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Murcko scaffold

Ring system with 3 rings and 17 atoms

164 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
164
With full pages
23
Scaffold SMILES

O=C1Nc2ccccc2C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1Nc2ccccc2C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 164 chemicals

3-(4-Dimethylaminobenzylidenyl)-2-indolinone chemical structure, C17H16N2O, CAS 5812-07-7
3-(4-Dimethylaminobenzylidenyl)-2-indolinone
CAS 5812-07-7C17H16N2O
3-[(4-Chlorophenyl)methylidene]-6-(trifluoromethyl)-1H-indol-2-one chemical structure, C16H9ClF3NO
3-[(4-Chlorophenyl)methylidene]-6-(trifluoromethyl)-1H-indol-2-one
C16H9ClF3NO
3-(O-Hydroxybenzylidene)-2-ketoindoline chemical structure, C15H11NO2
3-(O-Hydroxybenzylidene)-2-ketoindoline
C15H11NO2
3-(2,5-Dimethoxybenzylidene)-2-indolinone chemical structure, C17H15NO3, CAS 128943-02-2
3-(2,5-Dimethoxybenzylidene)-2-indolinone
CAS 128943-02-2C17H15NO3
3-{[4-(Trifluoromethyl)phenyl]methylidene}-1,3-dihydro-2H-indol-2-one chemical structure, C16H10F3NO, CAS 35315-56-1
3-{[4-(Trifluoromethyl)phenyl]methylidene}-1,3-dihydro-2H-indol-2-one
CAS 35315-56-1C16H10F3NO
3-(2-Methoxy-benzylidene)-3H-indol-2-ol chemical structure, C16H13NO2, CAS 186611-04-1
3-(2-Methoxy-benzylidene)-3H-indol-2-ol
CAS 186611-04-1C16H13NO2
2H-Indol-2-one, 3-[(2,6-dichlorophenyl)methylene]-1,3-dihydro- chemical structure, C15H9Cl2NO, CAS 212554-46-6
2H-Indol-2-one, 3-[(2,6-dichlorophenyl)methylene]-1,3-dihydro-
CAS 212554-46-6C15H9Cl2NO
(3E)-3-[(2,4-Dimethoxyphenyl)methylidene]-1H-indol-2-one chemical structure, C17H15NO3, CAS 856435-40-0
(3E)-3-[(2,4-Dimethoxyphenyl)methylidene]-1H-indol-2-one
CAS 856435-40-0C17H15NO3
(3Z)-3-[(3,4-Dimethoxyphenyl)methylidene]-1H-indol-2-one chemical structure, C17H15NO3, CAS 881885-10-5
(3Z)-3-[(3,4-Dimethoxyphenyl)methylidene]-1H-indol-2-one
CAS 881885-10-5C17H15NO3
2H-Indol-2-one, 3-[(4-fluorophenyl)methylene]-1,3-dihydro-, (Z)- chemical structure, C15H10FNO, CAS 90828-17-4
2H-Indol-2-one, 3-[(4-fluorophenyl)methylene]-1,3-dihydro-, (Z)-
CAS 90828-17-4C15H10FNO
3-(4-Hydroxy-3-methoxybenzylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C16H13NO3, CAS 494857-72-6
3-(4-Hydroxy-3-methoxybenzylidene)-1,3-dihydro-2H-indol-2-one
CAS 494857-72-6C16H13NO3
(3Z)-3-[(4-Hydroxyphenyl)methylidene]-5,6-dimethoxy-1H-indol-2-one chemical structure, C17H15NO4
(3Z)-3-[(4-Hydroxyphenyl)methylidene]-5,6-dimethoxy-1H-indol-2-one
C17H15NO4
1,3-Dihydro-3-[(2-hydroxy-3-methoxyphenyl)methylene]-5,6-dimethoxy-2H-indol-2-one chemical structure, C18H17NO5, CAS 269730-06-5
1,3-Dihydro-3-[(2-hydroxy-3-methoxyphenyl)methylene]-5,6-dimethoxy-2H-indol-2-one
CAS 269730-06-5C18H17NO5
3-(4-Chlorobenzylidene)-6-(trifluoromethyl)indolin-2-one chemical structure, C16H9ClF3NO
3-(4-Chlorobenzylidene)-6-(trifluoromethyl)indolin-2-one
C16H9ClF3NO
3-[4-Chlorobenzal]-6-trifluoromethyloxindole chemical structure, C16H9ClF3NO, CAS 35315-58-3
3-[4-Chlorobenzal]-6-trifluoromethyloxindole
CAS 35315-58-3C16H9ClF3NO
(3Z)-3-[(4-Bromophenyl)methylidene]-1H-indol-2-one chemical structure, C15H10BrNO, CAS 76086-99-2
(3Z)-3-[(4-Bromophenyl)methylidene]-1H-indol-2-one
CAS 76086-99-2C15H10BrNO
3-(4-Bromobenzylidene)indolin-2-one chemical structure, C15H10BrNO
3-(4-Bromobenzylidene)indolin-2-one
C15H10BrNO
3-(3-Methoxybenzylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C16H13NO2, CAS 391613-87-9
3-(3-Methoxybenzylidene)-1,3-dihydro-2H-indol-2-one
CAS 391613-87-9C16H13NO2
3-[(3,4-Dimethoxyphenyl)methylene]-1,3-dihydro-1-methyl-2H-indol-2-one chemical structure, C18H17NO3, CAS 3335-87-3
3-[(3,4-Dimethoxyphenyl)methylene]-1,3-dihydro-1-methyl-2H-indol-2-one
CAS 3335-87-3C18H17NO3
(3Z)-3-[(2,3-Dibromo-4,5-dimethoxyphenyl)methylidene]-1H-indol-2-one chemical structure, C17H13Br2NO3, CAS 445286-84-0
(3Z)-3-[(2,3-Dibromo-4,5-dimethoxyphenyl)methylidene]-1H-indol-2-one
CAS 445286-84-0C17H13Br2NO3
5-Bromo-3-(2,3-dimethoxybenzylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C17H14BrNO3, CAS 486443-96-3
5-Bromo-3-(2,3-dimethoxybenzylidene)-1,3-dihydro-2H-indol-2-one
CAS 486443-96-3C17H14BrNO3
(3Z)-5-Bromo-3-[(3-ethoxy-2-hydroxyphenyl)methylidene]-1H-indol-2-one chemical structure, C17H14BrNO3, CAS 486444-01-3
(3Z)-5-Bromo-3-[(3-ethoxy-2-hydroxyphenyl)methylidene]-1H-indol-2-one
CAS 486444-01-3C17H14BrNO3
3-[(3,5-Dibromo-4-hydroxyphenyl)methylidene]-1H-indol-2-one chemical structure, C15H9Br2NO2, CAS 265098-02-0
3-[(3,5-Dibromo-4-hydroxyphenyl)methylidene]-1H-indol-2-one
CAS 265098-02-0C15H9Br2NO2
N-(4-{[2-Oxo-6-(trifluoromethyl)-1,2-dihydro-3H-indol-3-yliden]methyl}phenyl)acetamide chemical structure, C18H13F3N2O2, CAS 860651-11-2
N-(4-{[2-Oxo-6-(trifluoromethyl)-1,2-dihydro-3H-indol-3-yliden]methyl}phenyl)acetamide
CAS 860651-11-2C18H13F3N2O2