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Antibiotics and anti-infectives

Lucanthone

Also known as Lucanthonum, Lucantona, 1-((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one

CAS 479-50-5Formula C20H24N2OSMolar mass 340.49 g/molEC 207-532-4
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Lucanthone chemical structure, C20H24N2OS, CAS 479-50-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
479-50-5
Formula
C20H24N2OS
Molar mass
340.49 g/mol
EC number
207-532-4
HS code
293499
Category
Antibiotics and anti-infectives

What is Lucanthone?

Plain description, key identifiers and synonyms

Lucanthone is a thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone. It has a role as a mutagen, an antineoplastic agent, a schistosomicide drug, a photosensitizing agent, a prodrug, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor and an adjuvant.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[2-(diethylamino)ethylamino]-4-methylthioxanthen-9-one
CAS number
479-50-5 CAS number cross-checkedOther or deprecated CAS: 548-57-2
EC number
207-532-4
Molecular formula
C20H24N2OS
UNII
FC6D57000M
InChIKey
FBQPGGIHOFZRGH-UHFFFAOYSA-N
InChI
InChI=1S/C20H24N2OS/c1-4-22(5-2)13-12-21-16-11-10-14(3)20-18(16)19(23)15-8-6-7-9-17(15)24-20/h6-11,21H,4-5,12-13H2,1-3H3
SMILES (canonical and isomeric)
CCN(CC)CCNC1=C2C(=C(C=C1)C)SC3=CC=CC=C3C2=O

Synonyms

  • Lucanthonum
  • Lucantona
  • 1-((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one
  • 1-((2-(diethylamino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one
  • 1-{[2-(Diethylamino)ethyl]amino}-4-methyl-9H-thioxanthen-9-one
  • 9H-Thioxanthen-9-one, 1-((2-(diethylamino)ethyl)amino)-4-methyl-
  • 1-diethylaminoethylethylamino-4-methyl-thioxanthenone
  • 1-{[2-(diethylamino)ethyl]amino}-4-methylthioxanthen-9-one
  • 9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-methyl-
  • Lucanthon
  • 1-[2-(diethylamino)ethylamino]-4-methylthioxanthen-9-one
  • 1-((2-(Diethylamino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one , Lucanthone
  • 1-[[2-(Diethylamino)ethyl]amino]-4-methylthioxanthone
  • Lucanthone-API
  • 5-18-11-00503 (Beilstein Handbook Reference)
  • 1-[2-(diethylamino)ethylamino]-4-methyl-thioxanthen-9-one
  • Thioxanthen-9-one, 1-((2-(diethylamino)ethyl)amino)-4-methyl-
  • 1-(2-diethylaminoethylamino)-4-methyl-thioxanthen-9-one
  • 1-(2-Diethylaminoethylamino)-4-methylthiaxanthone

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
340.49 g/molcalc.
Exact mass
340.1609 Dacalc.
LogP (octanol/water)
4.48calc.
Topological polar surface area
32.34 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
6calc.
Heavy atoms
24calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.35calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1c2ccccc2sc2ccccc12

O=c1c2ccccc2sc2ccccc12

3 rings, 15 atoms, the Thioxanthone ring system.

254 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Lucanthone suppliers

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Where suppliers are based

1 supplier in 1 country

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Lucanthone price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Schistosomicides

Roles

  • adjuvant
  • aetiopathogenetic role
  • anthelminthic drug
  • antiinfective agent
  • antineoplastic agent
  • antiparasitic agent
  • antiplatyhelmintic drug
  • enzyme inhibitor
  • genotoxin
  • mutagen
  • pharmaceutical
  • photosensitizing agent
  • pro-agent
  • prodrug
  • schistosomicide drug
  • topoisomerase inhibitor

Pharmacology

Lucanthone is an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APEX1 or APE1), with anti-schistosomal and potential antineoplastic activity. Lucanthone intercalates DNA and interferes with the activity of topoisomerases I and II during replication and transcription, thereby inhibiting the synthesis of macromolecules. In addition, this agent specifically inhibits the endonuclease activity of APE1, without affecting its redox activity, resulting in un-repaired DNA strand breaks which may induce apoptosis.

Read more

Therefore, lucanthone may sensitize tumor cells to radiation and chemotherapy. Furthermore, lucanthone inhibits autophagy through the disruption of lysosomal function. The multifunctional nuclease APE1 is a key component for DNA repair, its expression is often correlated with tumor cell resistance to radio- and chemotherapy.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Lucanthone is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Lucanthone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Lucanthone, based on the data on this page

What is Lucanthone?

Lucanthone is a thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone.

What is the CAS number of Lucanthone?

The CAS registry number of Lucanthone is 479-50-5. Other or deprecated CAS numbers: 548-57-2.

What is the molecular formula and weight of Lucanthone?

The molecular formula of Lucanthone is C20H24N2OS and its molar mass is 340.49 g/mol.

What is Lucanthone used for?

Known uses and roles of Lucanthone include adjuvant, aetiopathogenetic role, anthelminthic drug, antiinfective agent, antineoplastic agent and 12 more.

Is Lucanthone hazardous?

No GHS hazard classification for Lucanthone is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Lucanthone?

Lucanthone is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Lucanthone?

CompoundList lists 1 supplier of Lucanthone in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Lucanthone?

Suppliers quote Lucanthone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Lucanthone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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