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Analgesics and anti-inflammatories

Hydrocodone

Also known as Dihydrocodeinone, Hydrocodon, Hydrocone

CAS 125-29-1Formula C18H21NO3Molar mass 299.37 g/molEC 204-733-9
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard, Hazardous to the environment Prohibited, not for trade Drug substance
Why it is not for trade
Hydrocodone chemical structure, C18H21NO3, CAS 125-29-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Prisms from alcohol
Melting point
198 °C
Flash point
9.7 °C
Solubility
Soluble in acetone, ethyl acetate, chloroform
HS code
293911
Category
Analgesics and anti-inflammatories

What is Hydrocodone?

Plain description, key identifiers and synonyms

Hydrocodone is a morphinane-like compound that is a semi-synthetic opioid synthesized from codeine. It has a role as an opioid analgesic, an antitussive and a mu-opioid receptor agonist. It is an organic heteropentacyclic compound and a morphinane-like compound. It derives from a hydride of a morphinan.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
CAS number
125-29-1 CAS number cross-checkedOther or deprecated CAS: 50678-79-0
EC number
204-733-9
Molecular formula
C18H21NO3
UNII
6YKS4Y3WQ7
InChIKey
LLPOLZWFYMWNKH-CMKMFDCUSA-N
InChI
InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-12,17H,4-5,7-9H2,1-2H3/t11-,12+,17-,18-/m0/s1
Canonical SMILES
COc1ccc2c3c1OC1C(=O)CCC4C(C2)N(C)CCC314
Isomeric SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3C(=O)CC4

Synonyms

  • Dihydrocodeinone
  • Hydrocodon
  • Hydrocone
  • Hydroconum
  • Bekadid
  • Multacodin
  • (-)-Dihydrocodeinone
  • hidrocodona
  • Idrocodone
  • DICO
  • Hydrocodonum
  • 4,5-alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one
  • 6-Oxo-3-methoxy-N-methyl-4,5-epoxymorphinan
  • (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
  • Morphinan-6-one, 4,5alpha-epoxy-3-methoxy-17-methyl-
  • Morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl-
  • Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha)-
  • Hydrocodeinonebitartrate
  • (1S,5R,13R,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo(9.6.1.0^(1,13).0^(5,17).0^(7,18))octadeca-7(18),8,10-trien-14-one
  • (1S,5R,13R,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one
  • (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro(3,2-e)isoquinolin-7-one
  • (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro(3,2-e)isoquinoline-7-one
  • (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one
  • Hydrocodone Tartrate (1:1), Hydrate (2:5)
  • (1S,5R,13R,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo(9.6.1.01,13.05,17.07,18)octadeca-7(18),8,10-trien-14-one
Show all 32 synonyms
  • Codinovo
  • Dicodid
  • Codeinone, dihydro-
  • 4,5alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one
  • Hydrocodone (INN)
  • Hydrocodone polistirex
  • opioid1

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Prisms from alcoholexp.
Melting point
198 °Cexp.
Flash point
9.7 °Cexp.
Solubility
Soluble in acetone, ethyl acetate, chloroformexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
299.37 g/molcalc.
Exact mass
299.1521 Dacalc.
LogP (octanol/water)
1.93calc.
Topological polar surface area
38.77 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
1calc.
Heavy atoms
22calc.
Rings
5calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.61calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC2C3Cc4cccc5c4C2(CCN3)C1O5

O=C1CCC2C3Cc4cccc5c4C2(CCN3)C1O5

5 rings, 19 atoms.

148 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H317May cause an allergic skin reaction.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H400Very toxic to aquatic life.
Precautionary statements (21)
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403Store in a well-ventilated place.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Hydrocodone suppliers

Trading restrictions apply to this substance

Narcotic drug

Hydrocodone is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2939.11 (opium alkaloids and their derivatives)

Our policy on controlled substances

Hydrocodone price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

This is a (DEA:) Schedule II controlled substance.

Semisynthetic opioid antitussive and analgesic.

Veterinary medication:.

Analgesics, Opioid, Antitussive Agents, Narcotics.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Analgesics, Opioid
  • Antitussive Agents
  • Narcotics

Roles

  • agonist
  • analgesic
  • antitussive
  • mu-opioid agent
  • mu-opioid receptor agonist
  • neurotransmitter agent
  • opioid agent
  • opioid analgesic
  • opioid receptor agonist
  • pharmaceutical

Functional uses

  • Pharmaceutical

Pharmacology

Hydrocodone is an Opioid Agonist. The mechanism of action of hydrocodone is as an Opioid Agonist.

How it is made

Synthetic alkaloid, 7,8-dihydrocodeinone, is prepared ... By catalytic rearrangement of codeine or by controlled hydrolysis & oxidation of dihydrothebaine. (Hydrocodone bitartrate, NF)

For the synthesis of hydrocodone, codeine is catalytically rearranged by heating with palladium or platinum in alcoholic or aqueous acidic solution.

Industrial preparation from dihydrocodeine: K. Pfister, M. Tishler, United States of America patent 2715626 (1955 to Merck & Co.).

Regulatory status

Inventories, regulations and trade controls that list this substance

Narcotic drug

Hydrocodone is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2939.11 (opium alkaloids and their derivatives)

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled narcotic drug

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Hydrocodone is traded under.

HS 2939.11Exact HS code

Concentrates of poppy straw, buprenorphine (INN), codeine, dihydrocodeine (INN)…

World exports in 2024
$246M
−3.8% vs 2023, imports $339M
2019 to 2024
Top exporters
  1. United Kingdom33.3%
  2. Spain21.3%
  3. Czech Republic8.6%
Top importers
  1. United States30.8%
  2. United Kingdom13.2%
  3. Germany6.3%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Hydrocodone is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Hydrocodone, based on the data on this page

What is Hydrocodone?

Hydrocodone is a morphinane-like compound that is a semi-synthetic opioid synthesized from codeine. It has a role as an opioid analgesic, an antitussive and a mu-opioid receptor agonist. It is an organic heteropentacyclic compound and a morphinane-like compound. It derives from a hydride of a morphinan.

What is the CAS number of Hydrocodone?

The CAS registry number of Hydrocodone is 125-29-1. Other or deprecated CAS numbers: 50678-79-0.

What is the molecular formula and weight of Hydrocodone?

The molecular formula of Hydrocodone is C18H21NO3 and its molar mass is 299.37 g/mol.

What is Hydrocodone used for?

This is a (DEA:) Schedule II controlled substance. Semisynthetic opioid antitussive and analgesic. Veterinary medication:. Analgesics, Opioid, Antitussive Agents, Narcotics. Use classes: Pharmaceuticals.

Is Hydrocodone hazardous?

Hydrocodone carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Hydrocodone?

Hydrocodone is usually classified under HS code 293911 (Concentrates of poppy straw, buprenorphine (INN), codeine, dihydrocodeine (INN)…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Hydrocodone on CompoundList?

No. Hydrocodone is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Hydrocodone

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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