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Chlorinated and fluorinated solvents

Enflurane

Also known as Methylflurether, 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane, Efrane

CAS 13838-16-9Formula C3H2ClF5OMolar mass 184.49 g/molEC 237-553-4
GHS signal word: Warning. Pictograms: Harmful or irritant 60 suppliers listed
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Enflurane chemical structure, C3H2ClF5O, CAS 13838-16-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Clear, colorless liquid
Boiling point
56.5 °C
Density
1.5121 g/cm³ at 25 °C
Solubility
In water, 5.62 × 10⁺³ mg/L at 25 °C
HS code
290919
Category
Chlorinated and fluorinated solvents
Illustrative photo, clear liquid in sealed glass ampoules on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Enflurane?

Plain description, key identifiers and synonyms

Enflurane is an ether in which the oxygen atom is connected to 2-chloro-1,1,2-trifluoroethyl and difluoromethyl groups. It has a role as an anaesthetic. It is an ether, an organochlorine compound and an organofluorine compound. It is functionally related to a methoxyethane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
CAS number
13838-16-9 CAS number cross-checked
EC number
237-553-4
Molecular formula
C3H2ClF5O
UNII
91I69L5AY5
MDL number
MFCD00069095
InChIKey
JPGQOUSTVILISH-UHFFFAOYSA-N
InChI
InChI=1S/C3H2ClF5O/c4-1(5)3(8,9)10-2(6)7/h1-2H
SMILES (canonical and isomeric)
C(C(OC(F)F)(F)F)(F)Cl

Synonyms

  • Methylflurether
  • 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
  • Efrane
  • Ethrane
  • 2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether
  • Alyrane
  • Compound 347
  • Anesthetic 347
  • Anesthetic Compound No. 347
  • OHIO 347
  • Enflurano
  • Ethane, 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-
  • Enfluranum
  • Ether, 2-chloro-1,1,2-trifluoroethyl difluoromethyl
  • (2RS)-2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
  • 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-ethane
  • Ethrane (TN)
  • 1-(difluoromethoxy)-2-chloro-1,1,2-trifluoroethane
  • Enflurane [Anaesthetics, volatile]
  • (+-)-2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether
  • 4-Chloro-1H,4H-perfluoro(2-oxabutane)
  • Enflurane (JP18/USP/INN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Clear, colorless liquidexp.
Odour
Mild, sweet odorexp.
Boiling point
56.5 °Cexp.
Density
1.5121 g/cm³ at 25 °Cexp.
Solubility
In water, 5.62 × 10⁺³ mg/L at 25 °Cexp.
Vapour pressure
174.5 mm Hg at 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
184.49 g/molcalc.
Exact mass
183.9714 Dacalc.
LogP (octanol/water)
2.35calc.
Topological polar surface area
9.23 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
3calc.
Heavy atoms
10calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Enflurane suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 60 suppliers
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Where suppliers are based

60 suppliers in 11 countries

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Enflurane price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anesthetics, Inhalation

Roles

  • anaesthetic
  • pharmaceutical

Pharmacology

Enflurane is a General Anesthetic. The physiologic effect of enflurane is by means of General Anesthesia.

How it is made

Enflurane is prepared by dichlorination of the methyl group of 1-chloro-1,2,2-trifluoro-2- methoxyethane and replacement of these two chlorine atoms by fluorine.

Prepared by successive chlorination and fluorination of the hydrocarbon ether.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Enflurane is traded under.

HS 2909.19Indicative HS code

Acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives…

World exports in 2024
$10.2B
−8.7% vs 2023, imports $10.4B
2019 to 2024
Top exporters
  1. United States32.0%
  2. China22.3%
  3. Saudi Arabia12.9%
Top importers
  1. Singapore16.5%
  2. Mexico14.8%
  3. Japan14.8%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Enflurane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Enflurane, based on the data on this page

What is Enflurane?

Enflurane is an ether in which the oxygen atom is connected to 2-chloro-1,1,2-trifluoroethyl and difluoromethyl groups. It has a role as an anaesthetic. It is an ether, an organochlorine compound and an organofluorine compound. It is functionally related to a methoxyethane.

What is the CAS number of Enflurane?

The CAS registry number of Enflurane is 13838-16-9.

What is the molecular formula and weight of Enflurane?

The molecular formula of Enflurane is C3H2ClF5O and its molar mass is 184.49 g/mol.

What is Enflurane used for?

Known uses and roles of Enflurane include anaesthetic, pharmaceutical and anesthetics, inhalation.

Is Enflurane hazardous?

Enflurane carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Enflurane?

Enflurane is usually classified under HS code 290919 (Acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Enflurane?

CompoundList lists 60 suppliers of Enflurane in China, United States, United Kingdom, Germany and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Enflurane?

Suppliers quote Enflurane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Enflurane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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