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Oncology and immunology drugs

Inavolisib

Also known as Itovebi, (2S)-2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide, (2S)-2-[[2-[(4S)-4-(Difluoromethyl)-2-oxo-3-oxazolidinyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide

CAS 2060571-02-8Formula C18H19F2N5O4Molar mass 407.38 g/mol
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Inavolisib chemical structure, C18H19F2N5O4, CAS 2060571-02-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2060571-02-8
Formula
C18H19F2N5O4
Molar mass
407.38 g/mol
HS code
293499
Category
Oncology and immunology drugs

What is Inavolisib?

Plain description, key identifiers and synonyms

Inavolisib is an orally available inhibitor of phosphatidylinositol 3-kinase (PI3K), with potential antineoplastic activity. Upon administration, inavolisib binds to and inhibits various members of the PI3K family, including activating mutations in the catalytic alpha isoform PIK3CA. PI3K inhibition prevents the activation of the PI3K-mediated signaling pathway and results in the inhibition of growth and survival of PI3K-overexpressing tumor cells. Dysregulation of the PI3K signaling pathway is frequently associated with tumorigenesis and tumor resistance to a variety of antineoplastic agents and radiotherapy. PIK3CA, which encodes the p110-alpha catalytic subunit of the class I PI3K, is frequently mutated in a variety of cancer cell types and plays a key role in cancer cell growth and invasion.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide
CAS number
2060571-02-8
Molecular formula
C18H19F2N5O4
UNII
L4C1UY2NYH
MDL number
MFCD31382124
InChIKey
SGEUNORSOZVTOL-CABZTGNLSA-N
InChI
InChI=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11)24)25-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26)/t9-,12-/m0/s1
Canonical SMILES
CC(Nc1ccc2c(c1)OCCn1cc(N3C(=O)OCC3C(F)F)nc1-2)C(N)=O
Isomeric SMILES
C[C@@H](C(=O)N)NC1=CC2=C(C=C1)C3=NC(=CN3CCO2)N4[C@@H](COC4=O)C(F)F

Synonyms

  • Itovebi
  • (2S)-2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide
  • (2S)-2-[[2-[(4S)-4-(Difluoromethyl)-2-oxo-3-oxazolidinyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide
  • Propanamide, 2-((2-((4S)-4-(difluoromethyl)-2-oxo-3-oxazolidinyl)-5,6-dihydroimidazo(1,2-d)(1,4)benzoxazepin-9-yl)amino)-, (2S)-
  • (2S)-2-((2-((4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl)-5,6-dihydroimidazo(1,2-d)(1,4)benzoxazepin-9-yl)amino)propanamide
  • (2S)-2-((2-((4S)-4-(Difluoromethyl)-2-oxo-3-oxazolidinyl)-5,6-dihydroimidazo(1,2-d)(1,4)benzoxazepin-9-yl)amino)propanamide
  • (2S)-2-({2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}amino)propanamide
  • GDC 0077
  • Propanamide, 2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-3-oxazolidinyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]-, (2S)-
  • RG 6114
  • PI3K Inhibitor GDC0077
  • RO 7113755
  • (2S)-2-((4-((4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl)-9-oxa-3,6-diazatricyclo(8.4.0.0^(2,6))tetradeca-1(14),2,4,10,12-pentaen-12-yl)amino)propanamide
  • (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide
  • (S)-2-[[2-[(S)-4-(Difluoromethyl)-2-oxo-3-oxazolidinyl]-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]amino]propanamide
  • N~2~-{(4S,11aP)-2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-L-alaninamide
  • O-Methyl Hydroxy
  • Itovebi (TN)
  • Inavolisib (USAN/INN)
  • GDC-0077?
  • US10112932, Compound 101
  • WHO 11204
  • GDC-0077, RG6114
  • GDC-0077, RG6114, RO-7113755
  • (2S)-2-({4-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-9-oxa-3,6-diazatricyclo[8.4.0.0,tetradeca-1(14),2,4,10,12-pentaen-12-yl}amino)propanamide
Show all 28 synonyms
  • (2S)-2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide
  • (S)-2-((2-((S)-4-(difluoromethyl)- 2-oxooxazolidin-3-yl)-5,6- dihydrobenzo[f]imidazo[1,2- d][1,4]oxazepin-9- yl)amino)propanamide
  • (S)-2-((2-((S)-4-(Difluoromethyl)-2-oxooxaZolidin-3-yl)-5,6-dihydrobenZo[f]imidaZo[1,2-d][1,4]oxaZepin-9-yl)propanamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
407.38 g/molcalc.
Exact mass
407.1405 Dacalc.
LogP (octanol/water)
1.82calc.
Topological polar surface area
111.7 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
5calc.
Heavy atoms
29calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.39calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1OCCN1c1cn2c(n1)-c1ccccc1OCC2

O=C1OCCN1c1cn2c(n1)-c1ccccc1OCC2

4 rings, 20 atoms.

5 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Inavolisib suppliers

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Where suppliers are based

5 suppliers in 2 countries

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Inavolisib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Antineoplastic Agents
  • Phosphoinositide-3 Kinase Inhibitors

Roles

  • antineoplastic agent
  • pharmaceutical

Pharmacology

Inavolisib is a Kinase Inhibitor. The mechanism of action of inavolisib is as a Phosphoinositide 3-Kinase alpha Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Inavolisib is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Inavolisib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Inavolisib, based on the data on this page

What is Inavolisib?

Inavolisib is an orally available inhibitor of phosphatidylinositol 3-kinase (PI3K), with potential antineoplastic activity. Upon administration, inavolisib binds to and inhibits various members of the PI3K family, including activating mutations in the catalytic alpha isoform PIK3CA.

What is the CAS number of Inavolisib?

The CAS registry number of Inavolisib is 2060571-02-8.

What is the molecular formula and weight of Inavolisib?

The molecular formula of Inavolisib is C18H19F2N5O4 and its molar mass is 407.38 g/mol.

What is Inavolisib used for?

Known uses and roles of Inavolisib include anticancer drugs in pharmaceuticals, antineoplastic agent, pharmaceutical, antineoplastic agents and phosphoinositide-3 kinase inhibitors.

Is Inavolisib hazardous?

No GHS hazard classification for Inavolisib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Inavolisib?

Inavolisib is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Inavolisib?

CompoundList lists 5 suppliers of Inavolisib in United States and China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Inavolisib?

Suppliers quote Inavolisib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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