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Insecticides and acaricides

Endothion

Also known as Endocide, Endocid, Phosphopyron

CAS 2778-04-3Formula C9H13O6PSMolar mass 280.24 g/molEC 220-472-3
GHS signal word: Danger. Pictograms: Acute toxicity (severe)
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Endothion chemical structure, C9H13O6PS, CAS 2778-04-3
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
90 to 91
Solubility
In water, 1.5 × 10⁺⁶ mg/L
HS code
293299
Category
Insecticides and acaricides
Illustrative photo, a shrink wrapped pallet of kraft paper sacks in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Endothion?

Plain description, key identifiers and synonyms

Endothion is a member of 4-pyranones.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(dimethoxyphosphorylsulfanylmethyl)-5-methoxypyran-4-one
CAS number
2778-04-3 CAS number cross-checked
EC number
220-472-3
Molecular formula
C9H13O6PS
UNII
V047DQ6B7X
InChIKey
YCAGGFXSFQFVQL-UHFFFAOYSA-N
InChI
InChI=1S/C9H13O6PS/c1-12-9-5-15-7(4-8(9)10)6-17-16(11,13-2)14-3/h4-5H,6H2,1-3H3
SMILES (canonical and isomeric)
COC1=COC(=CC1=O)CSP(=O)(OC)OC

Synonyms

  • Endocide
  • Endocid
  • Phosphopyron
  • Phosphopyrone
  • Exothion
  • Phosphate 100
  • Niagara 5767
  • FMC 5767
  • Niagara-5767
  • ENT 24,653
  • 7175 RP
  • Phosphorothioic acid, O,O-dimethyl ester, S-ester with 2-(mercaptomethyl)-5-methoxy-4H-pyran-4-one
  • 5-Methoxy-2-(dimethoxyphosphinylthiomethyl)pyrone-4
  • AC-18,737
  • O,O-Dimethyl S-(5-methoxypyronyl-2-methyl) thiophosphate
  • S-(5-Methoxy-4-pyron-2-ylmethyl) dimethyl phosphorothiolate
  • S-5-Methoxy-4-oxopyran-2-ylmethyl dimethyl phosphorothioate
  • O,O-Dimethyl S-(5-methoxy-4-oxo-4H-pyran-2-yl)phosphorothioate
  • 5-Methoxy-2-(dimethoxyphosphinylthiomethyl) pyrone-4
  • Phosphorothioic acid, S-((5-methoxy-4-oxo-4H-pyran-2-yl)methyl) O,O-dimethyl ester
  • S-(5-Methoxy-4-pyron-2-ylmethyl) dimethyl phosphorothioate
  • O,O-Dimethyl-S-((5-methoxy-pyron-2-yl)-methyl)-thiolphosphat
  • S-5-Methoxy-4-pyron-2-ylmethyl O,O-dimethyl phosphorothioate
  • O,O-Dimethyl S-(5-methoxy-4-oxo-4H-pyran-2-yl) phosphorothioate
  • S-((5-Methoxy-4H-pyron-2-yl)-methyl)-O,O-dimethyl-monothiofosfaat
Show all 33 synonyms
  • S-((5-Metossi-4H-piron-2-il)-metil)-O,O-dimetil-monotiofosfato
  • Thiophosphate de O,O-dimethyle et de S-((5-methoxy-4-pyronyl)-methyle)
  • S-((5-Methoxy-4-oxo-4H-pyran-2-yl)methyl) O,O-dimethyl phosphorothioate
  • S-((5-Methoxy-4H-pyron-2-yl)-methyl)-O,O-dimethyl-monothiophosphat
  • O,O-Dimethyl phosphorothioate S-ester with 2-(mercaptomethyl)-5-methoxy-4H-pyran-4-one
  • 4-18-00-01160 (Beilstein Handbook Reference)
  • 2-Dimethoxyphosphinoylthiomethyl-5-methoxypyran-4-one
  • S-(5-Methoxy-4-pyron-2-ylmethyl) OO-dimethyl phosphorothioate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Melting point
90 to 91exp.
Solubility
In water, 1.5 × 10⁺⁶ mg/Lexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
280.24 g/molcalc.
Exact mass
280.017 Dacalc.
LogP (octanol/water)
2.28calc.
Topological polar surface area
74.97 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
6calc.
Heavy atoms
17calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.44calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1ccocc1

O=c1ccocc1

1 ring, 7 atoms, the 4H-Pyran-4-one ring system.

339 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
  • H311Toxic in contact with skin.
Precautionary statements (12)
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P316Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Endothion suppliers

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Endothion price

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Uses and applications

What the substance is used for, by industry and function

Acaricide/miticide, insecticide.

Systemic aphicide.

For the control of sap-feeding insects and mites of orchard, field, and market garden crops. ...

How it is made

Kojic acid is methylated and converted to 2-chloromethyl-5-methoxy-4-pyrone which is condensed with sodium O,O-dimethyl phosphorothioate

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 015-049-00-3

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Endothion is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Endothion is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Endothion, based on the data on this page

What is Endothion?

Endothion is a member of 4-pyranones.

What is the CAS number of Endothion?

The CAS registry number of Endothion is 2778-04-3.

What is the molecular formula and weight of Endothion?

The molecular formula of Endothion is C9H13O6PS and its molar mass is 280.24 g/mol.

What is Endothion used for?

Acaricide/miticide, insecticide. Systemic aphicide. For the control of sap-feeding insects and mites of orchard, field, and market garden crops. ...

Is Endothion hazardous?

Endothion carries the GHS signal word "Danger". Main hazards: toxic if swallowed, toxic in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Endothion?

Endothion is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Endothion?

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What is the price of Endothion?

Suppliers quote Endothion on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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