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Analgesics and anti-inflammatories

Hydromorphone

Also known as Dihydromorphinone, Dimorphone, Hydromorphon

CAS 466-99-9Formula C17H19NO3Molar mass 285.34 g/molEC 207-383-5
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard Prohibited, not for trade Drug substance
Why it is not for trade
Hydromorphone chemical structure, C17H19NO3, CAS 466-99-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from ethanol
Melting point
266 to 267
Solubility
In water, 1,931 mg/L at 25 °C
HS code
293911
Category
Analgesics and anti-inflammatories

What is Hydromorphone?

Plain description, key identifiers and synonyms

Hydromorphone is a morphinane alkaloid that is a hydrogenated ketone derivative of morphine. A semi-synthetic drug, it is a centrally acting pain medication of the opioid class. It has a role as an opioid analgesic and a mu-opioid receptor agonist. It is a morphinane alkaloid and an organic heteropentacyclic compound. It derives from a hydride of a morphinan.

Hydromorphone is an opioid drug used for pain relief.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
CAS number
466-99-9 CAS number cross-checked
EC number
207-383-5
Molecular formula
C17H19NO3
UNII
Q812464R06
InChIKey
WVLOADHCBXTIJK-YNHQPCIGSA-N
InChI
InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1
Canonical SMILES
CN1CCC23c4c5ccc(O)c4OC2C(=O)CCC3C1C5
Isomeric SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=O)CC4

Synonyms

  • Dihydromorphinone
  • Dimorphone
  • Hydromorphon
  • Idromorfone
  • Novolaudon
  • Dihydromorfinon
  • Hidromorfona
  • Hydromorfona
  • Laudacon
  • 7,8-Dihydromorphinone
  • Dilaudid Oros
  • Hydromorphonum
  • Morphinone, dihydro-
  • 6-Deoxy-7,8-dihydro-6-oxomorphine
  • Jurnista
  • 4,5-Epoxy-3-hydroxy-17-methylmorphinan-6-one
  • 4,5alpha-Epoxy-3-hydroxy-17-methyl-6-morphinanone
  • (-)-Hydromorphone
  • (-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphinan-6-one
  • Morphinan-6-one, 4,5-alpha-epoxy-3-hydroxy-17-methyl-
  • Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, (5alpha)-
  • Morphinan-6-one, 4,5alpha-epoxy-3-hydroxy-17-methyl-
  • (4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one
  • (1S,5R,13R,17R)-10-hydroxy-4-methyl-12-oxa-4-azapentacyclo(9.6.1.0^(1,13).0^(5,17).0^(7,18))octadeca-7(18),8,10-trien-14-one
  • (1S,5R,13R,17R)-10-hydroxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one
Show all 32 synonyms
  • (4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro(3,2-e)isoquinoline-7-one
  • (1S,5R,13R,17R)-10-hydroxy-4-methyl-12-oxa-4-azapentacyclo(9.6.1.01,13.05,17.07,18)octadeca-7(18),8,10-trien-14-one
  • DiMo
  • Dilaudid
  • Hydromorphone (INN)
  • 3-hydroxy-17-methyl-4,5alpha-epoxymorphinan-6-one
  • DEA No. 9150

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from ethanolexp.
Odour
Odorlessexp.
Melting point
266 to 267exp.
Solubility
In water, 1,931 mg/L at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
285.34 g/molcalc.
Exact mass
285.1365 Dacalc.
LogP (octanol/water)
1.63calc.
Topological polar surface area
49.77 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
0calc.
Heavy atoms
21calc.
Rings
5calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.59calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC2C3Cc4cccc5c4C2(CCN3)C1O5

O=C1CCC2C3Cc4cccc5c4C2(CCN3)C1O5

5 rings, 19 atoms.

148 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H317May cause an allergic skin reaction.
  • H331Toxic if inhaled.
  • H336May cause drowsiness or dizziness.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (20)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Hydromorphone suppliers

Trading restrictions apply to this substance

Narcotic drug

Hydromorphone is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2939.11 (opium alkaloids and their derivatives)

Our policy on controlled substances

Hydromorphone price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Analgesics, Opioid, Narcotics.

Hydromorphone (DEA Code Number: 9150) is a Schedule II controlled substance.

Schedule II Controlled Substance: (A) The drug or other substance has a high potential for abuse, (B) The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions, and (C) Abuse of the drug or other substances may lead to severe psychological or physical dependence.

Analgesic drug.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Analgesics, Opioid
  • Narcotics

Roles

  • agonist
  • analgesic
  • mu-opioid agent
  • mu-opioid receptor agonist
  • neurotransmitter agent
  • opioid agent
  • opioid analgesic
  • opioid receptor agonist
  • pharmaceutical

Functional uses

  • Pharmaceutical

Pharmacology

Hydromorphone is an Opioid Agonist. The mechanism of action of hydromorphone is as a Full Opioid Agonist.

How it is made

Hydromorphone can be prepared by catalytic rearrangement of morphine or by oxidation of the aliphatic hydroxyl group of dihydromorphine.

Morphine is hydrogenated over a palladium catalyst, and the resulting dihydromorphine is oxidized with benzophenone and potassium tert-butoxide. Alternative oxidants are cyclohexanone with aluminum tri(tert-butoxide) or aluminum triphenoxide.

Preparation from morphine: German patent 365683, German patent 623821 (1922, 1936 both to Knoll), by oxidation of dihydromorphine.

Regulatory status

Inventories, regulations and trade controls that list this substance

Narcotic drug

Hydromorphone is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2939.11 (opium alkaloids and their derivatives)

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled narcotic drug

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Hydromorphone is traded under.

HS 2939.11Exact HS code

Concentrates of poppy straw, buprenorphine (INN), codeine, dihydrocodeine (INN)…

World exports in 2024
$246M
−3.8% vs 2023, imports $339M
2019 to 2024
Top exporters
  1. United Kingdom33.3%
  2. Spain21.3%
  3. Czech Republic8.6%
Top importers
  1. United States30.8%
  2. United Kingdom13.2%
  3. Germany6.3%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Hydromorphone is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Hydromorphone, based on the data on this page

What is Hydromorphone?

Hydromorphone is a morphinane alkaloid that is a hydrogenated ketone derivative of morphine. A semi-synthetic drug, it is a centrally acting pain medication of the opioid class. It has a role as an opioid analgesic and a mu-opioid receptor agonist. It is a morphinane alkaloid and an organic heteropentacyclic compound.

What is the CAS number of Hydromorphone?

The CAS registry number of Hydromorphone is 466-99-9.

What is the molecular formula and weight of Hydromorphone?

The molecular formula of Hydromorphone is C17H19NO3 and its molar mass is 285.34 g/mol.

What is Hydromorphone used for?

Analgesics, Opioid, Narcotics. Hydromorphone (DEA Code Number: 9150) is a Schedule II controlled substance.

Is Hydromorphone hazardous?

Hydromorphone carries the GHS signal word "Danger". Main hazards: toxic if swallowed, may cause an allergic skin reaction, toxic if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Hydromorphone?

Hydromorphone is usually classified under HS code 293911 (Concentrates of poppy straw, buprenorphine (INN), codeine, dihydrocodeine (INN)…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Hydromorphone on CompoundList?

No. Hydromorphone is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Hydromorphone

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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