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Vitamins and nutraceutical actives

(+)-gamma-Tocopherol

Also known as gamma-Tocopherol, 7,8-Dimethyltocol, o-Xylotocopherol

CAS 54-28-4Formula C28H48O2Molar mass 416.69 g/molEC 200-201-5
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(+)-gamma-Tocopherol chemical structure, C28H48O2, CAS 54-28-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
54-28-4
Formula
C28H48O2
Molar mass
416.69 g/mol
Physical form
Liquid
HS code
293628
Category
Vitamins and nutraceutical actives
Illustrative photo, 200 litre steel drums of liquid in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is (+)-gamma-Tocopherol?

Plain description, key identifiers and synonyms

Gamma-tocopherol is a tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 7 and 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils. It has a role as a plant metabolite, a food antioxidant and an algal metabolite. It is a tocopherol and a vitamin E.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2R)-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
CAS number
54-28-4 CAS number cross-checkedOther or deprecated CAS: 7616-22-0
EC numbers
200-201-5, 231-523-4
Molecular formula
C28H48O2
UNII
8EF1Z1238F
MDL number
MFCD00066529
INCI name
TOCOPHEROL
InChIKey
QUEDXNHFTDJVIY-DQCZWYHMSA-N
InChI
InChI=1S/C28H48O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h19-22,29H,8-18H2,1-7H3/t21-,22-,28-/m1/s1
Canonical SMILES
Cc1c(O)cc2c(c1C)OC(C)(CCCC(C)CCCC(C)CCCC(C)C)CC2
Isomeric SMILES
CC1=C(C=C2CC[C@@](OC2=C1C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)O

Synonyms

  • gamma-Tocopherol
  • 7,8-Dimethyltocol
  • o-Xylotocopherol
  • Gamma tocopherol
  • (2R)-3,4-dihydro-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
  • (2R)-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-ol
  • 3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol
  • RRR-gamma-Tocopherol
  • (R,R,R)-gamma-Tocopherol
  • (2R)-3,4-Dihydro-2,7,8-trimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol
  • 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, (2R)-
  • 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)-
  • (2R)-2,7,8-trimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-ol
  • 2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol
  • D-gamma-Tocopherol
  • (R)-2,7,8-trimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-ol
  • (2R)-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
  • (2R)-2,7,8-Trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-ol
  • (+)-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol
  • 2,7,8-Trimethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol
  • D-?-Tocopherol
  • gamma-Tocopherol, d-
  • D-gamma-Tocopherol, <BR>RRR-|A-Tocopherol EP Impurity C
  • 7,8-Dimethyltocolo-xylotocopherol
  • (2r)-2,7,8-trimethyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]chroman-6-ol
Show all 33 synonyms
  • Tocopherol
  • tocopherol gamma
  • Vitamin E gamma
  • ??-Tocopherol
  • 7,8-Dimethyltocol, (R)-2,7,8-trimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-ol
  • A-Tocopherol (Standard)
  • 4(3H)-Quinazolinone, 2-
  • D--Tocopherol, (+)--Tocopherol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Liquidexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
416.69 g/molcalc.
Exact mass
416.3654 Dacalc.
LogP (octanol/water)
8.53calc.
Topological polar surface area
29.46 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
12calc.
Heavy atoms
30calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.79calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CCCO2

c1ccc2c(c1)CCCO2

2 rings, 10 atoms, the Chroman ring system.

4,102 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

(+)-gamma-Tocopherol suppliers

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Where suppliers are based

38 suppliers in 9 countries

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(+)-gamma-Tocopherol price

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Uses and applications

What the substance is used for, by industry and function

Use classes: Food additives, Preservatives and Antioxidants, Safer Chemical Classes.

Cosmetic ingredient, INCI name TOCOPHEROL(antioxidant, fragrance, skin conditioning - miscellaneous, skin conditioning - occlusive)

Pharmacological actions

  • Antioxidants
  • Vitamins

Roles

  • additive
  • algal metabolite
  • anti-asthmatic agent
  • anti-inflammatory agent
  • antioxidant
  • eukaryotic metabolite
  • food additive
  • food antioxidant
  • food component
  • food preservative
  • metabolite
  • physiological role
  • plant metabolite

Functional uses

  • Fragrance

Cosmetic functions

  • Antioxidant
  • Fragrance
  • Skin conditioning - miscellaneous
  • Skin conditioning - occlusive

Pharmacology

Gamma-Tocopherol is the orally bioavailable gamma form of the naturally-occurring fat-soluble vitamin E, found in certain nuts and seeds, with potential antioxidant activity. Although the exact mechanism of action of this tocopherol has yet to be fully identified, gamma-tocopherol appears to have the ability to scavenge free radicals, thereby protecting against oxidative damage.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Food additive

United States

  • Safer Choice ingredient list (USA)
  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (+)-gamma-Tocopherol is traded under.

HS 2936.28Indicative HS code

Vitamin E and its derivatives

World exports in 2024
$2.27B
+26.5% vs 2023, imports $2.27B
2019 to 2024
Top exporters
  1. China54.5%
  2. Switzerland * partner reported15.5%
  3. Netherlands11.1%
Top importers
  1. United States21.2%
  2. Netherlands10.2%
  3. Germany10.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (+)-gamma-Tocopherol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (+)-gamma-Tocopherol, based on the data on this page

What is (+)-gamma-Tocopherol?

Gamma-tocopherol is a tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 7 and 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils. It has a role as a plant metabolite, a food antioxidant and an algal metabolite. It is a tocopherol and a vitamin E.

What is the CAS number of (+)-gamma-Tocopherol?

The CAS registry number of (+)-gamma-Tocopherol is 54-28-4. Other or deprecated CAS numbers: 7616-22-0.

What is the molecular formula and weight of (+)-gamma-Tocopherol?

The molecular formula of (+)-gamma-Tocopherol is C28H48O2 and its molar mass is 416.69 g/mol.

What is (+)-gamma-Tocopherol used for?

Use classes: Food additives, Preservatives and Antioxidants, Safer Chemical Classes.

Is (+)-gamma-Tocopherol hazardous?

No GHS hazard classification for (+)-gamma-Tocopherol is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of (+)-gamma-Tocopherol?

(+)-gamma-Tocopherol is usually classified under HS code 293628 (Vitamin E and its derivatives). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (+)-gamma-Tocopherol?

CompoundList lists 38 suppliers of (+)-gamma-Tocopherol in China, United States, Germany, Canada and 5 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of (+)-gamma-Tocopherol?

Suppliers quote (+)-gamma-Tocopherol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle (+)-gamma-Tocopherol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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