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Insecticides and acaricides

Endrin

Also known as Hexadrin, Mendrin, Nendrin

CAS 72-20-8Formula C12H8Cl6OMolar mass 380.91 g/molEC 200-775-7
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Hazardous to the environment Prohibited, not for trade
Why it is not for trade
Endrin chemical structure, C12H8Cl6O, CAS 72-20-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White, crystalline solid
Melting point
Ca. 200
Boiling point
245 °C
Density
Specific gravity 1.7 @ 20 °C.
Flash point
26.7 °C
HS code
291050
Category
Insecticides and acaricides
UN number
UN 2761

What is Endrin?

Plain description, key identifiers and synonyms

Endrin is a white crystalline, odorless solid dissolved in a liquid carrier. It is water emulsifiable. It is toxic by inhalation, skin absorption, and/or ingestion. When heated or burned it may emit toxic hydrogen chloride and phosgene. It is used as a pesticide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1R,2R,3R,6S,7S,8S,9S,11R)-3,4,5,6,13,13-hexachloro-10-oxapentacyclo[6.3.1.13,6.02,7.09,11]tridec-4-ene
CAS number
72-20-8 CAS number cross-checked
EC number
200-775-7
Molecular formula
C12H8Cl6O
UNII
OB9NVE7YCL
InChIKey
DFBKLUNHFCTMDC-GKRDHZSOSA-N
InChI
InChI=1S/C12H8Cl6O/c13-8-9(14)11(16)5-3-1-2(6-7(3)19-6)4(5)10(8,15)12(11,17)18/h2-7H,1H2/t2-,3+,4-,5+,6-,7+,10-,11+
Canonical SMILES
ClC1=C(Cl)C2(Cl)C3C4CC(C5OC45)C3C1(Cl)C2(Cl)Cl
Isomeric SMILES
C1[C@@H]2[C@@H]3[C@H]([C@H]1[C@H]4[C@@H]2O4)[C@@]5(C(=C([C@]3(C5(Cl)Cl)Cl)Cl)Cl)Cl

Synonyms

  • Hexadrin
  • Mendrin
  • Nendrin
  • Endricol
  • Oktanex
  • Endrex
  • Stardrin
  • Endrine
  • Compound 269
  • Stardrin 20
  • Rcra waste number P051
  • Experimental insecticide 269
  • Latka 269
  • OMS 197
  • EN 57
  • ENT 17,251
  • SD 3419
  • Hexachloroepoxyoctahydro-endo,endo-dimethanonaphthalene
  • 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-endo,endo-1,4:5,8-dimethanonaphthalene
  • (1R,4S,4aS,5S,6S,7R,8R,8aR)-1,2,3,4,10,10-Hexachloro-1,4,4a,5,6,7,8,8a-octahydro-6,7-epoxy-1,4:5,8-dimethanonaphthalene
  • 1,2,3,4,10,10-Hexachloro-1R,4S,4aS,5S,6,7R,8R,8aR-octahydro-6,7-epoxy-1,4:5,8-dimethanonaphthalene
  • 1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-, endo,endo-
  • 2,7:3,6-Dimethanonaphth(2,3-b)oxirene, 3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-, (1aalpha,2beta,2abeta,3alpha,6alpha,6abeta,7beta,7aalpha)-
  • (1Ar,2R,2ar,3R,6S,6as,7S,7as)-rel-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphth(2,3-b)oxirene
  • 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4-endo,endo-5,8-dimethanonaphthalene
Show all 35 synonyms
  • Isodrin epoxide
  • 2,7:3,6-DIMETHANONAPHTH(2,3-b)OXIRENE, 3,4,5,6,9,9-HEXACHLORO-1a,2,2a,3,6,6a,7,7a-OCTAHYDRO-, (1aR,2R,2aR,3R,6S,6aS,7S,7aS)-rel-
  • 3,4,5,6,13,13-hexachloro-10-oxapentacyclo(6.3.1.13,6.02,7.09,11)tridec-4-ene
  • Endrin isomer
  • (1R,2R,3R,6S,7S,8S,9S,11R)-3,4,5,6,13,13-hexachloro-10-oxapentacyclo[6.3.1.13,6.02,7.09,11]tridec-4-ene
  • Endrin 20 EC
  • Endrin and metabolites
  • (1R,2S,3S,6R,7R,8S,9R,11S)-3,4,5,6,13,13-Hexachloro-10-oxapentacyclo[6.3.1.13,6.02,7.09,11]tridec-4-ene
  • SD 3419 Illoxol
  • Hexachloroepoxyoctahydro-endo,endo-dimethanonapthalene

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White, crystalline solidexp.
Odour
Odorlessexp.
Melting point
Ca. 200exp.
Boiling point
245 °Cexp.
Density
Specific gravity 1.7 @ 20 °C.exp.
Flash point
26.7 °Cexp.
Solubility
In water, 0.25 mg/l @ 25 °Cexp.
Vapour pressure
3 × 10⁻⁶ mm Hg @ 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
380.91 g/molcalc.
Exact mass
377.8706 Dacalc.
LogP (octanol/water)
4.48calc.
Topological polar surface area
12.53 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
0calc.
Heavy atoms
19calc.
Rings
5calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.83calc.
Formal charge
0calc.
Stereocentres
8calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=CC2CC1C1C3CC(C4OC34)C21

C1=CC2CC1C1C3CC(C4OC34)C21

5 rings, 13 atoms.

9 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H300Fatal if swallowed.
  • H311Toxic in contact with skin.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (14)
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P316Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2761
Transport hazard class
6.1
Packing group
I

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Endrin suppliers

Trading restrictions apply to this substance

Persistent organic pollutant

Endrin is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: Stockholm Convention on Persistent Organic Pollutants, HS 2022 subheading 2910.50 (endrin)

Our policy on controlled substances

Endrin price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

The active ingredient is no longer contained in any registered pesticide products ... "cancelled.".

It is a non-systemic & persistent insecticide used mainly on field crops. It is non-phytotoxic @ insecticidal concn, but is suspected of (causing) damage to maize.

Insecticide used to control the army cutworm (Euxoa aoxiliaris), the pale western cutworm (Agrotis orthogonia), pine vole (Microtus pinetorium), meadow voles (Microtus species), and grasshoppers, but only when federal regulations are strictly followed.

Use classes: Pesticides, Insecticides.

Pharmacological actions

  • Insecticides

Roles

  • aetiopathogenetic role
  • avicide
  • environmental contaminant
  • neurotoxin
  • persistent organic pollutant
  • pesticide
  • poison
  • rodenticide
  • xenobiotic

Functional uses

  • Biocide

How it is made

Prepn from isodrin: H. Bluestone, US pat 2,676,132 (1943 to Shell), Marks, US pat 2,899,446 (1959 to Velsicol).

Prepn: endrin is produced by condensing hexachlorocyclopentadiene with vinyl chloride to produce heptachlorbicyclo-(2.2.1)-2-heptene. This is condensed with cyclopentadiene to form isodrin & that is oxidized to the 6,7-epoxide with peracetic or perbenzoic acid.

Regulatory status

Inventories, regulations and trade controls that list this substance

Persistent organic pollutant

Endrin is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: Stockholm Convention on Persistent Organic Pollutants, HS 2022 subheading 2910.50 (endrin)

Our policy on controlled substances

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 602-051-00-X

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: (1R,4S,5R,8S)-1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4:5,8-dimethanonaphthalene (endrin - ISO), Ref no: 196, Annex ref: II/196

Agriculture and environment

  • Stockholm Convention persistent organic pollutant

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Endrin is traded under.

HS 2910.50Exact HS code

Endrin (ISO)

World exports in 2024
$120K
−73.7% vs 2023, imports $361K
2019 to 2024
Top exporters
  1. United States69.1%
  2. India * partner reported19.4%
  3. Germany8.6%
Top importers
  1. Spain38.6%
  2. Czech Republic16.6%
  3. Poland15.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Endrin is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Endrin, based on the data on this page

What is Endrin?

Endrin is a white crystalline, odorless solid dissolved in a liquid carrier. It is water emulsifiable. It is toxic by inhalation, skin absorption, and/or ingestion. When heated or burned it may emit toxic hydrogen chloride and phosgene. It is used as a pesticide.

What is the CAS number of Endrin?

The CAS registry number of Endrin is 72-20-8.

What is the molecular formula and weight of Endrin?

The molecular formula of Endrin is C12H8Cl6O and its molar mass is 380.91 g/mol.

What is Endrin used for?

The active ingredient is no longer contained in any registered pesticide products ... "cancelled.". It is a non-systemic & persistent insecticide used mainly on field crops. It is non-phytotoxic @ insecticidal concn, but is suspected of (causing) damage to maize.

Is Endrin hazardous?

Endrin carries the GHS signal word "Danger". Main hazards: fatal if swallowed, toxic in contact with skin, very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Endrin?

Endrin is usually classified under HS code 291050 (Endrin (ISO)). This is indicative, confirm it with your customs broker before shipping.

Can I buy Endrin on CompoundList?

No. Endrin is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Endrin

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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