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Heterocyclic building blocks

Prothionamide

Also known as Protionamide, 2-propylpyridine-4-carbothioamide, Trevintix

CAS 14222-60-7Formula C9H12N2SMolar mass 180.28 g/molEC 238-093-7
GHS signal word: Warning. Pictograms: Harmful or irritant 33 suppliers listed
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Prothionamide chemical structure, C9H12N2S, CAS 14222-60-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
14222-60-7
Formula
C9H12N2S
Molar mass
180.28 g/mol
EC number
238-093-7
HS code
293339
Category
Heterocyclic building blocks

What is Prothionamide?

Plain description, key identifiers and synonyms

Prothionamide is a member of pyridines.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-propylpyridine-4-carbothioamide
CAS number
14222-60-7 CAS number cross-checked
EC number
238-093-7
Molecular formula
C9H12N2S
UNII
76YOO33643
MDL number
MFCD00464119
InChIKey
VRDIULHPQTYCLN-UHFFFAOYSA-N
InChI
InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
SMILES (canonical and isomeric)
CCCC1=NC=CC(=C1)C(=S)N

Synonyms

  • Protionamide
  • 2-propylpyridine-4-carbothioamide
  • Trevintix
  • Protionamidum
  • Protionamida
  • RP 9778
  • Ektebin
  • Protionamid
  • 2-Propylthioisonicotinamide
  • Tuberex
  • 4-Pyridinecarbothioamide, 2-propyl-
  • Peteha
  • 2-Propyl-thioisonicotinamide
  • 2-Propylisonicotinylthioamide
  • Protionizina
  • Tebeform
  • 2-Propyl-4-pyridinecarbothioamide
  • 2-Propyl-4-thiocarbamoylpyridine
  • Isonicotinamide, 2-propylthio-
  • 9778 R.P.
  • 1321 TH
  • Protionamide (INN)
  • Prothionamidum
  • Protionamide 100 microg/mL in Acetonitrile
  • Protion
Show all 30 synonyms
  • Trevintix (TN)
  • TH 1321
  • Prothionamide (JP18)
  • Prothionamide (Standard)
  • Protionamide (Prothionamide)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
180.28 g/molcalc.
Exact mass
180.0721 Dacalc.
LogP (octanol/water)
1.67calc.
Topological polar surface area
38.91 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
12calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccncc1

c1ccncc1

1 ring, 6 atoms, the Pyridine ring system.

118,162 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Prothionamide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 33 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

33 suppliers in 9 countries

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Prothionamide price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antitubercular Agents

Roles

  • antibacterial agent
  • antibacterial drug
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • antimycobacterial drug
  • antitubercular agent
  • pharmaceutical

Pharmacology

Protionamide is a thioamide derivative with antitubercular activity. Protionamide forms a covalent adduct with bacterial nicotinamide adenine dinucleotide (NAD), PTH-NAD, which competitively inhibits 2-trans-enoyl-ACP reductase (inhA), an enzyme essential for mycolic acid synthesis. This results in increased cell wall permeability and decreased resistance against cell injury eventually leading to cell lysis. Mycolic acids, long-chain fatty acids, are essential mycobacterial cell wall components and play a key role in resistance to cell injury and mycobacterial virulence.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Prothionamide is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Prothionamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Prothionamide, based on the data on this page

What is Prothionamide?

Prothionamide is a member of pyridines.

What is the CAS number of Prothionamide?

The CAS registry number of Prothionamide is 14222-60-7.

What is the molecular formula and weight of Prothionamide?

The molecular formula of Prothionamide is C9H12N2S and its molar mass is 180.28 g/mol.

What is Prothionamide used for?

Known uses and roles of Prothionamide include building blocks in research and laboratory, screening compounds in research and laboratory, antibacterial agent, antibacterial drug, antiinfective agent and 6 more.

Is Prothionamide hazardous?

Prothionamide carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Prothionamide?

Prothionamide is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Prothionamide?

CompoundList lists 33 suppliers of Prothionamide in China, United States, Hong Kong, India and 5 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Prothionamide in India?

2 suppliers in India list Prothionamide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Prothionamide?

Suppliers quote Prothionamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Prothionamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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