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Amino acids and derivatives

Leukotriene E4

Also known as Leukotriene E, 5S-hydroxy,6R-(S-cysteinyl),7E,9E,11Z,14Z-eicosatetraenoic acid, (5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid

CAS 75715-89-8Formula C23H37NO5SMolar mass 439.62 g/mol
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Leukotriene E4 chemical structure, C23H37NO5S, CAS 75715-89-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
75715-89-8
Formula
C23H37NO5S
Molar mass
439.62 g/mol
HS code
293090
Category
Amino acids and derivatives

What is Leukotriene E4?

Plain description, key identifiers and synonyms

Leukotriene E4 is a leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and an L-cystein-S-yl group at position 6 (6R). It is a leukotriene, a L-cysteine thioether, a secondary alcohol, an amino dicarboxylic acid and a non-proteinogenic L-alpha-amino acid. It is functionally related to an icosa-7,9,11,14-tetraenoic acid. It is a conjugate acid of a leukotriene E4(1-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
CAS number
75715-89-8 CAS number cross-checked
Molecular formula
C23H37NO5S
UNII
8EYT8ATL7G
InChIKey
OTZRAYGBFWZKMX-FRFVZSDQSA-N
InChI
InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1
Canonical SMILES
CCCCCC=CCC=CC=CC=CC(SCC(N)C(=O)O)C(O)CCCC(=O)O
Isomeric SMILES
CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N

Synonyms

  • Leukotriene E
  • 5S-hydroxy,6R-(S-cysteinyl),7E,9E,11Z,14Z-eicosatetraenoic acid
  • (5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
  • (7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyeicosa-7,9,11,14-tetraenoate
  • (7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate
  • (5S-(5R*,6S*(S*),7E,9E,11Z,14Z))-6-((2-Amino-2-carboxyethyl)thio)-5-hydroxy-7,9,11,14-eicosatetraenoic acid
  • 7,9,11,14-Eicosatetraenoic acid, 6-((2-amino-2-carboxyethyl)thio)-5-hydroxy-, (5S-(5R*,6S*(S*),7E,9E,11Z,14Z))-
  • Leukotriene E 4
  • Leukotriene E-4
  • (5S,6R,7E,9E,11Z,14Z)-6-(2-Amino-2-carboxyethyl)sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
  • (5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
  • (5S,6R,7E,9E,11Z,14Z)-6-((2R)-2-amino-2-carboxyethyl)sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
  • (5S,6R,7E,9E,11Z,14Z)-6-((2R)-2-amino-3-hydroxy-3-oxopropyl)sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
  • S-((1R,2E,4E,6Z,9Z)-1-((1S)-4-carboxy-1-hydroxybutyl)pentadeca-2,4,6,9-tetraen-1-yl)-L-cysteine
  • S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteine
  • Leukotriene E(4)
  • (5S,6R,7E,9E,11Z,14Z)-6-((2-amino-2-carboxyethyl)sulfanyl)-5-hydroxyicosa-7,9,11,14-tetraenoic acid
  • (5S,6R,7E,9E,11Z,14Z)-6-(((R)-2-Amino-2-carboxyethyl)thio)-5-hydroxyicosa-7,9,11,14-tetraenoic acid
  • 7,9,11,14-Eicosatetraenoicacid, 6-[[(2R)-2-amino-2-carboxyethyl]thio]-5-hydroxy-, (5S,6R,7E,9E,11Z,14Z)-
  • Leukotrienee4
  • [3H]LTE4
  • 5S-Hydroxy-6R-(S-cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid
  • Leukotrien e4
  • (5S,6R,7E,9E,11Z,14Z)-6-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-5-hydroxyicosa-7,9,11,14-tetraenoic acid
  • Leukotriene E4 Lipid Maps(R) MS Standard
Show all 29 synonyms
  • 5S-hydroxy-6R-(S-cysteinyl),7E,9E,11Z,14Z-eicosatetraenoic acid
  • (5S,6R,7E,9E,11Z,14Z)-6-(L-cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoic acid
  • [5S-[5R*,6S*(S*),7E,9E,11Z,14Z]]- 6-[(2-amino-2-carboxyethyl)thio]-5-hydroxy-7,9,11,14-Eicosatetraenoate
  • [5S-[5R*,6S*(S*),7E,9E,11Z,14Z]]- 6-[(2-amino-2-carboxyethyl)thio]-5-hydroxy-7,9,11,14-Eicosatetraenoic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
439.62 g/molcalc.
Exact mass
439.2392 Dacalc.
LogP (octanol/water)
4.31calc.
Topological polar surface area
120.9 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
18calc.
Heavy atoms
30calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.57calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Leukotriene E4 suppliers

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Leukotriene E4 price

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Uses and applications

What the substance is used for, by industry and function

Roles

  • animal metabolite
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite

Pharmacology

Leukotriene E4 is the final and most stable product of the pathway where 5-lipoxygenase converts arachidonic acid to cysteinyl leukotrienes, with inflammatory activity. Because of its inherent stability, leukotriene E4 is used as a marker for leukotriene production.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Leukotriene E4 is traded under.

HS 2930.90Indicative HS code

Organo-sulphur compounds, other

World exports in 2024
$5.83B
+0.1% vs 2023, imports $5.93B
2019 to 2024
Top exporters
  1. China40.7%
  2. United States10.9%
  3. Japan9.3%
Top importers
  1. United States13.3%
  2. Brazil12.6%
  3. China6.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Leukotriene E4 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Leukotriene E4, based on the data on this page

What is Leukotriene E4?

Leukotriene E4 is a leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and an L-cystein-S-yl group at position 6 (6R).

What is the CAS number of Leukotriene E4?

The CAS registry number of Leukotriene E4 is 75715-89-8.

What is the molecular formula and weight of Leukotriene E4?

The molecular formula of Leukotriene E4 is C23H37NO5S and its molar mass is 439.62 g/mol.

What is Leukotriene E4 used for?

Known uses and roles of Leukotriene E4 include animal metabolite, eukaryotic metabolite, human metabolite, mammalian metabolite and metabolite.

Is Leukotriene E4 hazardous?

No GHS hazard classification for Leukotriene E4 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Leukotriene E4?

Leukotriene E4 is usually classified under HS code 293090 (Organo-sulphur compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Leukotriene E4?

CompoundList lists 1 supplier of Leukotriene E4 in United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Leukotriene E4?

Suppliers quote Leukotriene E4 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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