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Skin conditioning agents and actives

Ethyl caffeate

Also known as ethyl trans-caffeate, Ethyl 3,4-dihydroxycinnamate, Caffeic acid ethyl ester

CAS 102-37-4Formula C11H12O4Molar mass 208.21 g/molEC 108-430-1
GHS signal word: Warning. Pictograms: Harmful or irritant 11 suppliers listed
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Ethyl caffeate chemical structure, C11H12O4, CAS 102-37-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
102-37-4
Formula
C11H12O4
Molar mass
208.21 g/mol
EC number
108-430-1
HS code
291829
Category
Skin conditioning agents and actives

What is Ethyl caffeate?

Plain description, key identifiers and synonyms

Ethyl trans-caffeate is an ethyl ester resulting from the formal condensation of the carboxy group of trans-caffeic acid with ethanol. It has a role as an antineoplastic agent and an anti-inflammatory agent. It is an ethyl ester and an alkyl caffeate ester. It is functionally related to a trans-caffeic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
ethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
CAS number
102-37-4 CAS number cross-checkedOther or deprecated CAS: 66648-50-8
EC numbers
108-430-1, 676-772-3
Molecular formula
C11H12O4
UNII
76GBB1JU5Y
MDL number
MFCD00045754
INCI name
ETHYL CAFFEATE
InChIKey
WDKYDMULARNCIS-GQCTYLIASA-N
InChI
InChI=1S/C11H12O4/c1-2-15-11(14)6-4-8-3-5-9(12)10(13)7-8/h3-7,12-13H,2H2,1H3/b6-4+
Canonical SMILES
CCOC(=O)C=Cc1ccc(O)c(O)c1
Isomeric SMILES
CCOC(=O)/C=C/C1=CC(=C(C=C1)O)O

Synonyms

  • ethyl trans-caffeate
  • Ethyl 3,4-dihydroxycinnamate
  • Caffeic acid ethyl ester
  • ethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
  • Ethyl 3-(3,4-dihydroxyphenyl)acrylate
  • (E)-Ethyl Dihydroxycinnamate
  • (E)-ethyl caffeate
  • 4gqq
  • Ethyl (2e)-3-(3,4-Dihydroxyphenyl)prop-2-Enoate
  • (E)-ethyl 3-(3,4-dihydroxyphenyl)acrylate
  • 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, ethyl ester
  • ethyl 3-(3,4-dihydroxyphenyl)prop-2-enoate
  • 3-(3,4-Dihydroxy-ph
  • Ethyl (E)-3-(3,4-dihydroxyphenyl)acrylate
  • 3,4-Dihydroxycinnamic acid ethyl ester
  • 3-(3,4-Dihydroxy-phenyl)-acrylic acid ethyl ester
  • Ethyl caffeate [M+H]+
  • (E)-ethyl 3,4-dihydroxycinnamate
  • ethyl trans-3,4-dihydroxycinnamate
  • Ethyl 3,4-dihydroxycinnamate, AldrichCPR
  • ethyl 3-(3,4-dihydroxyphenyl)-2-propenoate
  • ethyl (2E)-3-(3,4-dihydroxyphenyl)acrylate
  • Ethyl 1-(3'',4''-dihydroxyphenyl)propenate
  • (E)-Ethyl 3-(3,4-dihydroxyphenyl)prop-2-enoate
  • (E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid ethyl ester

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
208.21 g/molcalc.
Exact mass
208.0736 Dacalc.
LogP (octanol/water)
1.67calc.
Topological polar surface area
66.76 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
3calc.
Heavy atoms
15calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.18calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ethyl caffeate suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 11 suppliers
11 of 11 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

11 suppliers in 3 countries

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Ethyl caffeate price

Indicative price range per kg from live supplier offers

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Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name ETHYL CAFFEATE(skin conditioning)

Roles

  • anti-inflammatory agent
  • antineoplastic agent
  • metabolite
  • pharmaceutical

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ethyl caffeate is traded under.

HS 2918.29Indicative HS code

Carboxylic acids, (with phenol function but without other oxygen function), their anhydrides, halides…

World exports in 2024
$861M
+0.9% vs 2023, imports $892M
2019 to 2024
Top exporters
  1. China30.5%
  2. South Korea18.3%
  3. Switzerland * partner reported13.3%
Top importers
  1. United States14.7%
  2. Germany13.3%
  3. Japan10.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ethyl caffeate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ethyl caffeate, based on the data on this page

What is Ethyl caffeate?

Ethyl trans-caffeate is an ethyl ester resulting from the formal condensation of the carboxy group of trans-caffeic acid with ethanol. It has a role as an antineoplastic agent and an anti-inflammatory agent. It is an ethyl ester and an alkyl caffeate ester. It is functionally related to a trans-caffeic acid.

What is the CAS number of Ethyl caffeate?

The CAS registry number of Ethyl caffeate is 102-37-4. Other or deprecated CAS numbers: 66648-50-8.

What is the molecular formula and weight of Ethyl caffeate?

The molecular formula of Ethyl caffeate is C11H12O4 and its molar mass is 208.21 g/mol.

What is Ethyl caffeate used for?

Known uses and roles of Ethyl caffeate include skin conditioning agents in cosmetics and personal care, anti-inflammatory agent, antineoplastic agent, metabolite, pharmaceutical and 2 more.

Is Ethyl caffeate hazardous?

Ethyl caffeate carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ethyl caffeate?

Ethyl caffeate is usually classified under HS code 291829 (Carboxylic acids with phenol function but without other oxygen function, their…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ethyl caffeate?

CompoundList lists 11 suppliers of Ethyl caffeate in China, United Kingdom and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Ethyl caffeate?

Suppliers quote Ethyl caffeate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ethyl caffeate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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