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Steroids and sterols

Ethynodiol

Also known as Ethinodiol, Etynodiol, Aethynodiolum

CAS 1231-93-2Formula C20H28O2Molar mass 300.44 g/molEC 214-971-5
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Ethynodiol chemical structure, C20H28O2, CAS 1231-93-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1231-93-2
Formula
C20H28O2
Melting point
126 to 127 °C
Solubility
Solubility in double-distilled water, 0.26 mg/L /Ethynodiol diacetate/
HS code
293723
Category
Steroids and sterols

What is Ethynodiol?

Plain description, key identifiers and synonyms

Ethynodiol is a 17beta-hydroxy steroid, a 3beta-hydroxy steroid and a terminal acetylenic compound. It has a role as a progestin.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3S,8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
CAS number
1231-93-2 CAS number cross-checked
EC number
214-971-5
Molecular formula
C20H28O2
UNII
9E01C36A9S
InChIKey
JYILPERKVHXLNF-QMNUTNMBSA-N
InChI
InChI=1S/C20H28O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,12,14-18,21-22H,4-11H2,2H3/t14-,15-,16+,17+,18-,19-,20-/m0/s1
Canonical SMILES
C#CC1(O)CCC2C3CCC4=CC(O)CCC4C3CCC21C
Isomeric SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C[C@H](CC[C@H]34)O

Synonyms

  • Ethinodiol
  • Etynodiol
  • Aethynodiolum
  • Etinodiol
  • Etynodiolum
  • (3beta,17alpha)-19-Norpregn-4-en-20-yne-3,17-diol
  • (3beta,17beta)-17-ethynylestr-4-ene-3,17-diol
  • 17alpha-Ethynyl-19-norandrost-4-ene-3beta,17beta-diol
  • 17-alpha-Ethynyl-19-norandrost-4-ene-3-beta,17-beta-diol
  • Etynodol
  • 17 alpha-ethynyl-estra-4-ene-3 beta,17 beta-diol
  • 19-Norpregn-4-en-20-yne-3,17-diol, (3beta,17alpha)-
  • (3beta,17beta)-17-ethynylestr-4-ene-3,17-diol, 17alpha-ethynylestr-4-ene-3beta,17beta-diol
  • Etynodiol (INN)
  • 17alpha-ethynylestr-4-ene-3beta,17beta-diol
  • (3S,8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
  • Etinodiolo
  • (3-beta,17-alpha)-19-Norpregn-4-en-20-yne-3,17-diol
  • 3beta-hydroxynorethisterone
  • 17alpha-Ethynyl-estra-4-ene-3beta,17beta-diol
  • 19-Nor-17-alpha-pregn-4-en-20-yne-3-beta,17-diol
  • 19-Norpregn-4-en-20-yne-3,17-diol, (3-beta,17-alpha)-
  • 3beta-hydroxylynestrenol
  • 17alpha-19-Norpregn-4-en-20-yne-3beta,17-diol
  • (3beta,17.beta.)-17-ethynylestr-4-ene-3,17-diol
Show all 27 synonyms
  • 17alpha-ethynyl-4-oestrene-3beta,17beta-diol
  • Estr-4-ene-3,17-diol, 17-ethynyl-, (3beta,17.beta.)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Melting point
126 to 127 °Cexp.
Solubility
Solubility in double-distilled water, 0.26 mg/L /Ethynodiol diacetate/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
300.44 g/molcalc.
Exact mass
300.2089 Dacalc.
LogP (octanol/water)
3.28calc.
Topological polar surface area
40.46 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
0calc.
Heavy atoms
22calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.8calc.
Formal charge
0calc.
Stereocentres
7calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=C2CCC3C4CCCC4CCC3C2CCC1

C1=C2CCC3C4CCCC4CCC3C2CCC1

4 rings, 17 atoms.

99 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Ethynodiol suppliers

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Ethynodiol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • agonist
  • hormone
  • molecular messenger
  • progestin
  • progestogen
  • sex hormone

Pharmacology

Ethynodiol is a Progestin.

How it is made

Ethindrone is reduced to ethynodiol, which is acetylated with acetic anhydride in pyridine to produce ethynodiol diacetate. Ethynodiol diacetate can also be prepared from ethynodiol or from norethisterone by reducing the keto group to the carbinol and acetylating the 3- and 17-hydroxyls. It is not known which process is used for commercial production. (Ethynodiol diacetate)

Prepn: F.B. Colton, U.S. pat. 2843609 (1958 to Searle). Prepn of the 3-acetate, 17-acetate, and diacetate: P.D. Klimstra U.S. pat. 3176013 (1965 to Searle)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ethynodiol is traded under.

HS 2937.23Indicative HS code

Oestrogens and progestogens

World exports in 2024
$762M
−2.3% vs 2023, imports $693M
2019 to 2024
Top exporters
  1. China42.9%
  2. Italy18.4%
  3. Netherlands8.9%
Top importers
  1. India * partner reported12.1%
  2. United States11.0%
  3. Belgium8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ethynodiol is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ethynodiol, based on the data on this page

What is Ethynodiol?

Ethynodiol is a 17beta-hydroxy steroid, a 3beta-hydroxy steroid and a terminal acetylenic compound. It has a role as a progestin.

What is the CAS number of Ethynodiol?

The CAS registry number of Ethynodiol is 1231-93-2.

What is the molecular formula and weight of Ethynodiol?

The molecular formula of Ethynodiol is C20H28O2 and its molar mass is 300.44 g/mol.

What is Ethynodiol used for?

Known uses and roles of Ethynodiol include agonist, hormone, molecular messenger, progestin, progestogen and 1 more.

Is Ethynodiol hazardous?

No GHS hazard classification for Ethynodiol is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Ethynodiol?

Ethynodiol is usually classified under HS code 293723 (Oestrogens and progestogens). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ethynodiol?

Post a free request on CompoundList and suppliers of Ethynodiol will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Ethynodiol?

Suppliers quote Ethynodiol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ethynodiol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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