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Emollients

Itaconic acid

Also known as 2-Methylenesuccinic acid, 2-methylidenebutanedioic acid, Methylenesuccinic acid

CAS 97-65-4Formula C5H6O4Molar mass 130.10 g/molEC 202-599-6
GHS signal word: Danger. Pictograms: Corrosive, Harmful or irritant 108 suppliers listed
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Itaconic acid chemical structure, C5H6O4, CAS 97-65-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Rhombic crystals from benzene
Melting point
162 to 164
Boiling point
268 °C
Density
1.632
Solubility
1 G DISSOLVES IN 12 ML WATER, 5 ML ALC, VERY SLIGHTLY SOL IN BENZENE, CHLOROFORM, CARBON…
HS code
291719
Category
Emollients
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Itaconic acid?

Plain description, key identifiers and synonyms

Itaconic acid is a dicarboxylic acid that is methacrylic acid in which one of the methyl hydrogens is substituted by a carboxylic acid group. It has a role as a fungal metabolite and a human metabolite. It is a dicarboxylic fatty acid, a dicarboxylic acid and an olefinic compound. It is functionally related to a succinic acid. It is a conjugate acid of an itaconate(2-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-methylidenebutanedioic acid
CAS number
97-65-4 CAS number cross-checkedOther or deprecated CAS: 25119-64-6
EC number
202-599-6
Molecular formula
C5H6O4
UNII
Q4516562YH
MDL number
MFCD00004260
INCI name
ITACONIC ACID
InChIKey
LVHBHZANLOWSRM-UHFFFAOYSA-N
InChI
InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)
SMILES (canonical and isomeric)
C=C(CC(=O)O)C(=O)O

Synonyms

  • 2-Methylenesuccinic acid
  • 2-methylidenebutanedioic acid
  • Methylenesuccinic acid
  • Methylenebutanedioic acid
  • Propylenedicarboxylic acid
  • itaconate
  • Butanedioic acid, methylene-
  • 2-Propene-1,2-dicarboxylic acid
  • Succinic acid, methylene-
  • 2-methylenebutanedioic acid
  • methylidenebutanedioate
  • hydron, 2-methylidenebutanedioate
  • Itaconicacid
  • butanedioic acid, 2-methylene-
  • 3-Carboxy-3-butenoic acid
  • 2-methylenebutanedioate
  • Methylenesuccinate
  • ITN
  • Methylenebutanedioate
  • 2-Methylenesuccinate
  • Propylenedicarboxylate
  • Itaconic acid (Standard)
  • Itaconic acid, >=99%
  • 2-Methylene-Succinic Acid
  • Probes1_000076
Show all 34 synonyms
  • Probes2_000247
  • 2-Methylenesuccinic acid #
  • 2-methylene-butanedioic acid
  • 2-Propene-1,2-dicarboxylate
  • Itaconic acid, analytical standard
  • Succinic acid, methylene- (8CI)
  • 2-Hydroxy-3-Naphthoyl-2-Naphthylamine
  • Itaconic acid Solution in Water, 1000ug/mL
  • 2-Methylene,1,4-butanedioic acid (itaconic acid)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Rhombic crystals from benzeneexp.
Odour
CHARACTERISTIC ODORexp.
Melting point
162 to 164exp.
Boiling point
268 °Cexp.
Density
1.632exp.
Solubility
1 G DISSOLVES IN 12 ML WATER, 5 ML ALC, VERY SLIGHTLY SOL IN BENZENE, CHLOROFORM, CARBON DISULFIDE, PETROLEUM ETHERexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
130.10 g/molcalc.
Exact mass
130.0266 Dacalc.
LogP (octanol/water)
0.1calc.
Topological polar surface area
74.6 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
9calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.2calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H318Causes serious eye damage.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (18)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Itaconic acid suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 108 suppliers
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Where suppliers are based

108 suppliers in 19 countries

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Itaconic acid price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Copolymerizations, resins, plasticizers, lube oil additives, intermediate.

Industrial uses: Surface modifier, Intermediate, Monomers.

Cosmetic ingredient, INCI name ITACONIC ACID(antimicrobial, buffering, skin conditioning - emollient, skin conditioning)

Roles

  • animal metabolite
  • eukaryotic metabolite
  • fungal metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite

Functional uses

  • Biocide
  • Softener and conditioner
  • pH regulating agent

Cosmetic functions

  • Antimicrobial
  • Buffering
  • Skin conditioning
  • Skin conditioning - emollient

How it is made

Obtained by dry distillation of citric acid and subsequent treatment of the anhydride with water. Produced on a large scale by submerged aerobic fermentation using aspergillus terreus and low cost carbohydrates from beet or cane: kane et al, us patent 2,385,283 (1945 to pfizer).

Synthesis from propargyl chloride, carbon monoxide, nickel carbonyl & water: chiusoli, us patent 3,025,320 (1962 to montecatini).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Itaconic acid is traded under.

HS 2917.19Indicative HS code

Acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and…

World exports in 2024
$718M
+8.1% vs 2023, imports $915M
2019 to 2024
Top exporters
  1. China46.6%
  2. United States13.7%
  3. Germany10.1%
Top importers
  1. United States16.2%
  2. Denmark11.8%
  3. Germany10.0%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Itaconic acid is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Itaconic acid, based on the data on this page

What is Itaconic acid?

Itaconic acid is a dicarboxylic acid that is methacrylic acid in which one of the methyl hydrogens is substituted by a carboxylic acid group. It has a role as a fungal metabolite and a human metabolite. It is a dicarboxylic fatty acid, a dicarboxylic acid and an olefinic compound.

What is the CAS number of Itaconic acid?

The CAS registry number of Itaconic acid is 97-65-4. Other or deprecated CAS numbers: 25119-64-6.

What is the molecular formula and weight of Itaconic acid?

The molecular formula of Itaconic acid is C5H6O4 and its molar mass is 130.10 g/mol.

What is Itaconic acid used for?

Copolymerizations, resins, plasticizers, lube oil additives, intermediate. Industrial uses: Surface modifier, Intermediate, Monomers.

Is Itaconic acid hazardous?

Itaconic acid carries the GHS signal word "Danger". Main hazards: causes skin irritation, causes serious eye damage, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Itaconic acid?

Itaconic acid is usually classified under HS code 291719 (Acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Itaconic acid?

CompoundList lists 108 suppliers of Itaconic acid in China, United States, India, Germany and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Itaconic acid in India?

11 suppliers in India list Itaconic acid on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Itaconic acid?

Suppliers quote Itaconic acid on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Itaconic acid

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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