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Alkaloids

(-)-Galantamine

Also known as galanthamine, Galantamine, (-)-Galanthamine

CAS 357-70-0Formula C17H21NO3Molar mass 287.36 g/molEC 609-175-3
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard, Hazardous to the environment 84 suppliers listed Drug substance
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(-)-Galantamine chemical structure, C17H21NO3, CAS 357-70-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from benzene
Melting point
126 to 127
Solubility
Crystals from water, decomposition 256-257 °C. Sparingly sol in cold, more sol in hot wa…
HS code
293979
Category
Alkaloids
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is (-)-Galantamine?

Plain description, key identifiers and synonyms

Galanthamine is a benzazepine alkaloid isolated from certain species of daffodils. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor, a cholinergic drug, an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an antidote to curare poisoning and a plant metabolite. It is an organic heterotetracyclic compound, a benzazepine alkaloid, a benzazepine alkaloid fundamental parent and a tertiary amino compound. It is a conjugate base of a galanthamine(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol
CAS number
357-70-0 CAS number cross-checkedOther or deprecated CAS: 1008759-59-8, 23173-12-8
EC number
609-175-3
Molecular formula
C17H21NO3
UNII
0D3Q044KCA, 1T835Z585R
MDL number
MFCD00867189
InChIKey
ASUTZQLVASHGKV-JDFRZJQESA-N
InChI
InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
Canonical SMILES
COc1ccc2c3c1OC1CC(O)C=CC31CCN(C)C2
Isomeric SMILES
CN1CC[C@@]23C=C[C@@H](C[C@@H]2OC4=C(C=CC(=C34)C1)OC)O

Synonyms

  • galanthamine
  • Galantamine
  • (-)-Galanthamine
  • Lycoremine
  • Galantamina
  • Reminyl
  • Galanthaminum
  • Galantaminum
  • (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol
  • (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro(3a,3,2-ef)(2)benzazepin-6-ol
  • Reminyl XL
  • (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol
  • Galzemic xl
  • Lotprosin xl
  • Consion xl
  • Gatalin xl
  • Gazylan xl
  • Luventa xl
  • Zeebral xl
  • Acumor xl
  • Elmino xl
  • Galsya xl
  • (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo(8.6.1.01,12.06,17)heptadeca-6(17),7,9,15-tetraen-14-ol
  • 6H-Benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-
  • Lycoremin
Show all 36 synonyms
  • Jilkon
  • (+/-)-Galantamine
  • Bodamine
  • (+/-)-Galanthamine
  • Reminyl (TN)
  • Galantamine, (+/-)-
  • Galanthamine, (+/-)-
  • (4aS,6R,8aS)-3-Methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol
  • GNT
  • (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.0^{1,12}.0^{6,17}]heptadeca-6,8,10(17),15-tetraen-14-ol
  • 6H-Benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aR,6S,8aR)-rel-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from benzeneexp.
Melting point
126 to 127exp.
Solubility
Crystals from water, decomposition 256-257 °C. Sparingly sol in cold, more sol in hot water. Very sparingly sol in alcohol, acetone. /Hydrochloride/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
287.36 g/molcalc.
Exact mass
287.1521 Dacalc.
LogP (octanol/water)
1.85calc.
Topological polar surface area
41.93 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
1calc.
Heavy atoms
21calc.
Rings
4calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.53calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=CC23CCNCc4cccc(c42)OC3CC1

C1=CC23CCNCc4cccc(c42)OC3CC1

4 rings, 17 atoms.

41 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H301 + H331Toxic if swallowed. Toxic if inhaled.
  • H301Toxic if swallowed.
  • H315Causes skin irritation.
  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H331Toxic if inhaled.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (25)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

(-)-Galantamine suppliers

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All 84 suppliers
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Where suppliers are based

84 suppliers in 16 countries

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(-)-Galantamine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Cholinesterase inhibitor.

Drugs that affect the Nicotine system in the brain are currently the focus of very active research. Some clinicians use the currently available acetylcholinesterase inhibitors (Donepezil (Aricept), rivastigmine (Exelon) and galantamine (Reminyl) to treat ADHD in those cases where stimulants and antidepressants fail or worsen other concurrent conditions, such as bipolar disorder. The evidence in favor of this approach is still very limited.

Galantamine is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. / Included in US product labeling/.

Long been in use in Austria for treatment of indications such as facial neuralgia and residual polymyelitis paralysis.

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Cholinesterase Inhibitors
  • Nootropic Agents
  • Parasympathomimetics

Roles

  • anti-HIV agent
  • anti-obesity agent
  • antidepressant
  • antidote
  • antidote to curare poisoning
  • antimicrobial agent
  • antipsychotic agent
  • antiviral agent
  • anxiolytic drug
  • cardiovascular drug
  • central nervous system depressant
  • central nervous system drug
  • cholinergic drug
  • enzyme inhibitor
  • eukaryotic metabolite
  • metabolite
  • neurotransmitter agent
  • nootropic agent
  • pharmaceutical
  • plant metabolite
  • protective agent
  • psychotropic drug
  • tranquilizing drug
  • vasoconstrictor agent

Pharmacology

Galantamine is a Cholinesterase Inhibitor. The mechanism of action of galantamine is as a Cholinesterase Inhibitor.

How it is made

Originally isolated from the Caucasian snowdrop (Galanthus wrornowii VEL)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Galantamine (INN), Ref no: 193, Annex ref: II/193
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (-)-Galantamine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (-)-Galantamine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (-)-Galantamine, based on the data on this page

What is (-)-Galantamine?

Galanthamine is a benzazepine alkaloid isolated from certain species of daffodils. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor, a cholinergic drug, an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an antidote to curare poisoning and a plant metabolite.

What is the CAS number of (-)-Galantamine?

The CAS registry number of (-)-Galantamine is 357-70-0. Other or deprecated CAS numbers: 1008759-59-8, 23173-12-8.

What is the molecular formula and weight of (-)-Galantamine?

The molecular formula of (-)-Galantamine is C17H21NO3 and its molar mass is 287.36 g/mol.

What is (-)-Galantamine used for?

Therapeutic category: Cholinesterase inhibitor. Drugs that affect the Nicotine system in the brain are currently the focus of very active research.

Is (-)-Galantamine hazardous?

(-)-Galantamine carries the GHS signal word "Danger". Main hazards: toxic if swallowed. toxic if inhaled, toxic if swallowed, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of (-)-Galantamine?

(-)-Galantamine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (-)-Galantamine?

CompoundList lists 84 suppliers of (-)-Galantamine in United States, China, India, Germany and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy (-)-Galantamine in India?

9 suppliers in India list (-)-Galantamine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of (-)-Galantamine?

Suppliers quote (-)-Galantamine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle (-)-Galantamine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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