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Hormones and steroids

Triamcinolone

Also known as Fluoxyprednisolone, Kenacort, Rodinolone

CAS 124-94-7Formula C21H27FO6Molar mass 394.44 g/molEC 204-718-7
GHS signal word: Warning. Pictograms: Serious health hazard 80 suppliers listed Drug substance
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Triamcinolone chemical structure, C21H27FO6, CAS 124-94-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
269 to 271
Solubility
FINE, WHITE OR SLIGHTLY OFF-WHITE CRYSTALS. SLIGHT, BITTER TASTE, SLIGHT ODOR, PRACTICAL…
HS code
293722
Category
Hormones and steroids
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Triamcinolone?

Plain description, key identifiers and synonyms

Triamcinolone is a C21-steroid hormone that is 1,4-pregnadiene-3,20-dione carrying four hydroxy substituents at positions 11beta, 16alpha, 17alpha and 21 as well as a fluoro substituent at position 9. Used in the form of its 16,17-acetonide to treat various skin infections. It has a role as an anti-inflammatory drug and an anti-allergic agent. It is a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone, a 16alpha-hydroxy steroid, a glucocorticoid, a 17alpha-hydroxy steroid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(4) steroid, a fluorinated steroid and a C21-steroid hormone. It derives from a hydride of a pregnane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS number
124-94-7 CAS number cross-checkedOther or deprecated CAS: 51855-44-8
EC number
204-718-7
Molecular formula
C21H27FO6
UNII
1ZK20VI6TY
MDL number
MFCD00010477
InChIKey
GFNANZIMVAIWHM-OBYCQNJPSA-N
InChI
InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1
Canonical SMILES
CC12C=CC(=O)C=C1CCC1C3CC(O)C(O)(C(=O)CO)C3(C)CC(O)C12F
Isomeric SMILES
C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@H]([C@@]2(C(=O)CO)O)O)CCC4=CC(=O)C=C[C@@]43C)F)O

Synonyms

  • Fluoxyprednisolone
  • Kenacort
  • Rodinolone
  • Volon
  • Triamcinolon
  • Delphicort
  • Ledercort
  • Tricortale
  • Celeste
  • Omcilon
  • Triamcinolona
  • Triamcinolonum
  • Fluoxiprednisolone
  • Tiamcinolonum
  • CL 19823
  • 9alpha-Fluoro-16alpha-hydroxyprednisolone
  • (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
  • 9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
  • 11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione
  • 9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy-
  • 9alpha-Fluoro-11beta,16alpha,17alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)-
  • (11beta,16alpha)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Show all 36 synonyms
  • (1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo(8.7.0.0^(2,7).0^(11,15))heptadeca-3,6-dien-5-one
  • (1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
  • (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta(a)phenanthren-3-one
  • (1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo(8.7.0.02,7.011,15)heptadeca-3,6-dien-5-one
  • Aristocort
  • Triamcet
  • Triam-Tablinen
  • Cinolone-T
  • SK-Triamcinolone
  • Triamcinlon
  • Triamcinalone

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Melting point
269 to 271exp.
Solubility
FINE, WHITE OR SLIGHTLY OFF-WHITE CRYSTALS. SLIGHT, BITTER TASTE, SLIGHT ODOR, PRACTICALLY INSOL IN WATER. SOL IN CHLOROFORM, SLIGHTLY SOL IN ETHER, SPARINGLY SOL IN ALC & METHANOL.exp.
Vapour pressure
7.20 × 10⁻¹⁵ mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
394.44 g/molcalc.
Exact mass
394.1792 Dacalc.
LogP (octanol/water)
0.62calc.
Topological polar surface area
115.1 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
2calc.
Heavy atoms
28calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.71calc.
Formal charge
0calc.
Stereocentres
8calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

4 rings, 18 atoms.

956 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H351Suspected of causing cancer.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Triamcinolone suppliers

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Where suppliers are based

80 suppliers in 19 countries

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Triamcinolone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Glucocorticoid used for systemic or local anti-inflammatory activity.

Treatment of inflammation and related disorders in dogs and cats, and management and treatment of acute arthritis and allergic and dermatologic disorders in dogs and cats. Treatment of inflammation and related disorders in horses. (Acetonide, Vetalog Parenteral Veterinary).

Topically: Use either ointment in cats for anti-inflammatory, antipruritic, antifungal, and antibacterial treatment of superficial bacterial infections, and for dermatologic disorders characterized by inflammation and dry or exudative dermatitis, particularly associated with bacterial or candidal (Candida albicans) infections. (Acetonide, Panolog Ointment).

The drug is recommended ... for topical treatment of summer eczema. (Acetonide, Vetalog Cream).

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Inflammatory Agents
  • Glucocorticoids

Roles

  • analgesic
  • anti-allergic agent
  • anti-inflammatory agent
  • anti-inflammatory drug
  • antineoplastic agent
  • antipsoriatic
  • dermatologic drug
  • nasal decongestant
  • ophthalmology drug
  • pharmaceutical

Pharmacology

Triamcinolone is a Corticosteroid. The mechanism of action of triamcinolone is as a Corticosteroid Hormone Receptor Agonist.

How it is made

Bernstein et al, Allen et al, US 2789118, US 3021347 (1957, 1962, both to American Cyanamid).

Triamcinolone is prepared commercially via a method developed by Bernstein and coworkers. By starting with cortisol 21-acetate, reaction with ethylene glycol gives the 3,20-bisethylene ketal. The 11b- and 17a-hydroxyl groups of this compound are then dehydrated with thionyl chloride in pyridine, followed by alkaline saponification of the 21-acetate group, acid deketalization of the cyclic acetal groups at positions 3 and 20, and reacetylation of the 21-hydroxyl group ...

Read more

Selective hydroxylation of the double bond at position 16 with osmium tetroxide in pyridine - benzene ... The 9,11-double bond of this compound is converted to a 9a-fluoro-11b-hydroxyl group ... Triamcinolone is obtained after alkaline saponification of the 21-acetate group and microbiological introduction of the D1 double bond with Corynebacterium simplex.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Triamcinolone is traded under.

HS 2937.22Indicative HS code

Halogenated derivatives of corticosteroidal hormones

World exports in 2024
$1.65B
−29.3% vs 2023, imports $1.67B
2019 to 2024
Top exporters
  1. United Kingdom69.1%
  2. Italy7.8%
  3. Singapore5.6%
Top importers
  1. United States64.5%
  2. Spain5.1%
  3. United Kingdom3.7%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Triamcinolone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Triamcinolone, based on the data on this page

What is Triamcinolone?

Triamcinolone is a C21-steroid hormone that is 1,4-pregnadiene-3,20-dione carrying four hydroxy substituents at positions 11beta, 16alpha, 17alpha and 21 as well as a fluoro substituent at position 9. Used in the form of its 16,17-acetonide to treat various skin infections.

What is the CAS number of Triamcinolone?

The CAS registry number of Triamcinolone is 124-94-7. Other or deprecated CAS numbers: 51855-44-8.

What is the molecular formula and weight of Triamcinolone?

The molecular formula of Triamcinolone is C21H27FO6 and its molar mass is 394.44 g/mol.

What is Triamcinolone used for?

Glucocorticoid used for systemic or local anti-inflammatory activity. Treatment of inflammation and related disorders in dogs and cats, and management and treatment of acute arthritis and allergic and dermatologic disorders in dogs and cats. Treatment of inflammation and related disorders in horses.

Is Triamcinolone hazardous?

Triamcinolone carries the GHS signal word "Warning". Main hazards: suspected of causing cancer, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Triamcinolone?

Triamcinolone is usually classified under HS code 293722 (Halogenated derivatives of corticosteroidal hormones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Triamcinolone?

CompoundList lists 80 suppliers of Triamcinolone in China, United States, India, United Kingdom and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Triamcinolone in India?

11 suppliers in India list Triamcinolone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Triamcinolone?

Suppliers quote Triamcinolone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Triamcinolone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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