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Central nervous system drugs

Perphenazine

Also known as Trilafon, Perphenazin, Perfenazine

CAS 58-39-9Formula C21H26ClN3OSMolar mass 403.98 g/molEC 200-381-5
GHS signal word: Danger. Pictograms: Corrosive, Acute toxicity (severe), Harmful or irritant, Serious health hazard 83 suppliers listed Drug substance
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Perphenazine chemical structure, C21H26ClN3OS, CAS 58-39-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
97 °C
Boiling point
214 to 218
Solubility
In water, 2.83 × 10⁻² g/L (28.3 mg/L) at 24 °C
HS code
293430
Category
Central nervous system drugs
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Perphenazine?

Plain description, key identifiers and synonyms

Perphenazine is a phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10. It has a role as a phenothiazine antipsychotic drug, a dopaminergic antagonist and an antiemetic. It is an organochlorine compound, a member of phenothiazines, a N-alkylpiperazine and a N-(2-hydroxyethyl)piperazine. It derives from a hydride of a 10H-phenothiazine.

Perphenazine is an antipsychotic medication.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol
CAS number
58-39-9 CAS number cross-checked
EC number
200-381-5
Molecular formula
C21H26ClN3OS
UNII
FTA7XXY4EZ
MDL number
MFCD00056798
InChIKey
RGCVKNLCSQQDEP-UHFFFAOYSA-N
InChI
InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
SMILES (canonical and isomeric)
C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO

Synonyms

  • Trilafon
  • Perphenazin
  • Perfenazine
  • Etaperazine
  • Chlorpiprazine
  • Etaperazin
  • Ethaperazine
  • Fentazin
  • Decentan
  • Perphenan
  • Perfenazina
  • Thilatazin
  • Trifaron
  • Chlorperphenazine
  • Triphenot
  • Emesinal
  • Trilifan
  • Perphenazinum
  • Sch 3940
  • 2-[4-[3-(2-Chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol
  • 2-(4-(3-(2-Chloro-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol
  • 4-[3-(2-Chlorophenothiazin-10-yl)propyl]-1-piperazineethanol
  • gamma-(4-(beta-Hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine
  • 4-(3-(2-Chlorophenothiazin-10-yl)propyl)-1-piperazineethanol
  • 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol
Show all 39 synonyms
  • 2-Chloro-10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)phenothiazine
  • 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethan-1-ol
  • 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol
  • 2-Chloro-10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazine
  • 1-Piperazineethanol, 4-(3-(2-chlorophenothiazin-10-yl)propyl)-
  • Piperazineethanol, 4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-
  • 2-(4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol
  • 1-Piperazineethanol, 4-[3-(2-chlorophenothiazin-10-yl)propyl]-
  • 2-(4-(3-(2-chlorophenothiazin-10-yl)propyl)piperazin-1-yl)ethanol
  • 4-(3-(2-Chloro-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol
  • Piperazineethanol, 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-
  • Trilafon-La
  • 2-(4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-1-piperazinyl)ethanol
  • 2-(4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-ol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Odour
Almost odorlessexp.
Taste
Bitter tasteexp.
Melting point
97 °Cexp.
Boiling point
214 to 218exp.
Solubility
In water, 2.83 × 10⁻² g/L (28.3 mg/L) at 24 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
403.98 g/molcalc.
Exact mass
403.1485 Dacalc.
LogP (octanol/water)
3.94calc.
Topological polar surface area
29.95 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
6calc.
Heavy atoms
27calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.43calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)Sc1ccccc1N2CCCN1CCNCC1

c1ccc2c(c1)Sc1ccccc1N2CCCN1CCNCC1

4 rings, 23 atoms, the 10-Piperazinylpropylphenothiazine ring system.

206 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H317May cause an allergic skin reaction.
  • H318Causes serious eye damage.
  • H330Fatal if inhaled.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (25)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Perphenazine suppliers

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All 83 suppliers
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Where suppliers are based

83 suppliers in 17 countries

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Perphenazine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Antipsychotic.

Therapeutic category (veterinary): Tranquilizer, pre-anesthetic agent.

Veterinary medication:.

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Antipsychotic Agents
  • Dopamine Antagonists

Roles

  • antagonist
  • antidepressant
  • antiemetic
  • antipsychotic agent
  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • dopaminergic agent
  • dopaminergic antagonist
  • first generation antipsychotic
  • neurotransmitter agent
  • pharmaceutical
  • phenothiazine antipsychotic drug
  • psychotropic drug
  • tranquilizing drug

Pharmacology

Perphenazine is a Phenothiazine.

How it is made

A toluene solution of 2-chloro-10-(3-chloropropyl)phenothiazine and 1-piperpazineethanol is refluxed with sodamide and the resulting perphenazine purified by means of vacuum distillation.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Perphenazine is traded under.

HS 2934.30Indicative HS code

Compounds containing in the structure a phenothiazine ring-system (whether or not…

World exports in 2024
$89.3M
−7.1% vs 2023, imports $97M
2019 to 2024
Top exporters
  1. Germany21.6%
  2. France * partner reported14.6%
  3. China13.0%
Top importers
  1. United States14.2%
  2. Brazil12.7%
  3. India * partner reported10.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Perphenazine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Perphenazine, based on the data on this page

What is Perphenazine?

Perphenazine is a phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10. It has a role as a phenothiazine antipsychotic drug, a dopaminergic antagonist and an antiemetic.

What is the CAS number of Perphenazine?

The CAS registry number of Perphenazine is 58-39-9.

What is the molecular formula and weight of Perphenazine?

The molecular formula of Perphenazine is C21H26ClN3OS and its molar mass is 403.98 g/mol.

What is Perphenazine used for?

Therapeutic category: Antipsychotic. Therapeutic category (veterinary): Tranquilizer, pre-anesthetic agent. Veterinary medication:. Use classes: Pharmaceuticals.

Is Perphenazine hazardous?

Perphenazine carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may cause an allergic skin reaction, causes serious eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Perphenazine?

Perphenazine is usually classified under HS code 293430 (Compounds containing in the structure a phenothiazine ring-system (whether or not…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Perphenazine?

CompoundList lists 83 suppliers of Perphenazine in United States, China, Germany, India and 13 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Perphenazine in India?

5 suppliers in India list Perphenazine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Perphenazine?

Suppliers quote Perphenazine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Perphenazine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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