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Oncology and immunology drugs

Hydroxyurea

Also known as Hydroxycarbamide, N-Hydroxyurea, Hydrea

CAS 127-07-1Formula CH4N2O2Molar mass 76.06 g/molEC 204-821-7
GHS signal word: Danger. Pictograms: Serious health hazard 132 suppliers listed Drug substance
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Hydroxyurea chemical structure, CH4N2O2, CAS 127-07-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Needles from alcohol
Melting point
141 °C
Boiling point
Decomposes
Solubility
Freely soluble in water /1.0 × 10⁺⁶ mg/L at 25 °C/
HS code
292800
Category
Oncology and immunology drugs
UN number
UN 2811
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Hydroxyurea?

Plain description, key identifiers and synonyms

Hydroxyurea is a member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease. It has a role as an antimetabolite, an antineoplastic agent, a radical scavenger, an immunomodulator, a genotoxin, a teratogenic agent, a DNA synthesis inhibitor, an antimitotic and an EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor. It is a member of ureas and a one-carbon compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
hydroxyurea
CAS number
127-07-1 CAS number cross-checkedOther or deprecated CAS: 8029-68-3
EC number
204-821-7
Molecular formula
CH4N2O2
UNII
X6Q56QN5QC
MDL number
MFCD00007943
INCI name
ICHTHAMMOL
InChIKey
VSNHCAURESNICA-UHFFFAOYSA-N
InChI
InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
SMILES (canonical and isomeric)
C(=O)(N)NO

Synonyms

  • Hydroxycarbamide
  • N-Hydroxyurea
  • Hydrea
  • Oxyurea
  • Carbamoyl oxime
  • Carbamohydroxamic acid
  • Carbamohydroximic acid
  • Litalir
  • Hydroxycarbamine
  • Urea, hydroxy-
  • Onco-carbide
  • Biosupressin
  • Droxia
  • Hidrix
  • Hydura
  • Carbamyl hydroxamate
  • Hydurea
  • N-Carbamoylhydroxylamine
  • Siklos
  • Hydroxicarbamidum
  • Hydroxylurea
  • Hidroxicarbamida
  • Xromi
  • Hydroxyharnstoff
  • Hydroxycarbamidum
Show all 38 synonyms
  • N-Hydroxymocovina
  • Carbamohydroxyamic acid
  • SQ 1089
  • Hydroxylamine, N-carbamoyl-
  • Hydroxycarbamid
  • Oncocarbide
  • Idrossicarbamide
  • Hydroxylamine, N-(aminocarbonyl)-
  • SK 22591
  • 4-03-00-00170 (Beilstein Handbook Reference)
  • idroxicarbamide
  • Oxeron
  • Syrea

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Needles from alcoholexp.
Melting point
141 °Cexp.
Boiling point
Decomposesexp.
Solubility
Freely soluble in water /1.0 × 10⁺⁶ mg/L at 25 °C/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
76.06 g/molcalc.
Exact mass
76.0273 Dacalc.
LogP (octanol/water)
-0.96calc.
Topological polar surface area
75.35 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
0calc.
Heavy atoms
5calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H340May cause genetic defects.
  • H360May damage fertility or the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2811

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Hydroxyurea suppliers

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All 132 suppliers
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Where suppliers are based

132 suppliers in 19 countries

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Hydroxyurea price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Antineoplastic Agents, Antisickling Agents, Enzyme Inhibitors, Nucleic Acid Synthesis Inhibitors.

Veterinary medication:.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name ICHTHAMMOL(antimicrobial)

Pharmacological actions

  • Antineoplastic Agents
  • Antisickling Agents
  • Enzyme Inhibitors
  • Nucleic Acid Synthesis Inhibitors

Roles

  • DNA synthesis inhibitor
  • aetiopathogenetic role
  • anti-HIV agent
  • anti-anaemic agent
  • antifibrotic agent
  • antihypertensive agent
  • antimetabolite
  • antimicrobial agent
  • antimitotic
  • antineoplastic agent
  • antioxidant
  • antiviral agent
  • cardiovascular drug
  • enzyme inhibitor
  • genotoxin
  • immunomodulator
  • immunosuppressive agent
  • pathway inhibitor
  • pharmaceutical
  • radical scavenger
  • teratogenic agent

Functional uses

  • Biocide

Cosmetic functions

  • Antimicrobial

Pharmacology

Hydroxyurea is an Antimetabolite.

How it is made

By interaction of hydroxylamine hydrochloride and potassium cyanide.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Hydroxyurea is traded under.

HS 2928.00Indicative HS code

Organic derivatives of hydrazine or of hydroxylamine

World exports in 2024
$1.38B
−9.0% vs 2023, imports $1.52B
2019 to 2024
Top exporters
  1. Switzerland * partner reported44.0%
  2. China18.4%
  3. Italy9.4%
Top importers
  1. Brazil21.8%
  2. United States12.8%
  3. Italy10.8%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Hydroxyurea is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Hydroxyurea, based on the data on this page

What is Hydroxyurea?

Hydroxyurea is a member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.

What is the CAS number of Hydroxyurea?

The CAS registry number of Hydroxyurea is 127-07-1. Other or deprecated CAS numbers: 8029-68-3.

What is the molecular formula and weight of Hydroxyurea?

The molecular formula of Hydroxyurea is CH4N2O2 and its molar mass is 76.06 g/mol.

What is Hydroxyurea used for?

Antineoplastic Agents, Antisickling Agents, Enzyme Inhibitors, Nucleic Acid Synthesis Inhibitors. Veterinary medication:. Use classes: Cosmetics.

Is Hydroxyurea hazardous?

Hydroxyurea carries the GHS signal word "Danger". Main hazards: may cause genetic defects, may damage fertility or the unborn child, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Hydroxyurea?

Hydroxyurea is usually classified under HS code 292800 (Organic derivatives of hydrazine or of hydroxylamine). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Hydroxyurea?

CompoundList lists 132 suppliers of Hydroxyurea in China, United States, India, Germany and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Hydroxyurea in India?

13 suppliers in India list Hydroxyurea on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Hydroxyurea?

Suppliers quote Hydroxyurea on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Hydroxyurea

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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