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Screening compounds

Fovinaciclib

Also known as Fovinaciclibum, Futuoning (China), 7-Cyclopentyl-N,N-dimethyl-2-((5-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)pyridin-2-yl)amino)thieno[3,2-d]pyrimidine-6-carboxamide

CAS 2146171-49-3Formula C29H40N8OSMolar mass 548.76 g/mol
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Fovinaciclib chemical structure, C29H40N8OS, CAS 2146171-49-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2146171-49-3
Formula
C29H40N8OS
Molar mass
548.76 g/mol
HS code
293499
Category
Screening compounds

What is Fovinaciclib?

Plain description, key identifiers and synonyms

Fovinaciclib is an orally bioavailable inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon administration, fovinaciclib selectively inhibits CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma protein (Rb) early in the G1 phase, prevents CDK-mediated G1/S transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play key roles in the regulation of both cell cycle progression from the G1-phase into the S-phase and cell proliferation.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
7-cyclopentyl-N,N-dimethyl-2-[[5-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-2-pyridinyl]amino]thieno[3,2-d]pyrimidine-6-carboxamide
CAS number
2146171-49-3
Molecular formula
C29H40N8OS
UNII
LPW3H579X8
InChIKey
PGGPKYATZSPYKB-UHFFFAOYSA-N
InChI
InChI=1S/C29H40N8OS/c1-34(2)28(38)27-25(20-6-4-5-7-20)26-23(39-27)19-31-29(33-26)32-24-9-8-22(18-30-24)36-12-10-21(11-13-36)37-16-14-35(3)15-17-37/h8-9,18-21H,4-7,10-17H2,1-3H3,(H,30,31,32,33)
SMILES (canonical and isomeric)
CN1CCN(CC1)C2CCN(CC2)C3=CN=C(C=C3)NC4=NC=C5C(=N4)C(=C(S5)C(=O)N(C)C)C6CCCC6

Synonyms

  • Fovinaciclibum
  • Futuoning (China)
  • 7-Cyclopentyl-N,N-dimethyl-2-((5-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)pyridin-2-yl)amino)thieno[3,2-d]pyrimidine-6-carboxamide
  • 7-cyclopentyl-N,N-dimethyl-2-[[5-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]pyridin-2-yl]amino]thieno[3,2-d]pyrimidine-6-carboxamide
  • FCN-437c
  • Example 5
  • 7-Cyclopentyl-N,N-dimethyl-2-((5-(4-(4-methylpiperazin-1- yl)piperidin-1-yl) pyridin-2-yl)amino)thieno(3,2-d)pyrimidine- 6-carboxamide
  • 7-Cyclopentyl-N,N-dimethyl-2-[[5-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]-2-pyridinyl]amino]thieno[3,2-d]pyrimidine-6-carboxamide
  • 7-cyclopentyl-N,N-dimethyl-2-[[5-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-2-pyridinyl]amino]thieno[3,2-d]pyrimidine-6-carboxamide
  • Thieno(3,2-d)pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-((5-(4-(4-methyl-1-piperazinyl)-1-piperidinyl)-2-pyridinyl)amino)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
548.76 g/molcalc.
Exact mass
548.3046 Dacalc.
LogP (octanol/water)
4.41calc.
Topological polar surface area
80.73 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
9calc.
Rotatable bonds
6calc.
Heavy atoms
39calc.
Rings
6calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.59calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc(Nc2ncc3scc(C4CCCC4)c3n2)ncc1N1CCC(N2CCNCC2)CC1

c1cc(Nc2ncc3scc(C4CCCC4)c3n2)ncc1N1CCC(N2CCNCC2)CC1

6 rings, 33 atoms.

No other chemical in our database has this scaffold.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Fovinaciclib suppliers

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Fovinaciclib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Fovinaciclib is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Fovinaciclib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Fovinaciclib, based on the data on this page

What is Fovinaciclib?

Fovinaciclib is an orally bioavailable inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity.

What is the CAS number of Fovinaciclib?

The CAS registry number of Fovinaciclib is 2146171-49-3.

What is the molecular formula and weight of Fovinaciclib?

The molecular formula of Fovinaciclib is C29H40N8OS and its molar mass is 548.76 g/mol.

What is Fovinaciclib used for?

Known uses and roles of Fovinaciclib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Fovinaciclib hazardous?

No GHS hazard classification for Fovinaciclib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Fovinaciclib?

Fovinaciclib is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Fovinaciclib?

Post a free request on CompoundList and suppliers of Fovinaciclib will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Fovinaciclib?

Suppliers quote Fovinaciclib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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