Droxidopa chemical structure, C9H11NO5, CAS 23651-95-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
23651-95-8
Formula
C9H11NO5
Molar mass
213.19 g/mol
EC number
223-480-5
HS code
292250
Category
Central nervous system drugs

What is Droxidopa?

Plain description, key identifiers and synonyms

Droxidopa is a serine derivative that is L-serine substituted at the beta-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension. It has a role as an antihypertensive agent, a prodrug and a vasoconstrictor agent. It is a L-tyrosine derivative and a member of catechols.

Droxidopa is a synthetic amino acid precursor acting as a prodrug to the neurotransmitter norepinephrine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid
CAS number
23651-95-8 CAS number cross-checkedOther or deprecated CAS: 1260173-94-1, 3916-18-5
EC numbers
223-480-5, 688-528-3
Molecular formula
C9H11NO5
UNII
24A0V01WKS, J7A92W69L7
MDL number
MFCD00799030
InChIKey
QXWYKJLNLSIPIN-JGVFFNPUSA-N
InChI
InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1
Canonical SMILES
NC(C(=O)O)C(O)c1ccc(O)c(O)c1
Isomeric SMILES
C1=CC(=C(C=C1[C@H]([C@@H](C(=O)O)N)O)O)O

Synonyms

  • L-DOPS
  • DOPS
  • (2S,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid
  • Northera
  • threo-Dopaserine
  • L-threo-DOPS
  • L-Threodops
  • L-dihydroxyphenylserine
  • droxidopum
  • SM 5688
  • L-threo-dihydroxyphenylserine
  • L-Tyrosine, beta,3-dihydroxy-, threo-
  • threo DOPS
  • threo-DOPS
  • (-)-(2S,3R)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid
  • 3,4 threo DOPS
  • 3,4-threo-DOPS
  • 3,4 Dihydroxyphenylserine
  • erythro 3,4 Dihydroxyphenylserine
  • DL threo 3,4 Dihydroxyphenylserine
  • DL-threo-Droxidopa
  • DL-threo-3,4-Dihydroxyphenylserine
  • DL-threo-DOPS
  • DL-threo-Dihydroxyphenylserine
  • Threo-dihydroxyphenylserine
Show all 37 synonyms
  • L-threo-Droxidopa
  • (betaR)-beta,3-dihydroxy-L-tyrosine
  • L-threo 3,4-Dihydroxyphenylserine
  • Serine, 3-(3,4-dihydroxyphenyl)-, DL-threo-
  • L-Tyrosine, beta,3-dihydroxy-, (betaR)-
  • L-threo-3,4-dihydroxyphenylserine
  • Droxydopa
  • Droxidopa pound L-DOPS pound(c)
  • Norethra
  • threo-beta,3-Dihydroxy-DL-tyrosine
  • beta,3-Dihydroxy-DL-tyrosine threo-
  • L-DOPS, DOPS, SM5688

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
213.19 g/molcalc.
Exact mass
213.0637 Dacalc.
LogP (octanol/water)
-0.46calc.
Topological polar surface area
124 Ųcalc.
Hydrogen bond donors
5calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
3calc.
Heavy atoms
15calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.22calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Droxidopa suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 70 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

70 suppliers in 15 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Droxidopa price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Antiparkinson Agents

Roles

  • antidyskinesia agent
  • antihypertensive agent
  • antiparkinson drug
  • cardiovascular drug
  • pharmaceutical
  • pro-agent
  • prodrug
  • vasoconstrictor agent

Pharmacology

The physiologic effect of droxidopa is by means of Increased Blood Pressure.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Droxidopa is traded under.

HS 2922.50Indicative HS code

Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function

World exports in 2024
$3.29B
−5.9% vs 2023, imports $3.19B
2019 to 2024
Top exporters
  1. China39.2%
  2. United Kingdom27.1%
  3. India * partner reported4.8%
Top importers
  1. United States20.7%
  2. Germany7.6%
  3. Italy6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Droxidopa is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Droxidopa, based on the data on this page

What is Droxidopa?

Droxidopa is a serine derivative that is L-serine substituted at the beta-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension. It has a role as an antihypertensive agent, a prodrug and a vasoconstrictor agent.

What is the CAS number of Droxidopa?

The CAS registry number of Droxidopa is 23651-95-8. Other or deprecated CAS numbers: 1260173-94-1, 3916-18-5.

What is the molecular formula and weight of Droxidopa?

The molecular formula of Droxidopa is C9H11NO5 and its molar mass is 213.19 g/mol.

What is Droxidopa used for?

Known uses and roles of Droxidopa include cns agents in pharmaceuticals, antidyskinesia agent, antihypertensive agent, antiparkinson drug, cardiovascular drug and 5 more.

Is Droxidopa hazardous?

Droxidopa carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Droxidopa?

Droxidopa is usually classified under HS code 292250 (Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Droxidopa?

CompoundList lists 70 suppliers of Droxidopa in United States, China, India, United Kingdom and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Droxidopa in India?

10 suppliers in India list Droxidopa on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Droxidopa?

Suppliers quote Droxidopa on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Droxidopa

Get quotes for Droxidopa

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Droxidopa
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Droxidopa with a 3D view, its CAS number and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/droxidopa-23651-95-8" title="Droxidopa structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Central nervous system drugs or HS code 292250

70 suppliers
Free quotes, contact stays private
Get quotes