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Analgesics and anti-inflammatories

Etodolac

Also known as Etodolic acid, Lodine, Ultradol

CAS 41340-25-4Formula C17H21NO3Molar mass 287.36 g/molEC 629-689-1
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard 112 suppliers listed Drug substance
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Etodolac chemical structure, C17H21NO3, CAS 41340-25-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
41340-25-4
Formula
C17H21NO3
Molar mass
287.36 g/mol
EC number
629-689-1
HS code
293499
Category
Analgesics and anti-inflammatories

What is Etodolac?

Plain description, key identifiers and synonyms

Etodolac is a monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic and a cyclooxygenase 2 inhibitor. It is a monocarboxylic acid and an organic heterotricyclic compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(1,8-diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid
CAS number
41340-25-4 CAS number cross-checked
EC number
629-689-1
Molecular formula
C17H21NO3
UNII
2M36281008
MDL number
MFCD00133313
InChIKey
NNYBQONXHNTVIJ-UHFFFAOYSA-N
InChI
InChI=1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20)
SMILES (canonical and isomeric)
CCC1=C2C(=CC=C1)C3=C(N2)C(OCC3)(CC)CC(=O)O

Synonyms

  • Etodolic acid
  • Lodine
  • Ultradol
  • Lodine XL
  • Edolan
  • Ramodar
  • Etodolaco
  • Zedolac
  • Etodolacum
  • Flancox
  • Tedolan
  • AY 24236
  • AY-24,236
  • Eccoxolac
  • Napilac
  • Lodin xl
  • 1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid
  • (rs)-etodolic acid
  • Pyrano[3,4-b]indole-1-acetic acid, 1,8-diethyl-1,3,4,9-tetrahydro-
  • Lodine SR
  • 1,3,4,9-Tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic acid
  • 1,8-Diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
  • Pyrano(3,4-b)indole-1-acetic acid, 1,8-diethyl-1,3,4,9-tetrahydro-
  • (+-)-1,8-Diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
  • (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid
Show all 38 synonyms
  • 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-ylacetic acid
  • Ebretin
  • Etolyn
  • 1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indol-1-ylacetic acid
  • Etopan xl
  • EtoGesic Tablets
  • (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano(3,4-b)indol-1-yl)-acetic acid
  • Etodolac ER
  • AY 24,236
  • Etogesic Sterile Injectable Solution
  • 2-((1RS)-1,8-Diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indol-1-yl)acetic acid
  • rac-Etodolac
  • 2-(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
287.36 g/molcalc.
Exact mass
287.1521 Dacalc.
LogP (octanol/water)
3.38calc.
Topological polar surface area
62.32 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
4calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.47calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c3c([nH]c2c1)COCC3

c1ccc2c3c([nH]c2c1)COCC3

3 rings, 13 atoms.

67 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H319Causes serious eye irritation.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (13)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P337 + P317If eye irritation persists: Get medical help.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Etodolac suppliers

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All 112 suppliers
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Where suppliers are based

112 suppliers in 18 countries

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Etodolac price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals, Animal Drugs.

Pharmacological actions

  • Anti-Inflammatory Agents, Non-Steroidal
  • Cyclooxygenase 2 Inhibitors

Roles

  • analgesic
  • anti-inflammatory agent
  • anti-inflammatory drug
  • antineoplastic agent
  • antipyretic
  • antirheumatic drug
  • cyclooxygenase 2 inhibitor
  • enzyme inhibitor
  • non-narcotic analgesic
  • non-steroidal anti-inflammatory drug
  • pharmaceutical

Pharmacology

Etodolac is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of etodolac is as a Cyclooxygenase Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Etodolac is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Etodolac is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Etodolac, based on the data on this page

What is Etodolac?

Etodolac is a monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety.

What is the CAS number of Etodolac?

The CAS registry number of Etodolac is 41340-25-4.

What is the molecular formula and weight of Etodolac?

The molecular formula of Etodolac is C17H21NO3 and its molar mass is 287.36 g/mol.

What is Etodolac used for?

Use classes: Pharmaceuticals, Animal Drugs.

Is Etodolac hazardous?

Etodolac carries the GHS signal word "Danger". Main hazards: toxic if swallowed, causes serious eye irritation, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Etodolac?

Etodolac is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Etodolac?

CompoundList lists 112 suppliers of Etodolac in China, United States, India, United Kingdom and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Etodolac in India?

11 suppliers in India list Etodolac on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Etodolac?

Suppliers quote Etodolac on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Etodolac

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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