CompoundList
Sign in
Amino acids and derivatives

4-Hydroxyproline

Also known as 4-hydroxypyrrolidine-2-carboxylic acid, trans-L-4-hydroxyproline, 4-Hydroxy-DL-proline

CAS 6912-67-0Formula C5H9NO3Molar mass 131.13 g/mol
52 suppliers listed
Get quotes Compare 52 suppliers
4-Hydroxyproline chemical structure, C5H9NO3, CAS 6912-67-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
6912-67-0
Formula
C5H9NO3
Molar mass
131.13 g/mol
HS code
293399
Category
Amino acids and derivatives

What is 4-Hydroxyproline?

Plain description, key identifiers and synonyms

4-hydroxyproline is a monohydroxyproline where the hydroxy group is located at the 4-position. It is found in fibrillar collagen. It has a role as a human metabolite. It is a conjugate acid of a 4-hydroxyprolinate. It is a tautomer of a 4-hydroxyproline zwitterion.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-hydroxypyrrolidine-2-carboxylic acid
CAS number
6912-67-0 CAS number cross-checkedOther or deprecated CAS: 147028-80-6, 18610-59-8, 25249-07-4, 2584-71-6, 30724-02-8, 3398-22-9, 49761-17-3, 618-27-9
Molecular formula
C5H9NO3
MDL number
MFCD00066718
InChIKey
PMMYEEVYMWASQN-UHFFFAOYSA-N
InChI
InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)
SMILES (canonical and isomeric)
C1C(CNC1C(=O)O)O

Synonyms

  • 4-hydroxypyrrolidine-2-carboxylic acid
  • trans-L-4-hydroxyproline
  • 4-Hydroxy-DL-proline
  • L-Allohydroxyproline
  • L-Proline, 4-hydroxy-, labeled with tritium, trans-
  • 4-Hydroxy-L-proline
  • Proline, 4-hydroxy-
  • L-Trans-4-hydroxy-L-proline
  • d-hydroxyproline
  • D-cis-Hydroxyproline
  • allo-L-Hydroxyproline
  • L -4-Hydroxy-2-pyrrolidine-carboxylic acid
  • Hypdroxyproline
  • L-Hydroxyprolin
  • D-Proline, cis-
  • L-Proline, cis-
  • 4Hyp
  • 4-Hydroxyproline #
  • (2S)-4-hydroxy-2-pyrrolidinecarboxylic acid
  • D-trans-Hydroxyproline
  • BB 0219895
  • Cis -4-hydroxy-L-proline
  • Trans- 4-hydroxy -D-proline
  • cis-d-4-Hydroxyproline
  • Pyrrolidin-4-ol-2-carboxylic acid
Show all 32 synonyms
  • 4-hydroxypyrrolidine-2-carboxylicacid
  • 4-hydroxy-pyrrolidine-2-carboxylic acid
  • 2-Pyrrolidinecarboxylic acid, 4-hydroxy-
  • trans-L-4-Hydroxyproline, Non-animal origin
  • 4-Hydroxypyrrolidine-2-carboxylic acid, AldrichCPR
  • (25,45)-(-)-4-Hydroxy-2-pyrrolidine carboxylic acid
  • 2(1H)-quinolinone,5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dih

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
131.13 g/molcalc.
Exact mass
131.0582 Dacalc.
LogP (octanol/water)
-1.21calc.
Topological polar surface area
69.56 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
9calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.8calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CCNC1

C1CCNC1

1 ring, 5 atoms, the Pyrrolidine ring system.

22,348 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

4-Hydroxyproline suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 52 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

52 suppliers in 10 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

4-Hydroxyproline price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Roles

  • animal metabolite
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite

Functional uses

  • Flavouring and nutrient

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 4-Hydroxyproline is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 4-Hydroxyproline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 4-Hydroxyproline, based on the data on this page

What is 4-Hydroxyproline?

4-hydroxyproline is a monohydroxyproline where the hydroxy group is located at the 4-position. It is found in fibrillar collagen. It has a role as a human metabolite. It is a conjugate acid of a 4-hydroxyprolinate. It is a tautomer of a 4-hydroxyproline zwitterion.

What is the CAS number of 4-Hydroxyproline?

The CAS registry number of 4-Hydroxyproline is 6912-67-0. Other or deprecated CAS numbers: 147028-80-6, 18610-59-8, 25249-07-4.

What is the molecular formula and weight of 4-Hydroxyproline?

The molecular formula of 4-Hydroxyproline is C5H9NO3 and its molar mass is 131.13 g/mol.

What is 4-Hydroxyproline used for?

Known uses and roles of 4-Hydroxyproline include animal metabolite, eukaryotic metabolite, human metabolite, mammalian metabolite, metabolite and 1 more.

Is 4-Hydroxyproline hazardous?

No GHS hazard classification for 4-Hydroxyproline is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of 4-Hydroxyproline?

4-Hydroxyproline is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 4-Hydroxyproline?

CompoundList lists 52 suppliers of 4-Hydroxyproline in United States, China, United Kingdom, Hong Kong and 6 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of 4-Hydroxyproline?

Suppliers quote 4-Hydroxyproline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 4-Hydroxyproline

Get quotes for 4-Hydroxyproline

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell 4-Hydroxyproline
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of 4-Hydroxyproline with a 3D view, its CAS number and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/4-hydroxyproline-6912-67-0" title="4-Hydroxyproline structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Amino acids and derivatives or HS code 293399

52 suppliers
Free quotes, contact stays private
Get quotes