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Flavonoids and polyphenols

Hispidol

Also known as 4',6-Dihydroxyaurone, (2Z)-6-hydroxy-2-[(4-hydroxyphenyl)methylidene]-1-benzofuran-3-one, Isoliquiritigenin metabolite M6

CAS 5786-54-9Formula C15H10O4Molar mass 254.24 g/mol
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Hispidol chemical structure, C15H10O4, CAS 5786-54-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
5786-54-9
Formula
C15H10O4
Molar mass
254.24 g/mol
HS code
293299
Category
Flavonoids and polyphenols

What is Hispidol?

Plain description, key identifiers and synonyms

Hispidol is a hydroxyaurone that is aurone substituted by hydroxy groups at positions 6 and 4' respectively. It has a role as a plant metabolite. It is functionally related to an aurone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2Z)-6-hydroxy-2-[(4-hydroxyphenyl)methylidene]-1-benzofuran-3-one
CAS number
5786-54-9Other or deprecated CAS: 92439-14-0
Molecular formula
C15H10O4
UNII
CS1235I0WT
INCI name
DIHYDROXYAURONE
InChIKey
KEZLDSPIRVZOKZ-AUWJEWJLSA-N
InChI
InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)7-14-15(18)12-6-5-11(17)8-13(12)19-14/h1-8,16-17H/b14-7-
Canonical SMILES
O=C1C(=Cc2ccc(O)cc2)Oc2cc(O)ccc21
Isomeric SMILES
C1=CC(=CC=C1/C=C\2/C(=O)C3=C(O2)C=C(C=C3)O)O

Synonyms

  • 4',6-Dihydroxyaurone
  • (2Z)-6-hydroxy-2-[(4-hydroxyphenyl)methylidene]-1-benzofuran-3-one
  • Isoliquiritigenin metabolite M6
  • 2-((4-Hydroxyphenyl)methylidene)-6-oxidanyl-1-benzofuran-3-one
  • (2Z)-6-Hydroxy-2-((4-hydroxyphenyl)methylene)-3(2H)-benzofuranone
  • 3(2H)-Benzofuranone, 6-hydroxy-2-((4-hydroxyphenyl)methylene)-, (2Z)-
  • 3(2H)-Benzofuranone, 6-hydroxy-2-[(4-hydroxyphenyl)methylene]-, (2Z)-
  • (2Z)-6-hydroxy-2-((4-hydroxyphenyl)methylidene)-1-benzofuran-3-one
  • 6-hydroxy-2-((4-hydroxyphenyl)methylidene)-1-benzofuran-3-one
  • (Z)-Hispidol
  • 6,4''-Dihydroxyaurone
  • (Z)-6-Hydroxy-2-(4-hydroxybenzylidene)benzofuran-3(2H)-one
  • (Z)-4',6-Dihydroxyaurone
  • (2Z)-6-hydroxy-2-[(4-hydroxyphenyl)methylidene]-2,3-dihydro-1-benzofuran-3-one
  • (2Z)-6-hydroxy-2-[(4-hydroxyphenyl)methylene]benzofuran-3-one
  • 6,4'-Dihydroxyaurone
  • Hispidol?
  • Hispidol, >98%
  • 6,4' -dihydroxy aurone
  • Hispidol, 10 mM in DMSO
  • Benzofuran-6-ol-3-one, 2-[4-hydroxybenzylidene]-
  • 2-(4''-Hydroxybenzylidene)-6-hydroxybenzofuran-3(2H)-one
  • (Z)-2-(4-hydroxybenzylidene)-6-hydroxybenzofuran-3(2H)-one
  • (2Z)-6-Hydroxy-2-(4-hydroxybenzylidene)-1-benzofuran-3(2H)-one #
  • (2Z)-6-hydroxy-2-[(4-hydroxyphenyl)methylidene]-1-benzofuran-3(2H)-one
Show all 26 synonyms
  • inhibit,Hispidol,TNF Receptor,Tumor Necrosis Factor Receptor,TNFR,Inhibitor

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
254.24 g/molcalc.
Exact mass
254.0579 Dacalc.
LogP (octanol/water)
2.71calc.
Topological polar surface area
66.76 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
1calc.
Heavy atoms
19calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C(=Cc2ccccc2)Oc2ccccc21

O=C1C(=Cc2ccccc2)Oc2ccccc21

3 rings, 17 atoms.

1,161 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Hispidol suppliers

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Hispidol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name DIHYDROXYAURONE(antioxidant)

Roles

  • eukaryotic metabolite
  • metabolite
  • plant metabolite

Cosmetic functions

  • Antioxidant

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Hispidol is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Hispidol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Hispidol, based on the data on this page

What is Hispidol?

Hispidol is a hydroxyaurone that is aurone substituted by hydroxy groups at positions 6 and 4' respectively. It has a role as a plant metabolite. It is functionally related to an aurone.

What is the CAS number of Hispidol?

The CAS registry number of Hispidol is 5786-54-9. Other or deprecated CAS numbers: 92439-14-0.

What is the molecular formula and weight of Hispidol?

The molecular formula of Hispidol is C15H10O4 and its molar mass is 254.24 g/mol.

What is Hispidol used for?

Known uses and roles of Hispidol include antioxidants in cosmetics and personal care, eukaryotic metabolite, metabolite, plant metabolite and antioxidant.

Is Hispidol hazardous?

No GHS hazard classification for Hispidol is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Hispidol?

Hispidol is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Hispidol?

Post a free request on CompoundList and suppliers of Hispidol will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Hispidol?

Suppliers quote Hispidol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Hispidol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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