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Screening compounds

Eltrombopag

Also known as (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid, Eltrombopag-Isomer, SB 497115

CAS 496775-61-2Formula C25H22N4O4Molar mass 442.48 g/mol
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Eltrombopag chemical structure, C25H22N4O4, CAS 496775-61-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
496775-61-2
Formula
C25H22N4O4
Molar mass
442.48 g/mol
HS code
293319
Category
Screening compounds

What is Eltrombopag?

Plain description, key identifiers and synonyms

Eltrombopag is a hydrazine in which each nitrogen atom is substituted, one by a 3'-carboxy-2-hydroxy[1,1'-biphenyl]-3-yl group and the other by a 1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene group. A small molecule agonist of the c-mpl (TpoR) receptor (the physiological target of the hormone thrombopoietin), it has been developed as a medication for conditions that lead to thrombocytopenia (abnormally low platelet counts). It has a role as a xenobiotic and a thrombopoietin receptor agonist. It is a member of benzoic acids, a member of hydrazines and a member of pyrazoles.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-[3-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]diazenyl]-2-hydroxyphenyl]benzoic acid
CAS number
496775-61-2 CAS number cross-checkedOther or deprecated CAS: 1807882-48-9, 376591-99-0
Molecular formula
C25H22N4O4
UNII
4773K588MC, S56D65XJ9G
MDL number
MFCD20926253, MFCD21090400
InChIKey
SVOQIEJWJCQGDQ-UHFFFAOYSA-N
InChI
InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,28,30H,1-3H3,(H,32,33)
SMILES (canonical and isomeric)
CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C

Synonyms

  • (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
  • Eltrombopag-Isomer
  • SB 497115
  • (E)-Eltrombopag
  • (ZE)-Eltrombopag
  • 3'-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
  • 3'-{2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylidene]hydrazin-1-yl}-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
  • 3'-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy[1,1'-biphenyl]-3-carboxylic acid
  • 3-[3-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]diazenyl]-2-hydroxyphenyl]benzoic acid
  • (E)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
  • (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
  • 3'-[(2Z)- [1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
  • 3'-{2-[(4E)-1-(3,4-dimethylphenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylidene]hydrazin-1-yl}-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
  • Eltrombopag free base
  • 496775-61-2 (free base)
  • Eltrombopag, (E)-
  • Eltrombopag (Standard)
  • (E/Z)-Eltrombopag 13C
  • (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,
  • 3'-[[1-(3,4-DiMethylphenyl)-1,5-dihydro-3-Methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
  • Eltrombopag (SB-497115)
  • Eltrombopag - Bio-X trade mark
  • Eltrombopag (SB-497115-GR)
  • Eltrombopag (SB-497115-GR)?
  • 3'-(2-(2-(3,4-Dimethylphenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl)hydrazono)-2'-oxo-2',3'-dihydro-[1,1'-biphenyl]-3-carboxylic acid
Show all 30 synonyms
  • 3'-{2-[(4Z)-1-(3,4-dimethylphenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylidene]hydrazin-1-yl}-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
  • 3-[(5E)-5-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]hydrazono]-6-oxo-cyclohexa-1,3-dien-1-yl]benzoic acid
  • SB-497 115
  • SB-497115-GR, SB497115
  • Eltrombopag Impurity 46(Mixture Of Z/E-Isomers)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
442.48 g/molcalc.
Exact mass
442.1641 Dacalc.
LogP (octanol/water)
5.58calc.
Topological polar surface area
120 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
5calc.
Heavy atoms
33calc.
Rings
4calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.12calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1c(N=Nc2cccc(-c3ccccc3)c2)c[nH]n1-c1ccccc1

O=c1c(N=Nc2cccc(-c3ccccc3)c2)c[nH]n1-c1ccccc1

4 rings, 26 atoms.

15 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Eltrombopag suppliers

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Where suppliers are based

28 suppliers in 6 countries

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Eltrombopag price

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Uses and applications

What the substance is used for, by industry and function

Roles

  • agonist
  • anti-anaemic agent
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • hepatoprotective agent
  • pharmaceutical
  • protective agent
  • thrombopoietin receptor agonist
  • xenobiotic

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Eltrombopag is traded under.

HS 2933.19Indicative HS code

Compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the…

World exports in 2024
$3.44B
−22.6% vs 2023, imports $6.66B
2019 to 2024
Top exporters
  1. China21.6%
  2. Switzerland * partner reported20.5%
  3. Germany19.0%
Top importers
  1. Slovenia38.4%
  2. Portugal14.1%
  3. Brazil13.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Eltrombopag is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Eltrombopag, based on the data on this page

What is Eltrombopag?

Eltrombopag is a hydrazine in which each nitrogen atom is substituted, one by a 3'-carboxy-2-hydroxy[1,1'-biphenyl]-3-yl group and the other by a 1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene group.

What is the CAS number of Eltrombopag?

The CAS registry number of Eltrombopag is 496775-61-2. Other or deprecated CAS numbers: 1807882-48-9, 376591-99-0.

What is the molecular formula and weight of Eltrombopag?

The molecular formula of Eltrombopag is C25H22N4O4 and its molar mass is 442.48 g/mol.

What is Eltrombopag used for?

Known uses and roles of Eltrombopag include building blocks in research and laboratory, screening compounds in research and laboratory, agonist, anti-anaemic agent, antimicrobial agent and 7 more.

Is Eltrombopag hazardous?

No GHS hazard classification for Eltrombopag is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Eltrombopag?

Eltrombopag is usually classified under HS code 293319 (Compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Eltrombopag?

CompoundList lists 28 suppliers of Eltrombopag in China, United States, Germany, Canada and 2 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Eltrombopag in India?

1 supplier in India list Eltrombopag on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Eltrombopag?

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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