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Central nervous system drugs

Levodopa

Also known as L-dopa, 3,4-dihydroxy-L-phenylalanine, Dopar

CAS 59-92-7Formula C9H11NO4Molar mass 197.19 g/molEC 200-445-2
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard, Hazardous to the environment 129 suppliers listed Drug substance
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Levodopa chemical structure, C9H11NO4, CAS 59-92-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless to white crystals or crystalline powder, needles from water
Melting point
284 to 286
Solubility
In water, 5,000 mg/l @ 20 °C
HS code
292250
Category
Central nervous system drugs
Illustrative photo, off-white crystalline powder in fibre drums in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Levodopa?

Plain description, key identifiers and synonyms

L-dopa is an optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. It has a role as a plant growth retardant, an antiparkinson drug, a dopaminergic agent, a prodrug, a neurotoxin, a hapten, an allelochemical, an antidyskinesia agent, a mouse metabolite, a plant metabolite and a human metabolite. It is a L-tyrosine derivative, a dopa and a non-proteinogenic L-alpha-amino acid. It is a conjugate acid of a L-dopa(1-). It is an enantiomer of a D-dopa. It is a tautomer of a L-dopa zwitterion.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
CAS number
59-92-7 CAS number cross-checkedOther or deprecated CAS: 122769-74-8, 65170-01-6
EC number
200-445-2
Molecular formula
C9H11NO4
UNII
46627O600J
MDL number
MFCD00002598
InChIKey
WTDRDQBEARUVNC-LURJTMIESA-N
InChI
InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
Canonical SMILES
NC(Cc1ccc(O)c(O)c1)C(=O)O
Isomeric SMILES
C1=CC(=C(C=C1C[C@@H](C(=O)O)N)O)O

Synonyms

  • L-dopa
  • 3,4-dihydroxy-L-phenylalanine
  • Dopar
  • 3-Hydroxy-L-tyrosine
  • Larodopa
  • Bendopa
  • 3-(3,4-Dihydroxyphenyl)-L-alanine
  • Levopa
  • Brocadopa
  • Dopaidan
  • Dopalina
  • Dopasol
  • Eldopal
  • Insulamina
  • Pardopa
  • Cidandopa
  • Dopaflex
  • Maipedopa
  • Deadopa
  • Eldopar
  • Prodopa
  • Syndopa
  • Veldopa
  • (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
  • Helfo-Dopa
Show all 39 synonyms
  • (-)-Dopa
  • Doparkine
  • Dopastral
  • Dopaston
  • Doparl
  • Doprin
  • Dihydroxy-L-phenylalanine
  • L-3,4-Dihydroxyphenylalanine
  • Eldopatec
  • Eurodopa
  • Ledopa
  • L-o-Hydroxytyrosine
  • L-Tyrosine, 3-hydroxy-
  • Biodopa

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless to white crystals or crystalline powder, needles from waterexp.
Odour
Odorlessexp.
Taste
Tastelessexp.
Melting point
284 to 286exp.
Solubility
In water, 5,000 mg/l @ 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
197.19 g/molcalc.
Exact mass
197.0688 Dacalc.
LogP (octanol/water)
0.05calc.
Topological polar surface area
103.8 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
3calc.
Heavy atoms
14calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.22calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H361Suspected of damaging fertility or the unborn child.
  • H361dSuspected of damaging the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H411Toxic to aquatic life with long lasting effects.
  • H412Harmful to aquatic life with long lasting effects.
Precautionary statements (24)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Levodopa suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 129 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

129 suppliers in 16 countries

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Levodopa price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Antiparkinson Agents
  • Dopamine Agents

Roles

  • allelochemical
  • analgesic
  • anti-asthmatic agent
  • antidepressant
  • antidyskinesia agent
  • antiparkinson drug
  • antipsychotic agent
  • cardiovascular drug
  • central nervous system drug
  • dopaminergic agent
  • hapten
  • human metabolite
  • mouse metabolite
  • neuroprotective agent
  • neurotoxin
  • neurotransmitter agent
  • ophthalmology drug
  • pharmaceutical
  • plant growth retardant
  • plant metabolite
  • pro-agent
  • prodrug
  • protective agent
  • vasoconstrictor agent

Functional uses

  • Pharmaceutical

Pharmacology

Levodopa is an Aromatic Amino Acid.

How it is made

Derived from several types of beans including vanilla.

Preparation from L-tyrosine: Vorbruggen, Krolikiewicz, Ber. 105, 1168 (1972), Bretschneider et al., Helv. Chim. Acta 56, 2857 (1973), from Vicia faba beans: Wysong, US 3253023 (1966 to Dow Chem.), by fermentation of L-tyrosine: Sih et al., J. Am. Chem. Soc. 91, 6204 (1969), Florent, Renaut, DE 2102793 (1971 to Rhone-Poulenc), C.A. 75, 108505f (1971). Separation from racemate: Vogler, Baumgartner, Helv. Chim.

Read more

Acta 35, 1776 (1952), NL 6514950, US 3405159 (1966, 1968 both to Merck & Co.)

Production: glycine + acetic anhydride + vanillin (amide formation/carbonyl condensation/chiral catalytic hydrogenation/hydrolysis. Production: 2,4-dihydroxybenzaldehyde + hydrogen cyanide + ammonia (Strecker synthesis/racemate separation). Production: catechol + pyruvic acid + ammonia (microbial conversion)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Levodopa is traded under.

HS 2922.50Indicative HS code

Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function

World exports in 2024
$3.29B
−5.9% vs 2023, imports $3.19B
2019 to 2024
Top exporters
  1. China39.2%
  2. United Kingdom27.1%
  3. India * partner reported4.8%
Top importers
  1. United States20.7%
  2. Germany7.6%
  3. Italy6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Levodopa is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Levodopa, based on the data on this page

What is Levodopa?

L-dopa is an optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease.

What is the CAS number of Levodopa?

The CAS registry number of Levodopa is 59-92-7. Other or deprecated CAS numbers: 122769-74-8, 65170-01-6.

What is the molecular formula and weight of Levodopa?

The molecular formula of Levodopa is C9H11NO4 and its molar mass is 197.19 g/mol.

What is Levodopa used for?

Use classes: Pharmaceuticals.

Is Levodopa hazardous?

Levodopa carries the GHS signal word "Danger". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Levodopa?

Levodopa is usually classified under HS code 292250 (Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Levodopa?

CompoundList lists 129 suppliers of Levodopa in China, United States, India, Germany and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Levodopa in India?

8 suppliers in India list Levodopa on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Levodopa?

Suppliers quote Levodopa on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Levodopa

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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