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Amino acids and derivatives

L-Hydroxyproline

Also known as trans-4-Hydroxy-L-proline, hydroxyproline, Hypro

CAS 51-35-4Formula C5H9NO3Molar mass 131.13 g/molEC 200-091-9
GHS signal word: Warning. Pictograms: Harmful or irritant 85 suppliers listed Drug substance
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L-Hydroxyproline chemical structure, C5H9NO3, CAS 51-35-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
51-35-4
Formula
C5H9NO3
Molar mass
131.13 g/mol
EC number
200-091-9
HS code
293399
Category
Amino acids and derivatives

What is L-Hydroxyproline?

Plain description, key identifiers and synonyms

Trans-4-hydroxy-L-proline is an optically active form of 4-hydroxyproline having L-trans-configuration. It has a role as a mouse metabolite, a plant metabolite and a human metabolite. It is a tautomer of a trans-4-hydroxy-L-proline zwitterion.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid
CAS number
51-35-4 CAS number cross-checkedOther or deprecated CAS: 147028-80-6, 618-28-0
EC number
200-091-9
Molecular formula
C5H9NO3
UNII
RMB44WO89X
MDL number
MFCD00064320
INCI name
HYDROXYPROLINE
InChIKey
PMMYEEVYMWASQN-DMTCNVIQSA-N
InChI
InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
Canonical SMILES
O=C(O)C1CC(O)CN1
Isomeric SMILES
C1[C@H](CN[C@@H]1C(=O)O)O

Synonyms

  • trans-4-Hydroxy-L-proline
  • hydroxyproline
  • Hypro
  • hydroxy-L-proline
  • (4R)-4-hydroxy-L-proline
  • trans-L-Hydroxyproline
  • L-Proline, 4-hydroxy-, (4R)-
  • trans-Hydroxyproline
  • 4-Hydroxy-2-pyrrolidinecarboxylic acid
  • delta-Hydroxyproline
  • L-Proline, 4-hydroxy-, trans-
  • (2S,4R)-4-hydroxyproline
  • Lumistor
  • L-threo-4-hydroxyproline
  • (2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid
  • [2S,4r]-4-Hydroxy-2-pyrrolidinecarboxylic acid
  • oxyproline
  • (2S,4R)-4-hydroxypyrrolidin-1-ium-2-carboxylate
  • NMH-Pro
  • cis 4 Hydroxyproline
  • 4 Hydroxyproline
  • O Hui Wrinkle Science Wrinkle Repair
  • Ohui Wrinkle Science Wrinkle Repair Eye
  • (2S,4R)-4-hydroxypyrrolidinium-2-carboxylate
  • (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
Show all 38 synonyms
  • L-4-hydroxyproline
  • H-Hyp-OH
  • trans-4-Hydroxyproline
  • 4-Hydroxy-L-proline
  • Hydroxyproline (VAN)
  • Proline, 4-hydroxy-, L-
  • 4-L-Hydroxyproline
  • Proline, 4-hydroxy- (VAN)
  • L-Proline, 4-hydroxy-
  • Proline, 4-hydroxy-
  • (2S,4R)-trans-4-hydroxyproline
  • (2S,4R)-rel-4-Hydroxypyrrolidine-2-carboxylic acid
  • Hyp

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
131.13 g/molcalc.
Exact mass
131.0582 Dacalc.
LogP (octanol/water)
-1.21calc.
Topological polar surface area
69.56 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
9calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.8calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CCNC1

C1CCNC1

1 ring, 5 atoms, the Pyrrolidine ring system.

22,348 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

L-Hydroxyproline suppliers

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All 85 suppliers
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Where suppliers are based

85 suppliers in 13 countries

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L-Hydroxyproline price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Cosmetics.

Cosmetic ingredient, INCI name HYDROXYPROLINE(antistatic, hair conditioning, skin conditioning, surfactant - cleansing)

Roles

  • animal metabolite
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • mouse metabolite
  • plant metabolite

Functional uses

  • Anti-static agent
  • Softener and conditioner
  • Surfactant (surface active agent)

Cosmetic functions

  • Antistatic
  • Hair conditioning
  • Skin conditioning
  • Surfactant - cleansing

Pharmacology

Hydroxyproline is a nonessential amino acid derivative formed during post-translational protein modification through hydroxylation of the amino acid proline by the enzyme prolyl hydroxylase which requires vitamin C as a co-factor. Hydroxyproline is a major component of the protein collagen and plays a key role in the stability of the collagen triple helix. It can be used as an indicator to determine the amount of collagen. Increased hydroxyproline levels in the urine and/or serum are normally associated with degradation of connective tissue. Vitamin C deficiency decreases the conversion of proline to hydroxyproline, which leads to reduced collagen stability.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code L-Hydroxyproline is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for L-Hydroxyproline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about L-Hydroxyproline, based on the data on this page

What is L-Hydroxyproline?

Trans-4-hydroxy-L-proline is an optically active form of 4-hydroxyproline having L-trans-configuration. It has a role as a mouse metabolite, a plant metabolite and a human metabolite. It is a tautomer of a trans-4-hydroxy-L-proline zwitterion.

What is the CAS number of L-Hydroxyproline?

The CAS registry number of L-Hydroxyproline is 51-35-4. Other or deprecated CAS numbers: 147028-80-6, 618-28-0.

What is the molecular formula and weight of L-Hydroxyproline?

The molecular formula of L-Hydroxyproline is C5H9NO3 and its molar mass is 131.13 g/mol.

What is L-Hydroxyproline used for?

Use classes: Cosmetics.

Is L-Hydroxyproline hazardous?

L-Hydroxyproline carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of L-Hydroxyproline?

L-Hydroxyproline is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy L-Hydroxyproline?

CompoundList lists 85 suppliers of L-Hydroxyproline in China, United States, Germany, India and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy L-Hydroxyproline in India?

4 suppliers in India list L-Hydroxyproline on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of L-Hydroxyproline?

Suppliers quote L-Hydroxyproline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle L-Hydroxyproline

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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