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Central nervous system drugs

Fluphenazine

Also known as Triflumethazine, Fluorfenazine, Fluorophenazine

CAS 69-23-8Formula C22H26F3N3OSMolar mass 437.53 g/molEC 200-702-9
GHS signal word: Danger. Pictograms: Corrosive, Acute toxicity (severe), Harmful or irritant, Serious health hazard 46 suppliers listed Drug substance
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Fluphenazine chemical structure, C22H26F3N3OS, CAS 69-23-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Dark brown viscous oil
Melting point
235 to 237
Boiling point
250 to 252
Solubility
In water, 31.1 g/L (31.3 mg/L) at 37 °C
HS code
293430
Category
Central nervous system drugs
Illustrative photo, black 200 litre steel drums of dark liquid in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Fluphenazine?

Plain description, key identifiers and synonyms

Fluphenazine is a member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position. It has a role as an anticoronaviral agent, a phenothiazine antipsychotic drug and a dopaminergic antagonist. It is an organofluorine compound, a member of phenothiazines and a N-alkylpiperazine. It derives from a hydride of a 10H-phenothiazine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol
CAS number
69-23-8 CAS number cross-checkedOther or deprecated CAS: 146-56-5
EC number
200-702-9
Molecular formula
C22H26F3N3OS
UNII
S79426A41Z
MDL number
MFCD00242759
InChIKey
PLDUPXSUYLZYBN-UHFFFAOYSA-N
InChI
InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2
SMILES (canonical and isomeric)
C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO

Synonyms

  • Triflumethazine
  • Fluorfenazine
  • Fluorophenazine
  • Fluorphenazine
  • Siqualine
  • Sevinol
  • Flufenazina
  • Fluphenazinum
  • SQ 4918
  • Flufenazin
  • 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol
  • Moditen
  • 10-(3-(2-Hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine
  • 4-(3-(2-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol
  • 4-(3-(-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol
  • 1-(2-Hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine
  • 4-(3-(2-(Trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol
  • 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-
  • 10-(3'-(4''-(beta-Hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine
  • 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol
  • 2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine
  • 4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol
  • 1-Piperazineethanol, 4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-
  • 2-(4-(3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol
  • 4-[3-(2-Trifluoromethyl-10-phenothiazyl)-propyl]-1-piperazineethanol
Show all 38 synonyms
  • 2-(4-(3-(2-(Trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazinyl)ethanol
  • 2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-ol
  • 2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol
  • Siqualon
  • Elinol
  • Vespazine
  • Phthorphenazine
  • Ftorphenazine
  • Pacinol
  • Prolixin
  • Fluphenazine free base
  • flufenazine
  • 2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Dark brown viscous oilexp.
Melting point
235 to 237exp.
Boiling point
250 to 252exp.
Solubility
In water, 31.1 g/L (31.3 mg/L) at 37 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
437.53 g/molcalc.
Exact mass
437.1749 Dacalc.
LogP (octanol/water)
4.31calc.
Topological polar surface area
29.95 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
6calc.
Heavy atoms
30calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.46calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)Sc1ccccc1N2CCCN1CCNCC1

c1ccc2c(c1)Sc1ccccc1N2CCCN1CCNCC1

4 rings, 23 atoms, the 10-Piperazinylpropylphenothiazine ring system.

206 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H315Causes skin irritation.
  • H318Causes serious eye damage.
  • H330Fatal if inhaled.
  • H370Causes damage to organs.
Precautionary statements (22)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P308 + P316If exposed or concerned: Get emergency medical help immediately.
  • P316Get emergency medical help immediately.
  • P317Get medical help.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Fluphenazine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 46 suppliers
30 of 30 offers
  • SAG Chem
    India, Thane ManufacturerUnclaimed profile
    FluphenazineGrade, purity and minimum order on request
    Price on request
    View
  • Lavina Pharmaceuticals Pvt. Ltd
    India ManufacturerUnclaimed profile
    FluphenazineGrade, purity and minimum order on request
    Price on request
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  • Opulent Pharma
    India ManufacturerUnclaimed profile
    FluphenazineGrade, purity and minimum order on request
    Price on request
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  • WNS Feildpharma
    Pakistan ManufacturerUnclaimed profile
    FluphenazineGrade, purity and minimum order on request
    Price on request
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  • 001Chemical
    China, HangzhouUnclaimed profile
    FluphenazineGrade, purity and minimum order on request
    Price on request
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  • 3WAY Pharm Inc
    China, ShanghaiUnclaimed profile
    FluphenazineGrade, purity and minimum order on request
    Price on request
    View
  • A2B Chem LLC
    United States, San DiegoUnclaimed profile
    FluphenazineGrade, purity and minimum order on request
    Price on request
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  • Aa Blocks LLC
    United States, San DiegoUnclaimed profile
    FluphenazineGrade, purity and minimum order on request
    Price on request
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  • AbaChemScene, LLC
    United States, Monmouth JunctionUnclaimed profile
    FluphenazineGrade, purity and minimum order on request
    Price on request
    View
  • Achemtek
    United States, WoburnUnclaimed profile
    FluphenazineGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

46 suppliers in 14 countries

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Fluphenazine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

A phenothiazine used in the treatment of psychoses.

Tranquilizer.

Therapeutic category: Antipsychotic.

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Antipsychotic Agents
  • Dopamine Antagonists

Roles

  • antagonist
  • anticoronaviral agent
  • antimicrobial agent
  • antipsychotic agent
  • antiviral agent
  • central nervous system depressant
  • central nervous system drug
  • dopaminergic agent
  • dopaminergic antagonist
  • first generation antipsychotic
  • neurotransmitter agent
  • pharmaceutical
  • phenothiazine antipsychotic drug
  • psychotropic drug
  • tranquilizing drug

Pharmacology

Fluphenazine is a Phenothiazine.

How it is made

Fluphenazine may be prepared by condensing 2-(trifluoromethyl)-10-(3-chloropropyl)phenothiazine with 1-piperazineethanol in toluene with the aid of sodamide. ... The starting phenothiazine compound may be prepared by heating 3-(trifluoromethyl)diphenylamine with sulfur and condensing the resulting 2-(trifluoromethyl)phenothiazine with 1-bromo-3-chloropropane.

Fluphenazine may be prepared by condensing 2-(trifluoromethyl)-10-(3-chloropropyl)phenothiazine with 1-piperazineethanol in toluene with the aid of sodamide.

Read more

Reaction of the purified base with a double molar quantity of hydrogen chloride yields ... (the hydrochloride salt). ... The starting phenothiazine compound may be prepared by heating 3-(trifluoromethyl)diphenylamine with sulfur and condensing the resulting 2-(trifluoromethyl)phenothiazine with 1-bromo-3-chloropropane. (Fluphenazine hydrochloride)

Fluphenazine is esterified with decanoyl chloride in the presence of pyridine. (Fluphenazine decanoate)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Fluphenazine is traded under.

HS 2934.30Indicative HS code

Compounds containing in the structure a phenothiazine ring-system (whether or not…

World exports in 2024
$89.3M
−7.1% vs 2023, imports $97M
2019 to 2024
Top exporters
  1. Germany21.6%
  2. France * partner reported14.6%
  3. China13.0%
Top importers
  1. United States14.2%
  2. Brazil12.7%
  3. India * partner reported10.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Fluphenazine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Fluphenazine, based on the data on this page

What is Fluphenazine?

Fluphenazine is a member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position.

What is the CAS number of Fluphenazine?

The CAS registry number of Fluphenazine is 69-23-8. Other or deprecated CAS numbers: 146-56-5.

What is the molecular formula and weight of Fluphenazine?

The molecular formula of Fluphenazine is C22H26F3N3OS and its molar mass is 437.53 g/mol.

What is Fluphenazine used for?

A phenothiazine used in the treatment of psychoses. Tranquilizer. Therapeutic category: Antipsychotic. Use classes: Pharmaceuticals.

Is Fluphenazine hazardous?

Fluphenazine carries the GHS signal word "Danger". Main hazards: toxic if swallowed, causes skin irritation, causes serious eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Fluphenazine?

Fluphenazine is usually classified under HS code 293430 (Compounds containing in the structure a phenothiazine ring-system (whether or not…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Fluphenazine?

CompoundList lists 46 suppliers of Fluphenazine in United States, China, United Kingdom, India and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Fluphenazine in India?

3 suppliers in India list Fluphenazine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Fluphenazine?

Suppliers quote Fluphenazine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Fluphenazine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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