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Heterocyclic compounds

Holomycin

Also known as N-Demethylthiolutin, N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide, N-(4,5-Dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide

CAS 488-04-0Formula C7H6N2O2S2Molar mass 214.27 g/mol
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Holomycin chemical structure, C7H6N2O2S2, CAS 488-04-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
488-04-0
Formula
C7H6N2O2S2
Molar mass
214.27 g/mol
HS code
293499
Category
Heterocyclic compounds

What is Holomycin?

Plain description, key identifiers and synonyms

Holomycin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties. It has a role as an antibacterial agent, an antineoplastic agent, an EC 2.7.7.6 (RNA polymerase) inhibitor, a chelator, a marine metabolite and a bacterial metabolite. It is a dithiolopyrrolone antibiotic and a member of acetamides.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide
CAS number
488-04-0 CAS number cross-checked
Molecular formula
C7H6N2O2S2
UNII
44CF65YLF8
MDL number
MFCD01670588
InChIKey
HBUNPJGMNVQSBX-UHFFFAOYSA-N
InChI
InChI=1S/C7H6N2O2S2/c1-3(10)8-5-6-4(2-12-13-6)9-7(5)11/h2H,1H3,(H,8,10)(H,9,11)
SMILES (canonical and isomeric)
CC(=O)NC1=C2C(=CSS2)NC1=O

Synonyms

  • N-Demethylthiolutin
  • N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide
  • N-(4,5-Dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide
  • 6-Acetamido-1,2-dithiolo(4,3-b)pyrrol-5(4H)-one
  • N-(4,5-Dihydro-5-oxo-1,2-dithiolo(4,3-b)pyrrol-6-yl)acetamide
  • N-(4,5-Dihydro-5-oxo-1,2-dithiolo-(4,3-b)pyrrol-6-yl)acetamide
  • 6-acetamido-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one
  • N-(5-oxo-4H-Dithiolo(4,3-b)pyrrol-6-yl)acetamide
  • N-(4,5-dihydro-5-oxo-1,2-dithiolo-[4,3-b]pyrrol-6-yl)acetamide
  • N-{5-oxo-4H,5H-[1,2]dithiolo[4,3-b]pyrrol-6-yl}acetamide
  • N-(5-Oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetamide
  • N-(5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetamide
  • 1,2-Dithiolo(4,3-b)pyrrol-5(4H)-one, 6-acetamido-
  • Acetamide, N-(4,5-dihydro-5-oxo-1,2-dithiolo(4,3-b)pyrrol-6-yl)-
  • N-(5-oxo-4H-dithiolo[3,4-d]pyrrol-6-yl)acetamide
  • 6-(acetylamino)-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one
  • 1,2-Dithiolo(4,3-b)pyrrol-5(4H)-one, 6-acetamido
  • 1,2-Dithiolo(4,3-b)pyrrol-5(4H)-one, 6-(acetylamino)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
214.27 g/molcalc.
Exact mass
213.9871 Dacalc.
LogP (octanol/water)
1.56calc.
Topological polar surface area
61.96 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
1calc.
Heavy atoms
13calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.14calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cc2sscc-2[nH]1

O=c1cc2sscc-2[nH]1

2 rings, 9 atoms.

14 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Holomycin suppliers

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Holomycin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antibacterial agent
  • antimicrobial agent
  • antineoplastic agent
  • bacterial metabolite
  • chelator
  • enzyme inhibitor
  • ligand
  • marine metabolite
  • metabolite
  • pharmaceutical
  • prokaryotic metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Holomycin is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Holomycin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Holomycin, based on the data on this page

What is Holomycin?

Holomycin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties.

What is the CAS number of Holomycin?

The CAS registry number of Holomycin is 488-04-0.

What is the molecular formula and weight of Holomycin?

The molecular formula of Holomycin is C7H6N2O2S2 and its molar mass is 214.27 g/mol.

What is Holomycin used for?

Known uses and roles of Holomycin include antibacterial agent, antimicrobial agent, antineoplastic agent, bacterial metabolite, chelator and 6 more.

Is Holomycin hazardous?

No GHS hazard classification for Holomycin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Holomycin?

Holomycin is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Holomycin?

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What is the price of Holomycin?

Suppliers quote Holomycin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Holomycin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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