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Skin conditioning agents and actives

IC 261

Also known as ic261, 3-((2,4,6-trimethoxyphenyl)methylidenyl)indolin-2-one, 3-((2,4,6-trimethoxyphenyl)methylidene)-2,3-dihydro-1H-indol-2-one

CAS 186611-52-9Formula C18H17NO4Molar mass 311.34 g/mol
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IC 261 chemical structure, C18H17NO4, CAS 186611-52-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
186611-52-9
Formula
C18H17NO4
Molar mass
311.34 g/mol
HS code
293379
Category
Skin conditioning agents and actives

What is IC 261?

Plain description, key identifiers and synonyms

IC 261 is a chemical substance with the molecular formula C18H17NO4 and a molar mass of 311.34 g/mol. Its CAS registry number is 186611-52-9. The IUPAC name is (3E)-3-[(2,4,6-trimethoxyphenyl)methylidene]-1H-indol-2-one.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3E)-3-[(2,4,6-trimethoxyphenyl)methylidene]-1H-indol-2-one
CAS number
186611-52-9
Molecular formula
C18H17NO4
MDL number
MFCD00118156
INCI name
3-(2,4,6-TRIMETHOXYBENZYLIDENE)-INDOLIN-2-ONE
InChIKey
JBJYTZXCZDNOJW-JLHYYAGUSA-N
InChI
InChI=1S/C18H17NO4/c1-21-11-8-16(22-2)14(17(9-11)23-3)10-13-12-6-4-5-7-15(12)19-18(13)20/h4-10H,1-3H3,(H,19,20)/b13-10+
Canonical SMILES
COc1cc(OC)c(C=C2C(=O)Nc3ccccc32)c(OC)c1
Isomeric SMILES
COC1=CC(=C(C(=C1)OC)/C=C/2\C3=CC=CC=C3NC2=O)OC

Synonyms

  • ic261
  • 3-((2,4,6-trimethoxyphenyl)methylidenyl)indolin-2-one
  • 3-((2,4,6-trimethoxyphenyl)methylidene)-2,3-dihydro-1H-indol-2-one
  • 3-[(2,4,6-Trimethoxy-phenyl)-methylene]-indolin-2-one
  • (3E)-3-[(2,4,6-trimethoxyphenyl)methylidene]-1H-indol-2-one
  • 3-[(2,4,6-Trimethoxyphenyl)methylidenyl]-indolin-2-one
  • 3-(2,4,6-trimethoxybenzylidene)indolin-2-one
  • 3-(2,4,6-Ttrimethoxybenzylidene)indolin-2-one
  • 1,3-Dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one
  • (E)-3-(2,4,6-trimethoxybenzylidene)indolin-2-one
  • (3E)-3-[(2,4,6-trimethoxyphenyl)methylene]indolin-2-one
  • HSCI1_000024
  • Sdccgsbi-0050990.p003
  • Sdccgsbi-0050990.p006
  • SU 5607
  • IC-261(SU-5607)?
  • (3E)-3-[(2,4,6-trimethoxyphenyl)methylidene]-1,3-dihydro-2H-indol-2-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
311.34 g/molcalc.
Exact mass
311.1158 Dacalc.
LogP (octanol/water)
3.21calc.
Topological polar surface area
56.79 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
23calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.17calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1Nc2ccccc2C1=Cc1ccccc1

O=C1Nc2ccccc2C1=Cc1ccccc1

3 rings, 17 atoms.

163 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

IC 261 suppliers

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IC 261 price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name 3-(2,4,6-TRIMETHOXYBENZYLIDENE)-INDOLIN-2-ONE(hair dyeing, skin protecting)

Cosmetic functions

  • Hair dyeing
  • Skin protecting

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code IC 261 is traded under.

HS 2933.79Indicative HS code

Lactams, other lactams

World exports in 2024
$16.2B
−64.4% vs 2023, imports $15.4B
2019 to 2024
Top exporters
  1. Ireland37.0%
  2. France * partner reported15.6%
  3. Spain11.3%
Top importers
  1. Germany27.8%
  2. Ireland18.9%
  3. Panama * partner reported12.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for IC 261 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about IC 261, based on the data on this page

What is IC 261?

IC 261 is a chemical substance with the molecular formula C18H17NO4 and a molar mass of 311.34 g/mol. Its CAS registry number is 186611-52-9. The IUPAC name is (3E)-3-[(2,4,6-trimethoxyphenyl)methylidene]-1H-indol-2-one.

What is the CAS number of IC 261?

The CAS registry number of IC 261 is 186611-52-9.

What is the molecular formula and weight of IC 261?

The molecular formula of IC 261 is C18H17NO4 and its molar mass is 311.34 g/mol.

What is IC 261 used for?

Known uses and roles of IC 261 include skin conditioning agents in cosmetics and personal care, colorants in cosmetics and personal care, hair dyeing and skin protecting.

Is IC 261 hazardous?

No GHS hazard classification for IC 261 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of IC 261?

IC 261 is usually classified under HS code 293379 (Lactams, other lactams). This is indicative, confirm it with your customs broker before shipping.

Where can I buy IC 261?

Post a free request on CompoundList and suppliers of IC 261 will send you quotes. Your contact details stay private until you accept a quote.

What is the price of IC 261?

Suppliers quote IC 261 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle IC 261

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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