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Oncology and immunology drugs

Hydroxyurea safety data

GHS hazards, precautions, first aid, handling and transport for Hydroxyurea. A classification summary, not a safety data sheet.
CAS 127-07-1Formula CH4N2O2

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

GHS classification

Pictograms, signal word and hazard classes of the GHS classification

GHS08: Serious health hazard
Serious health hazard
Signal word
Danger

Hazard classes and categories

  • Muta. 1A/1B
  • Repr. 1A/1B
  • Repr. 2

Hazard statements

H codes grouped by type. Percentages show the share of classification notifications that report the statement

Health hazards

  • H340May cause genetic defects.
  • H360May damage fertility or the unborn child.
  • H361Suspected of damaging fertility or the unborn child.

Precautionary statements

P codes for prevention, response, storage and disposal

Prevention

  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.

Response

  • P318If exposed or concerned, get medical advice.

Storage

  • P405Store locked up.

Disposal

  • P501Dispose of contents and container in accordance with local regulations.

First aid

General first aid measures. Get medical advice if you feel unwell

If inhaled
IMMEDIATELY leave the contaminated area, take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used, if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
Skin contact
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
Eye contact
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
If swallowed
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

Handling, storage and disposal

Summaries only, follow the supplier SDS for your grade

Safe handling

Eye/face protection: Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection: Handle with gloves.

Storage

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature 2 - 8 °C. Moisture sensitive. Keep in a dry place. Store at 20 deg to 25 °C (68 deg to 77 °F)

Disposal

SRP: Expired or waste pharmaceuticals shall carefully take into consideration applicable DEA, EPA, and FDA regulations. It is not appropriate to dispose by flushing the pharmaceutical down the toilet or discarding to trash. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.

Exposure limits and toxicity

Occupational exposure limits and toxicity data

During a 2-year period, 26 patients taking hydroxyurea for more than 6 months who had consultations at the dermatology department were systematically examined regarding cutaneous side effects. All but one had cutaneous side-effects, including dryness, moderate alopecia, increased skin pigmentation, melanonychia, cutaneous atrophy, leg ulcers, plantar keratoderma, pseudodermatomyositis, lichen planus-like eruption on the dorsum of the hands actinic keratosis, squamous cell carcinomas, and mouth ulcerations.

Transport information

UN dangerous goods classification for road, sea and air

UN number
UN 2811

Shipping rules depend on mode, quantity and packaging. Confirm the classification with the supplier SDS and your freight forwarder.

Supplier safety data sheets

SDS documents uploaded by suppliers who list this chemical

No supplier has uploaded an SDS for Hydroxyurea yet. Suppliers usually send one with their quote. Request quotes

Safety questions

Quick answers about handling Hydroxyurea safely

Is Hydroxyurea hazardous?

Hydroxyurea carries the GHS signal word "Danger". Main hazards: may cause genetic defects, may damage fertility or the unborn child, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

Which GHS pictograms apply to Hydroxyurea?

The GHS classification of Hydroxyurea shows 1 pictogram: GHS08 (serious health hazard).

What is the UN number of Hydroxyurea?

Hydroxyurea is transported under UN 2811. Check the supplier SDS and the current ADR, IMDG or IATA rules before shipping.

How should Hydroxyurea be stored?

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature 2 - 8 °C. Moisture sensitive. Keep in a dry place. Store at 20 deg to 25 °C (68 deg to 77 °F)

Where can I get the SDS for Hydroxyurea?

Ask the supplier for the safety data sheet of the exact grade you buy. Suppliers on CompoundList can attach their SDS to listings and send it with a quote. This page is a GHS classification summary, not an SDS.

GHS classification summary, not an SDS. Always check the supplier's SDS. Last updated 7 Oct 2026. Report an error

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