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Central nervous system drugs

Isoflurane

Also known as 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether, Forane, 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane

CAS 26675-46-7Formula C3H2ClF5OMolar mass 184.49 g/molEC 247-897-7
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 102 suppliers listed Drug substance
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Isoflurane chemical structure, C3H2ClF5O, CAS 26675-46-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Clear, colorless liquid
Boiling point
48.5 °C
Density
1.45
Solubility
In water, 4.47 × 10⁺³ mg/L at 37 °C
HS code
290919
Category
Central nervous system drugs
Illustrative photo, clear liquid in a volumetric flask on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Isoflurane?

Plain description, key identifiers and synonyms

Isoflurane is an organofluorine compound. It has a role as an inhalation anaesthetic. It is functionally related to a methoxyethane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane
CAS number
26675-46-7 CAS number cross-checked
EC number
247-897-7
Molecular formula
C3H2ClF5O
UNII
CYS9AKD70P
MDL number
MFCD00066609
InChIKey
PIWKPBJCKXDKJR-UHFFFAOYSA-N
InChI
InChI=1S/C3H2ClF5O/c4-1(3(7,8)9)10-2(5)6/h1-2H
SMILES (canonical and isomeric)
C(C(F)(F)F)(OC(F)F)Cl

Synonyms

  • 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether
  • Forane
  • 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane
  • Forene
  • Aerrane
  • Isoflurano
  • Compound 469
  • IsoFlo
  • Isofluranum
  • Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-
  • Terrell
  • Compound-469
  • Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl
  • 2-chloro-2-difluoromethoxy-1,1,1-trifluoroethane
  • (2RS)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane
  • Fluriso
  • Isospire
  • IsoSol
  • Isoflurane, USP
  • Attane
  • R-E 235dal
  • C3H2ClF5O
  • AErrane (Veterinary)
  • Isoba, Isofor, Isoforine, Isorrane, R-E 235da1
  • 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-ethane
Show all 32 synonyms
  • Forane (TN)
  • Isoflurane [Anaesthetics, volatile]
  • 1-(difluoromethoxy)-1-chloro-2,2,2-trifluoroethane
  • Isoflurane CRS
  • Compd 469
  • Isoflurane, AldrichCPR
  • Difluoromethyl 1-chloro-2,2,2-trifluoroethyl ether (Isoflurane)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Clear, colorless liquidexp.
Odour
Slight odorexp.
Boiling point
48.5 °Cexp.
Density
1.45exp.
Solubility
In water, 4.47 × 10⁺³ mg/L at 37 °Cexp.
Vapour pressure
330 mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
184.49 g/molcalc.
Exact mass
183.9714 Dacalc.
LogP (octanol/water)
2.35calc.
Topological polar surface area
9.23 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
2calc.
Heavy atoms
10calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H336May cause drowsiness or dizziness.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (8)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P271Use only outdoors or in a well-ventilated area.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P319Get medical help if you feel unwell.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Isoflurane suppliers

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All 102 suppliers
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Where suppliers are based

102 suppliers in 19 countries

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Isoflurane price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Solvent and dispersant for fluorinated materials.

Veterinary medication:.

Use classes: Animal Drugs.

Industries and functions

Pharmacological actions

  • Anesthetics, Inhalation

Roles

  • anaesthetic
  • antimicrobial agent
  • antiviral agent
  • cardiovascular drug
  • general anaesthetic
  • inhalation anaesthetic
  • pharmaceutical

Pharmacology

Isoflurane is a General Anesthetic. The physiologic effect of isoflurane is by means of General Anesthesia.

How it is made

Trifluoroethanol is methylated with dimethyl sulfate to form the methyl ether, which is then chlorinated to the dichloromethyl ether ... This latter compound, on treatment with HF/SbCl5 forms the product.

Isoflurane is prepared by chlorination of 2,2,2-trifluoroethoxydifluoromethane, itself obtained by alkylation of trifluoroethanol with difluorochloromethane.

Preparation: Croix, Terrell, DE 1814962 (1969), Terrell, US 3535425 (both to Air Reduction)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Isoflurane is traded under.

HS 2909.19Indicative HS code

Acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives…

World exports in 2024
$10.2B
−8.7% vs 2023, imports $10.4B
2019 to 2024
Top exporters
  1. United States32.0%
  2. China22.3%
  3. Saudi Arabia12.9%
Top importers
  1. Singapore16.5%
  2. Mexico14.8%
  3. Japan14.8%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Isoflurane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Isoflurane, based on the data on this page

What is Isoflurane?

Isoflurane is an organofluorine compound. It has a role as an inhalation anaesthetic. It is functionally related to a methoxyethane.

What is the CAS number of Isoflurane?

The CAS registry number of Isoflurane is 26675-46-7.

What is the molecular formula and weight of Isoflurane?

The molecular formula of Isoflurane is C3H2ClF5O and its molar mass is 184.49 g/mol.

What is Isoflurane used for?

Solvent and dispersant for fluorinated materials. Veterinary medication:. Use classes: Animal Drugs.

Is Isoflurane hazardous?

Isoflurane carries the GHS signal word "Warning". Main hazards: may cause drowsiness or dizziness, may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Isoflurane?

Isoflurane is usually classified under HS code 290919 (Acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Isoflurane?

CompoundList lists 102 suppliers of Isoflurane in China, United States, United Kingdom, Germany and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Isoflurane in India?

5 suppliers in India list Isoflurane on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Isoflurane?

Suppliers quote Isoflurane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Isoflurane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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