CompoundList
Sign in
Central nervous system drugs

Trifluoperazine

Also known as Trifluperazine, Trifluoroperazine, Trifluoperazin

CAS 117-89-5Formula C21H24F3N3SMolar mass 407.51 g/molEC 204-219-4
63 suppliers listed Drug substance
Get quotes Compare 63 suppliers
Trifluoperazine chemical structure, C21H24F3N3S, CAS 117-89-5
2D chemical structure

Key facts

What buyers check first

All properties
Melting point
242 to 243 °C
Boiling point
202 to 210 °C
Solubility
Freely sol in water /Dihydrochloride/
HS code
293430
Category
Central nervous system drugs

What is Trifluoperazine?

Plain description, key identifiers and synonyms

Trifluoperazine is a member of the class of phenothiazines that is phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position. It has a role as a calmodulin antagonist, a phenothiazine antipsychotic drug, a dopaminergic antagonist, an antiemetic, an EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor and an EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor. It is an organofluorine compound, a member of phenothiazines, a N-alkylpiperazine and a N-methylpiperazine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine
CAS number
117-89-5 CAS number cross-checkedOther or deprecated CAS: 81498-90-0
EC number
204-219-4
Molecular formula
C21H24F3N3S
UNII
214IZI85K3
MDL number
MFCD00242601
InChIKey
ZEWQUBUPAILYHI-UHFFFAOYSA-N
InChI
InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3
SMILES (canonical and isomeric)
CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F

Synonyms

  • Trifluperazine
  • Trifluoroperazine
  • Trifluoperazin
  • Triperazine
  • Trifluoperazina
  • Flurazine
  • Triflurin
  • Trifluoromethylperazine
  • Trifluoperazinum
  • 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine
  • Apo-Trifluoperazine
  • Triftazin
  • RP 7623
  • Eskazinyl
  • Modalina
  • Trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine
  • 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine
  • 10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-
  • Jatroneural
  • Triphthazine
  • 10-(3-(4-methylpiperazin-1-yl)propyl)-2-(trifluoromethyl)-10H-phenothiazine
  • 10-[3-(4-Methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine
  • 10-(gamma-(N'-Methylpiperazino)propyl)-2-trifluoromethylphenothiazine
  • Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-
  • 10H-Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-
Show all 38 synonyms
  • 10-[3-(4-Methyl-piperazin-1-yl)-propyl]-2-trifluoromethyl-10H-phenothiazine
  • 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine
  • Stelazine fte
  • 10-(3-(4-methylpiperazin-1-yl)propyl)-2-(trifluoromethyl)phenothiazine
  • Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-
  • ApoTrifluoperazine
  • 10-(3-(4-Methyl-piperazin-1-yl)-propyl)-2-trifluoromethyl-10H-phenothiazine
  • Apo Trifluoperazine
  • triphthazinum (for the hydrochloride)
  • Trifluroperizine
  • Fluoperazine
  • TFP
  • Calmazine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Melting point
242 to 243 °Cexp.
Boiling point
202 to 210 °Cexp.
Solubility
Freely sol in water /Dihydrochloride/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
407.51 g/molcalc.
Exact mass
407.1643 Dacalc.
LogP (octanol/water)
4.95calc.
Topological polar surface area
9.72 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
28calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.43calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)Sc1ccccc1N2CCCN1CCNCC1

c1ccc2c(c1)Sc1ccccc1N2CCCN1CCNCC1

4 rings, 23 atoms, the 10-Piperazinylpropylphenothiazine ring system.

206 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Trifluoperazine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 63 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

63 suppliers in 18 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Trifluoperazine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Antipsychotic.

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Antiemetics
  • Antipsychotic Agents
  • Dopamine Antagonists

Roles

  • antagonist
  • anti-anaemic agent
  • antiemetic
  • antipsychotic agent
  • calmodulin antagonist
  • central nervous system depressant
  • central nervous system drug
  • dopaminergic agent
  • dopaminergic antagonist
  • enzyme inhibitor
  • first generation antipsychotic
  • neurotransmitter agent
  • pharmaceutical
  • phenothiazine antipsychotic drug
  • psychotropic drug
  • tranquilizing drug

Pharmacology

Trifluoperazine is a Phenothiazine.

How it is made

Craig et al, J Org Chem 22, 709 (1957), British patents 813,861 & 829,246 (1959 & 1960 to SK & F).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Trifluoperazine is traded under.

HS 2934.30Indicative HS code

Compounds containing in the structure a phenothiazine ring-system (whether or not…

World exports in 2024
$89.3M
−7.1% vs 2023, imports $97M
2019 to 2024
Top exporters
  1. Germany21.6%
  2. France * partner reported14.6%
  3. China13.0%
Top importers
  1. United States14.2%
  2. Brazil12.7%
  3. India * partner reported10.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Trifluoperazine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Trifluoperazine, based on the data on this page

What is Trifluoperazine?

Trifluoperazine is a member of the class of phenothiazines that is phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.

What is the CAS number of Trifluoperazine?

The CAS registry number of Trifluoperazine is 117-89-5. Other or deprecated CAS numbers: 81498-90-0.

What is the molecular formula and weight of Trifluoperazine?

The molecular formula of Trifluoperazine is C21H24F3N3S and its molar mass is 407.51 g/mol.

What is Trifluoperazine used for?

Antipsychotic. Use classes: Pharmaceuticals.

Is Trifluoperazine hazardous?

No GHS hazard classification for Trifluoperazine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Trifluoperazine?

Trifluoperazine is usually classified under HS code 293430 (Compounds containing in the structure a phenothiazine ring-system (whether or not…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Trifluoperazine?

CompoundList lists 63 suppliers of Trifluoperazine in China, United States, United Kingdom, Bangladesh and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Trifluoperazine in India?

1 supplier in India list Trifluoperazine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Trifluoperazine?

Suppliers quote Trifluoperazine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Trifluoperazine

Get quotes for Trifluoperazine

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Trifluoperazine
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Trifluoperazine with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/trifluoperazine-117-89-5" title="Trifluoperazine structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Central nervous system drugs or HS code 293430

63 suppliers
Free quotes, contact stays private
Get quotes