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Antibiotics and anti-infectives

Ethionamide

Also known as 2-ethylpyridine-4-carbothioamide, Trecator, Ethioniamide

CAS 536-33-4Formula C8H10N2SMolar mass 166.25 g/molEC 208-628-9
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 93 suppliers listed Drug substance
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Ethionamide chemical structure, C8H10N2S, CAS 536-33-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Yellow crystals from ethanol
Melting point
164 to 166
Solubility
Very sparingly soluble in ether. Sparingly soluble in methanol, ethanol, propylene glyco…
HS code
293339
Category
Antibiotics and anti-infectives
Illustrative photo, yellow pigment powder in a glass jar on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Ethionamide?

Plain description, key identifiers and synonyms

Ethionamide is a thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide. It has a role as an antitubercular agent, an antilipemic drug, a leprostatic drug, a fatty acid synthesis inhibitor and a prodrug. It is a member of pyridines and a thiocarboxamide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-ethylpyridine-4-carbothioamide
CAS number
536-33-4 CAS number cross-checked
EC number
208-628-9
Molecular formula
C8H10N2S
UNII
OAY8ORS3CQ
MDL number
MFCD00057361
InChIKey
AEOCXXJPGCBFJA-UHFFFAOYSA-N
InChI
InChI=1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)
SMILES (canonical and isomeric)
CCC1=NC=CC(=C1)C(=S)N

Synonyms

  • 2-ethylpyridine-4-carbothioamide
  • Trecator
  • Ethioniamide
  • Amidazine
  • Ethinamide
  • Ethyonomide
  • Etionamid
  • Etioniamid
  • 2-Ethylthioisonicotinamide
  • Nizotin
  • Ethylisothiamide
  • Teberus
  • Trecator-SC
  • Amidazin
  • Bayer 5312
  • Iridocin
  • Iridozin
  • Sertinon
  • Thianide
  • Trescatyl
  • Etionid
  • 4-Pyridinecarbothioamide, 2-ethyl-
  • Etionizin
  • Etionizine
  • Ethimide
Show all 39 synonyms
  • Thianid
  • Trekator
  • Tuberoid
  • Aetina
  • Ethina
  • Tianid
  • Iridocin Bayer
  • Aethionamidum
  • Ethionamidum
  • Etionamida
  • Etionamide
  • 2-Ethyl-4-pyridinecarbothioamide
  • 2-Ethyl-4-thiocarbamoylpyridine
  • Tio-Mid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Yellow crystals from ethanolexp.
Odour
Faint to moderate sulfide odorexp.
Melting point
164 to 166exp.
Solubility
Very sparingly soluble in ether. Sparingly soluble in methanol, ethanol, propylene glycol. Soluble in hot acetone, dichloroethane. Freely soluble in pyridine.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
166.25 g/molcalc.
Exact mass
166.0565 Dacalc.
LogP (octanol/water)
1.28calc.
Topological polar surface area
38.91 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
2calc.
Heavy atoms
11calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccncc1

c1ccncc1

1 ring, 6 atoms, the Pyridine ring system.

118,162 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ethionamide suppliers

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All 93 suppliers
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Where suppliers are based

93 suppliers in 17 countries

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Ethionamide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Antibacterial (tuberculostatic).

Pharmacological actions

  • Antitubercular Agents
  • Fatty Acid Synthesis Inhibitors

Roles

  • antibacterial agent
  • antibacterial drug
  • antiinfective agent
  • antilipemic drug
  • antimicrobial agent
  • antimicrobial drug
  • antimycobacterial drug
  • antitubercular agent
  • enzyme inhibitor
  • fatty acid synthesis inhibitor
  • leprostatic drug
  • pathway inhibitor
  • pharmaceutical
  • pro-agent
  • prodrug

Pharmacology

Ethionamide is an Antimycobacterial.

How it is made

Prepared by addition of hydrogen sulfide to 2-ethylnicotinonitrile in the presence of triethanolamine

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Ethionamide (INN), Ref no: 319, Annex ref: II/319
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ethionamide is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ethionamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ethionamide, based on the data on this page

What is Ethionamide?

Ethionamide is a thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide.

What is the CAS number of Ethionamide?

The CAS registry number of Ethionamide is 536-33-4.

What is the molecular formula and weight of Ethionamide?

The molecular formula of Ethionamide is C8H10N2S and its molar mass is 166.25 g/mol.

What is Ethionamide used for?

Therapeutic category: Antibacterial (tuberculostatic).

Is Ethionamide hazardous?

Ethionamide carries the GHS signal word "Warning". Main hazards: harmful if swallowed, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ethionamide?

Ethionamide is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ethionamide?

CompoundList lists 93 suppliers of Ethionamide in United States, China, Germany, United Kingdom and 13 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Ethionamide in India?

3 suppliers in India list Ethionamide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Ethionamide?

Suppliers quote Ethionamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ethionamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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