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Antibiotics and anti-infectives

Hycanthone

Also known as Hycanthon, Hicantona, Lucanthone metabolite

CAS 3105-97-3Formula C20H24N2O2SMolar mass 356.49 g/molEC 221-463-7
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 4 suppliers listed
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Hycanthone chemical structure, C20H24N2O2S, CAS 3105-97-3
2D chemical structure

Key facts

What buyers check first

All properties
Physical form
Powder
Melting point
100.6 to 102.8
Solubility
Highly soluble
HS code
293499
Category
Antibiotics and anti-infectives
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Hycanthone?

Plain description, key identifiers and synonyms

Hycanthone is a thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel. It has a role as a mutagen and a schistosomicide drug. It is functionally related to a lucanthone. It is a conjugate base of a hycanthone(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[2-(diethylamino)ethylamino]-4-(hydroxymethyl)thioxanthen-9-one
CAS number
3105-97-3 CAS number cross-checked
EC number
221-463-7
Molecular formula
C20H24N2O2S
UNII
2BXX5EVN2A
MDL number
MFCD00083383
InChIKey
MFZWMTSUNYWVBU-UHFFFAOYSA-N
InChI
InChI=1S/C20H24N2O2S/c1-3-22(4-2)12-11-21-16-10-9-14(13-23)20-18(16)19(24)15-7-5-6-8-17(15)25-20/h5-10,21,23H,3-4,11-13H2,1-2H3
SMILES (canonical and isomeric)
CCN(CC)CCNC1=C2C(=C(C=C1)CO)SC3=CC=CC=C3C2=O

Synonyms

  • Hycanthon
  • Hicantona
  • Lucanthone metabolite
  • 1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)-9H-thioxanthen-9-one
  • Hycanthonum
  • WIN 24933
  • WIN 24,933
  • 1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)thioxanthen-9-one
  • 1-{[2-(Diethylamino)ethyl]amino}-4-(hydroxymethyl)-9H-thioxanthen-9-one
  • 9H-Thioxanthen-9-one, 1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-
  • 1-[(2-[Diethylamino]ethyl)amino]-4-[hydroxymethyl]-9H-thioxanthen-9-one
  • 1-[[2-(Diethylamino)ethyl]amino]-4-(hydroxymethyl)-9H-thioxanthen-9-one
  • Thioxanthen-9-one, 1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-
  • 9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-(hydroxymethyl)-
  • 1-[[2-(Diethylamino)ethyl]amino]-4-(hydroxymethyl)thioxanthen-9-one
  • Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-(hydroxymethyl)-
  • Hycanthone?
  • 1-(2-diethylaminoethylamino)-4-(hydroxymethyl)thioxanthen-9-one
  • 1-[2-(diethylamino)ethylamino]-4-(hydroxymethyl)thioxanthen-9-one
  • QHM
  • Etrenol (Salt/Mix)
  • DivK1c_000480
  • Hycanthone mesylate (Salt/Mix)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Powderexp.
Melting point
100.6 to 102.8exp.
Solubility
Highly solubleexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
356.49 g/molcalc.
Exact mass
356.1558 Dacalc.
LogP (octanol/water)
3.66calc.
Topological polar surface area
52.57 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
7calc.
Heavy atoms
25calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.35calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1c2ccccc2sc2ccccc12

O=c1c2ccccc2sc2ccccc12

3 rings, 15 atoms, the Thioxanthone ring system.

254 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H332Harmful if inhaled.
  • H350May cause cancer.
Precautionary statements (16)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Hycanthone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 4 suppliers
4 of 4 offers
  • Ambinter
    France, OrleansUnclaimed profile
    HycanthoneGrade, purity and minimum order on request
    Price on request
    View
  • Clearsynth
    United States, San DiegoUnclaimed profile
    HycanthoneGrade, purity and minimum order on request
    Price on request
    View
  • Matrix Scientific
    United States, ElginUnclaimed profile
    HycanthoneGrade, purity and minimum order on request
    Price on request
    View
  • Thoreauchem
    China, HongKongUnclaimed profile
    HycanthoneGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

4 suppliers in 3 countries

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Hycanthone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Schistosomicides

Roles

  • aetiopathogenetic role
  • anthelminthic drug
  • antiinfective agent
  • antiparasitic agent
  • antiplatyhelmintic drug
  • genotoxin
  • mutagen
  • pharmaceutical
  • schistosomicide drug

Pharmacology

Hycanthone is a thioxanthene derivative of lucanthone with anti-schistosomal activity and potential antineoplastic activity. Hycanthone interferes with parasite nerve function, resulting in parasite paralysis and death. This agent also intercalates into DNA and inhibits RNA synthesis in vitro. (NCI04)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Hycanthone is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Hycanthone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Hycanthone, based on the data on this page

What is Hycanthone?

Hycanthone is a thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position.

What is the CAS number of Hycanthone?

The CAS registry number of Hycanthone is 3105-97-3.

What is the molecular formula and weight of Hycanthone?

The molecular formula of Hycanthone is C20H24N2O2S and its molar mass is 356.49 g/mol.

What is Hycanthone used for?

Known uses and roles of Hycanthone include aetiopathogenetic role, anthelminthic drug, antiinfective agent, antiparasitic agent, antiplatyhelmintic drug and 5 more.

Is Hycanthone hazardous?

Hycanthone carries the GHS signal word "Danger". Main hazards: harmful if swallowed, harmful in contact with skin, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Hycanthone?

Hycanthone is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Hycanthone?

CompoundList lists 4 suppliers of Hycanthone in United States, China and France. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Hycanthone?

Suppliers quote Hycanthone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Hycanthone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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