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Screening compounds

Edaxeterkib

Also known as Example 104, (-)-(R)-6-(1-Benzylpiperidin-3-yl)-3-(2-methoxypyrimidin-5-yl)-1,5,6,8-tetrahydro-7H-pyrazolo(4,3-g)quinazolin-7-one, 7H-Pyrazolo(4,3-g)quinazolin-7-one, 1,5,6,8-tetrahydro-3-(2-methoxy-5-pyrimidinyl)-6-((3R)-1-(phenylmethyl)-3-piperidinyl)-

CAS 1695534-88-3Formula C26H27N7O2Molar mass 469.55 g/mol
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Edaxeterkib chemical structure, C26H27N7O2, CAS 1695534-88-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1695534-88-3
Formula
C26H27N7O2
Molar mass
469.55 g/mol
HS code
293359
Category
Screening compounds

What is Edaxeterkib?

Plain description, key identifiers and synonyms

Edaxeterkib is an inhibitor of the extracellular signal-regulated kinases (ERK) 1 and 2, with potential antineoplastic activity. Upon intravenous administration, edaxeterkib specifically binds to and inhibits both ERK 1 and 2, thereby preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The MAPK/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in the proliferation, differentiation and survival of tumor cells.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6-[(3R)-1-benzylpiperidin-3-yl]-3-(2-methoxypyrimidin-5-yl)-5,8-dihydro-1H-pyrazolo[4,5-g]quinazolin-7-one
CAS number
1695534-88-3
Molecular formula
C26H27N7O2
UNII
D9F5G5D3GN
InChIKey
SQNCXVDXNAUREB-HXUWFJFHSA-N
InChI
InChI=1S/C26H27N7O2/c1-35-25-27-12-19(13-28-25)24-21-10-18-15-33(26(34)29-22(18)11-23(21)30-31-24)20-8-5-9-32(16-20)14-17-6-3-2-4-7-17/h2-4,6-7,10-13,20H,5,8-9,14-16H2,1H3,(H,29,34)(H,30,31)/t20-/m1/s1
SMILES
COC1=NC=C(C=N1)C2=NNC3=C2C=C4CN(C(=O)NC4=C3)[C@@H]5CCCN(C5)CC6=CC=CC=C6

Synonyms

  • Example 104
  • (-)-(R)-6-(1-Benzylpiperidin-3-yl)-3-(2-methoxypyrimidin-5-yl)-1,5,6,8-tetrahydro-7H-pyrazolo(4,3-g)quinazolin-7-one
  • 7H-Pyrazolo(4,3-g)quinazolin-7-one, 1,5,6,8-tetrahydro-3-(2-methoxy-5-pyrimidinyl)-6-((3R)-1-(phenylmethyl)-3-piperidinyl)-
  • Example 104 (WO2015051341A1)
  • 6-((3R)-1-Benzylpiperidin-3-yl)-3-(2-methoxypyrimidin-5-yl)-1,5,6,8-tetrahydro-7H-pyrazolo(4,3-g)quinazolin-7-one
  • 6-((3R)-1-Benzylpiperidin-3-yl)-3-(2-methoxypyrimidin-5-yl)-1,5,6,8- tetrahydro-7H-pyrazolo(4,3-g)quinazolin-7-one
  • 6-[(3R)-1-benzylpiperidin-3-yl]-3-(2-methoxypyrimidin-5-yl)-5,8-dihydro-1H-pyrazolo[4,3-g]quinazolin-7-one
  • KO 947
  • 6-[(3R)-1-benzylpiperidin-3-yl]-3-(2-methoxypyrimidin-5-yl)-5,8-dihydro-1H-pyrazolo[4,5-g]quinazolin-7-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
469.55 g/molcalc.
Exact mass
469.2226 Dacalc.
LogP (octanol/water)
4.04calc.
Topological polar surface area
99.27 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
5calc.
Heavy atoms
35calc.
Rings
6calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.31calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1Nc2cc3[nH]nc(-c4cncnc4)c3cc2CN1C1CCCN(Cc2ccccc2)C1

O=C1Nc2cc3[nH]nc(-c4cncnc4)c3cc2CN1C1CCCN(Cc2ccccc2)C1

6 rings, 33 atoms.

No other chemical in our database has this scaffold.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Edaxeterkib suppliers

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Edaxeterkib price

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Edaxeterkib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Edaxeterkib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Edaxeterkib, based on the data on this page

What is Edaxeterkib?

Edaxeterkib is an inhibitor of the extracellular signal-regulated kinases (ERK) 1 and 2, with potential antineoplastic activity.

What is the CAS number of Edaxeterkib?

The CAS registry number of Edaxeterkib is 1695534-88-3.

What is the molecular formula and weight of Edaxeterkib?

The molecular formula of Edaxeterkib is C26H27N7O2 and its molar mass is 469.55 g/mol.

What is Edaxeterkib used for?

Known uses and roles of Edaxeterkib include building blocks in research and laboratory and screening compounds in research and laboratory.

Is Edaxeterkib hazardous?

No GHS hazard classification for Edaxeterkib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Edaxeterkib?

Edaxeterkib is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Edaxeterkib?

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What is the price of Edaxeterkib?

Suppliers quote Edaxeterkib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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