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Insecticides and acaricides

Hexamethylphosphoramide

Also known as HMPA, Hexamethylphosphoric triamide, Hexametapol

CAS 680-31-9Formula C6H18N3OPMolar mass 179.20 g/molEC 211-653-8
GHS signal word: Danger. Pictograms: Serious health hazard 33 suppliers listed
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Hexamethylphosphoramide chemical structure, C6H18N3OP, CAS 680-31-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless, mobile liquid
Melting point
5 to 7
Boiling point
233 °C
Density
Relative density (water = 1): 1.03
Flash point
105 °C
HS code
294200
Category
Insecticides and acaricides
UN number
UN 2810
Illustrative photo, an amber glass solvent bottle with clear liquid on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Hexamethylphosphoramide?

Plain description, key identifiers and synonyms

Hexamethylphosphoric triamide is a phosphoramide. It has a role as a mutagen and an insect sterilant.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[bis(dimethylamino)phosphoryl]-N-methylmethanamine
CAS number
680-31-9 CAS number cross-checkedOther or deprecated CAS: 630-31-9
EC number
211-653-8
Molecular formula
C6H18N3OP
UNII
M42TU5843Z
MDL number
MFCD00008303
InChIKey
GNOIPBMMFNIUFM-UHFFFAOYSA-N
InChI
InChI=1S/C6H18N3OP/c1-7(2)11(10,8(3)4)9(5)6/h1-6H3
SMILES (canonical and isomeric)
CN(C)P(=O)(N(C)C)N(C)C

Synonyms

  • HMPA
  • Hexamethylphosphoric triamide
  • Hexametapol
  • Hempa
  • HMPTA
  • Hexamethylphosphoric acid triamide
  • Phosphoric hexamethyltriamide
  • Hexamethylphosphorotriamide
  • Eastman Inhibitor HPT
  • Phosphoric triamide, hexamethyl-
  • Hexamethylphosphotriamide
  • Tris(dimethylamino)phosphine oxide
  • Hexamethylorthophosphoric triamide
  • Phosphoric acid hexamethyltriamide
  • Phosphoric tris(dimethylamide)
  • Phosphoryl hexamethyltriamide
  • Hexamethyl phosphoramide
  • N,N,N',N',N'',N''-hexamethylphosphoric triamide
  • Hexamethylfosforamid
  • Tris(dimethylamino)phosphorus oxide
  • ENT 50882
  • Hexamethylphosphamide
  • ENT 50,882
  • hexamethylphosphoramide triamide
  • Tris-(dimethylamid) kyseliny fosforecne
Show all 38 synonyms
  • N,N,N,N,N,N-Hexamethylphosphoric triamide
  • Triamide, Hexamethylphosphoric
  • HMPT
  • hexamethyltriamidophosphate
  • N-[bis(dimethylamino)phosphoryl]-N-methylmethanamine
  • [bis(dimethylamino)phosphoryl]dimethylamine
  • Hexamethylphosphoramid
  • N-Bis(dimethylamino)phosphoryl-N-methyl-methanamine
  • Hexamethylphosphorsaeuretriamid
  • Hexamethylphosphorictriamide
  • HPT
  • N,N,N',N',N'',N''-Hexamethylphosphorotriamide
  • phosphoric triamide, N,N,N',N',N'',N''-hexamethyl-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless, mobile liquidexp.
Odour
AROMATIC ODORexp.
Melting point
5 to 7exp.
Boiling point
233 °Cexp.
Density
Relative density (water = 1): 1.03exp.
Flash point
105 °Cexp.
Solubility
MISCIBLE WITH WATER & WITH MOST ORG LIQ, IMMISCIBLE WITH HIGH-BOILING SATURATED HYDROCARBONSexp.
Vapour pressure
0.03 MM HG @ ROOM TEMPexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
179.20 g/molcalc.
Exact mass
179.1187 Dacalc.
LogP (octanol/water)
0.78calc.
Topological polar surface area
26.79 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
3calc.
Heavy atoms
11calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H340May cause genetic defects.
  • H350May cause cancer.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2810

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Hexamethylphosphoramide suppliers

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All 33 suppliers
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Where suppliers are based

33 suppliers in 7 countries

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Hexamethylphosphoramide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Processing solvent for aromatic polyamide fiber.

De-icing additive for jet fuels, (experimental) chemosterilant for a number of insect pests, as a chemical mutagen.

As a solvent for polymers, as a selective solvent for gases, as a polymerization catalyst, as a stabilizer against thermal degradation in polystyrene, as an additive to polyvinyl & polyolefin resins to protect against degradation by UV light, & as a solvent in org & organometallic reactions in research lab.

Hexamethylphosphoramide is no longer used in large quantities in the United States. Hexamethylphosphoramide was used in the past as a selective solvent for gases, a polymerization catalyst, a stabilizer against thermal degradation in polystyrene, and an additive to polyvinyl resins.

Pharmacological actions

  • Chemosterilants

Roles

  • aetiopathogenetic role
  • chemosterilant
  • genotoxin
  • insect sterilant
  • insecticide
  • mutagen
  • pesticide

Pharmacology

Hexamethylphosphoramide is a clear, colorless liquid with an aromatic odor that emits toxic fumes of phosphorous oxides and nitrogen oxides when heated to decomposition. Hexamethylphosphoramide is used as a stabilizer against thermal degradation in polystyrene and is used as a solvent in research laboratories. Exposure to this substance irritates the eyes, skin and respiratory-tract. Hexamethylphosphoramide is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)

How it is made

Reaction of an excess of dimethylamine with phosphorus oxychloride

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 015-106-00-2

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Hexamethylphosphoric-triamide, Ref no: 748, Annex ref: II/748

United States

  • TSCA inventory (USA)
    Status: Active in US commerce, Regulatory flags: Significant new use rule

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Hexamethylphosphoramide is traded under.

HS 2942.00Indicative HS code

Organic compounds not elsewhere classified in chapter 29

World exports in 2024
$589M
−43.5% vs 2023, imports $614M
2019 to 2024
Top exporters
  1. India * partner reported20.7%
  2. United States18.6%
  3. Italy10.4%
Top importers
  1. United States15.1%
  2. Italy6.7%
  3. Japan5.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Hexamethylphosphoramide is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Hexamethylphosphoramide, based on the data on this page

What is Hexamethylphosphoramide?

Hexamethylphosphoric triamide is a phosphoramide. It has a role as a mutagen and an insect sterilant.

What is the CAS number of Hexamethylphosphoramide?

The CAS registry number of Hexamethylphosphoramide is 680-31-9. Other or deprecated CAS numbers: 630-31-9.

What is the molecular formula and weight of Hexamethylphosphoramide?

The molecular formula of Hexamethylphosphoramide is C6H18N3OP and its molar mass is 179.20 g/mol.

What is Hexamethylphosphoramide used for?

Processing solvent for aromatic polyamide fiber. De-icing additive for jet fuels, (experimental) chemosterilant for a number of insect pests, as a chemical mutagen.

Is Hexamethylphosphoramide hazardous?

Hexamethylphosphoramide carries the GHS signal word "Danger". Main hazards: may cause genetic defects, may cause cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Hexamethylphosphoramide?

Hexamethylphosphoramide is usually classified under HS code 294200 (XIII. OTHER ORGANIC COMPOUNDS, other organic compounds). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Hexamethylphosphoramide?

CompoundList lists 33 suppliers of Hexamethylphosphoramide in China, United States, India, Canada and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Hexamethylphosphoramide in India?

2 suppliers in India list Hexamethylphosphoramide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Hexamethylphosphoramide?

Suppliers quote Hexamethylphosphoramide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Hexamethylphosphoramide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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