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Impurities and reference standards

Fluocinolone

Also known as 6-alpha-Fluorotriamcinolone, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, 6-alpha,9-Difluoro-11-beta,16-alpha-17,21-tetrahydroxypregna-1,4-diene-3,20-dione

CAS 807-38-5Formula C21H26F2O6Molar mass 412.43 g/molEC 212-362-9
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Fluocinolone chemical structure, C21H26F2O6, CAS 807-38-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
807-38-5
Formula
C21H26F2O6
Molar mass
412.43 g/mol
EC number
212-362-9
HS code
293722
Category
Impurities and reference standards

What is Fluocinolone?

Plain description, key identifiers and synonyms

Fluocinolone is a fluorinated steroid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-difluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS number
807-38-5 CAS number cross-checked
EC number
212-362-9
Molecular formula
C21H26F2O6
UNII
CT1IX58L9S
MDL number
MFCD01699004
InChIKey
UUOUOERPONYGOS-CLCRDYEYSA-N
InChI
InChI=1S/C21H26F2O6/c1-18-4-3-10(25)5-13(18)14(22)6-12-11-7-15(26)21(29,17(28)9-24)19(11,2)8-16(27)20(12,18)23/h3-5,11-12,14-16,24,26-27,29H,6-9H2,1-2H3/t11-,12-,14-,15+,16-,18-,19-,20-,21-/m0/s1
Canonical SMILES
CC12C=CC(=O)C=C1C(F)CC1C3CC(O)C(O)(C(=O)CO)C3(C)CC(O)C12F
Isomeric SMILES
C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@H]([C@@]2(C(=O)CO)O)O)C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O

Synonyms

  • 6-alpha-Fluorotriamcinolone
  • 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • 6-alpha,9-Difluoro-11-beta,16-alpha-17,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione, 6-alpha,9-difluoro-11-beta,16-alpha,17,21-tetrahydroxy-
  • Fluocinolone Acetonide EP Impurity C
  • (6alpha,11beta,16alpha)-6,9-difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • 6-alpha,9-alpha-Difluoro-11-beta,16-alpha,17-alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • (6|A,11|A,16|A)-6,9-difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • 6alpha-fluorotriamcinolone
  • Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-
  • Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,16,17,21-tetrahydroxy-, (6alpha,11beta,16alpha)-
  • Fluocinolone acetonide impurity c
  • 16alpha-hydroxy-6alpha,9-difluoroprednisolone

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
412.43 g/molcalc.
Exact mass
412.1697 Dacalc.
LogP (octanol/water)
0.57calc.
Topological polar surface area
115.1 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
2calc.
Heavy atoms
29calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.71calc.
Formal charge
0calc.
Stereocentres
9calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

4 rings, 18 atoms.

956 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Fluocinolone suppliers

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All 5 suppliers
5 of 5 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

5 suppliers in 3 countries

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Fluocinolone price

Indicative price range per kg from live supplier offers

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Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacology

Fluocinolone is a synthetic glucocorticoid with anti-inflammatory and antipruritic activities. Fluocinolone binds the glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor induced by fluocinolone that interacts with and inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins.

Read more

In addition, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally, fluocinolone binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Fluocinolone is traded under.

HS 2937.22Indicative HS code

Halogenated derivatives of corticosteroidal hormones

World exports in 2024
$1.65B
−29.3% vs 2023, imports $1.67B
2019 to 2024
Top exporters
  1. United Kingdom69.1%
  2. Italy7.8%
  3. Singapore5.6%
Top importers
  1. United States64.5%
  2. Spain5.1%
  3. United Kingdom3.7%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Fluocinolone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Fluocinolone, based on the data on this page

What is Fluocinolone?

Fluocinolone is a fluorinated steroid.

What is the CAS number of Fluocinolone?

The CAS registry number of Fluocinolone is 807-38-5.

What is the molecular formula and weight of Fluocinolone?

The molecular formula of Fluocinolone is C21H26F2O6 and its molar mass is 412.43 g/mol.

Is Fluocinolone hazardous?

No GHS hazard classification for Fluocinolone is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Fluocinolone?

Fluocinolone is usually classified under HS code 293722 (Halogenated derivatives of corticosteroidal hormones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Fluocinolone?

CompoundList lists 5 suppliers of Fluocinolone in India, China and Poland. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Fluocinolone in India?

3 suppliers in India list Fluocinolone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Fluocinolone?

Suppliers quote Fluocinolone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Fluocinolone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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