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Screening compounds

Evp4593

Also known as EVP 4593, QNZ quinazolinediamine, 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline

CAS 545380-34-5Formula C22H20N4OMolar mass 356.43 g/mol
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Evp4593 chemical structure, C22H20N4O, CAS 545380-34-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
545380-34-5
Formula
C22H20N4O
Molar mass
356.43 g/mol
HS code
293359
Category
Screening compounds

What is Evp4593?

Plain description, key identifiers and synonyms

EVP4593 is a member of the class of quinazolines that is quinazoline substituted by [2-(4-phenoxyphenyl)ethyl]amino and amino groups at positions 4 and 6, respectively. It is an inhibitor of NF-B signal transduction pathway and exhibits protective effects in oncology, cardiovascular disease and parasite invasion. It has a role as an antiparasitic agent, an antineoplastic agent, an EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor, an anti-inflammatory agent, an apoptosis inducer and a NF-kappaB inhibitor. It is a member of benzenes, an aromatic ether, a member of quinazolines, a primary amino compound and a secondary amino compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine
CAS number
545380-34-5 CAS number cross-checked
Molecular formula
C22H20N4O
MDL number
MFCD06411436
InChIKey
IBAKVEUZKHOWNG-UHFFFAOYSA-N
InChI
InChI=1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)
SMILES (canonical and isomeric)
C1=CC=C(C=C1)OC2=CC=C(C=C2)CCNC3=NC=NC4=C3C=C(C=C4)N

Synonyms

  • EVP 4593
  • QNZ quinazolinediamine
  • 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
  • QNZ
  • N4-(4-phenoxyphenethyl)quinazoline-4,6-diamine
  • QNZ (EVP4593)
  • 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine
  • NF-kB activation inhibitor
  • N4-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine
  • QNZ(EVP4593)
  • 4,6-Quinazolinediamine, N4-[2-(4-phenoxyphenyl)ethyl]-
  • N~4~-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine
  • N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine
  • 6-amino-4-(4-phenoxyphenylethylamino) quinazoline
  • 6-Amino-4-[2-(4-phenoxyphenyl)ethylamino]quinazoline
  • QNZ(EVP4593)?
  • 5?-Dihydro Testosterone Undecanoate
  • CAY 10470
  • Sdccgsbi-0086776.p003
  • EVP4593, >=98% (HPLC)
  • N(4)-(4-phenoxyphenethyl)quinazoline-4,6-diamine
  • N(4)-[2-(4-phenoxyphenyl)ethyl]-4,6-quinazolinediamine
  • N(4)-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
356.43 g/molcalc.
Exact mass
356.1637 Dacalc.
LogP (octanol/water)
4.66calc.
Topological polar surface area
73.06 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
6calc.
Heavy atoms
27calc.
Rings
4calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.09calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Oc2ccc(CCNc3ncnc4ccccc34)cc2)cc1

c1ccc(Oc2ccc(CCNc3ncnc4ccccc34)cc2)cc1

4 rings, 26 atoms.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Evp4593 suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 3 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

3 suppliers in 2 countries

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Evp4593 price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • NF-kappaB inhibitor
  • anti-inflammatory agent
  • antiinfective agent
  • antineoplastic agent
  • antiparasitic agent
  • apoptosis inducer
  • electron-transport chain inhibitor
  • enzyme inhibitor
  • pathway inhibitor
  • pharmaceutical
  • respiratory-chain inhibitor

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Evp4593 is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Evp4593 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Evp4593, based on the data on this page

What is Evp4593?

EVP4593 is a member of the class of quinazolines that is quinazoline substituted by [2-(4-phenoxyphenyl)ethyl]amino and amino groups at positions 4 and 6, respectively. It is an inhibitor of NF-B signal transduction pathway and exhibits protective effects in oncology, cardiovascular disease and parasite invasion.

What is the CAS number of Evp4593?

The CAS registry number of Evp4593 is 545380-34-5.

What is the molecular formula and weight of Evp4593?

The molecular formula of Evp4593 is C22H20N4O and its molar mass is 356.43 g/mol.

What is Evp4593 used for?

Known uses and roles of Evp4593 include building blocks in research and laboratory, screening compounds in research and laboratory, nf-kappab inhibitor, anti-inflammatory agent, antiinfective agent and 8 more.

Is Evp4593 hazardous?

No GHS hazard classification for Evp4593 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Evp4593?

Evp4593 is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Evp4593?

CompoundList lists 3 suppliers of Evp4593 in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Evp4593?

Suppliers quote Evp4593 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Evp4593

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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