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Screening compounds

Litronesib

Also known as KF 89617, LY 2523355, Propanamide, N-(4-(2,2-dimethyl-1-oxopropyl)-5-((((2-(ethylamino)ethyl)sulfonyl) amino)methyl)-4,5-dihydro-5-phenyl-1,3,4-thiadiazol-2-yl)-2,2-dimethyl-, (-)-

CAS 910634-41-2Formula C23H37N5O4S2Molar mass 511.71 g/mol
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Litronesib chemical structure, C23H37N5O4S2, CAS 910634-41-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
910634-41-2
Formula
C23H37N5O4S2
Molar mass
511.71 g/mol
HS code
293590
Category
Screening compounds

What is Litronesib?

Plain description, key identifiers and synonyms

Litronesib is an inhibitor of the kinesin-related motor protein Eg5 with potential antineoplastic activity. Litronesib selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and consequently cell death in tumor cells that are actively dividing. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein that plays an essential role during mitosis, particularly in the regulation of spindle dynamics, including assembly and maintenance.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[(5R)-4-(2,2-dimethylpropanoyl)-5-[[2-(ethylamino)ethylsulfonylamino]methyl]-5-phenyl-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide
CAS number
910634-41-2
Molecular formula
C23H37N5O4S2
UNII
6611F8KYCV
MDL number
MFCD19442197
InChIKey
YVAFBXLHPINSIK-QHCPKHFHSA-N
InChI
InChI=1S/C23H37N5O4S2/c1-8-24-14-15-34(31,32)25-16-23(17-12-10-9-11-13-17)28(19(30)22(5,6)7)27-20(33-23)26-18(29)21(2,3)4/h9-13,24-25H,8,14-16H2,1-7H3,(H,26,27,29)/t23-/m0/s1
Canonical SMILES
CCNCCS(=O)(=O)NCC1(c2ccccc2)SC(NC(=O)C(C)(C)C)=NN1C(=O)C(C)(C)C
Isomeric SMILES
CCNCCS(=O)(=O)NC[C@@]1(N(N=C(S1)NC(=O)C(C)(C)C)C(=O)C(C)(C)C)C2=CC=CC=C2

Synonyms

  • KF 89617
  • LY 2523355
  • Propanamide, N-(4-(2,2-dimethyl-1-oxopropyl)-5-((((2-(ethylamino)ethyl)sulfonyl) amino)methyl)-4,5-dihydro-5-phenyl-1,3,4-thiadiazol-2-yl)-2,2-dimethyl-, (-)-
  • litronesibum
  • (-)-N-(4-(2,2-dimethyl-propionyl)-5-((2-ethylamino-ethanesulfonylamino)-methyl)-5-phenyl-4,5-dihydro-(1,3,4)thiadiazol-2-yl)-2,2-dimethyl-propionamide
  • (-)-N-(4-(2,2-dimethylpropanoyl)-5-((((2-(ethylamino)ethyl)sulfonyl)amino)methyl)-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)-2,2-dimethylpropanamide
  • (R)-N-(4-(2,2-dimethyl-propionyl)-5-((2-ethylamino-ethanesulfonylamino)-methyl)-5-phenyl-4,5-dihydro-(1,3,4)thiadiazol-2-yl)-2,2-dimethyl-propionamide
  • N-((5R)-4-(2,2-dimethylpropanoyl)-5-((2-(ethylamino)ethanesulfonamido)methyl)-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)-2,2-dimethylpropanamide
  • N-(4-(2,2-dimethyl-propionyl)-5-((2-ethylamino-ethanesulfonylamino)-methyl)-5-phenyl-4,5-dihydro-(1,3,4)thiadiazol-2-yl)-2,2-dimethyl-propionamide
  • N-[(5R)-4-(2,2-dimethylpropanoyl)-5-[[2-(ethylamino)ethylsulfonylamino]methyl]-5-phenyl-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide
  • (-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide
  • (R)-N-(5-(((2-(Ethylamino)ethyl)sulfonamido)methyl)-5-phenyl-4-pivaloyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)pivalamide
  • (-)-N-(4-(2,2-Dimethylpropanoyl)-5-((((2-(ethylamino)ethyl)sulfonyl)amino)methyl)-5- phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)-2,2-dimethylpropanamide
  • (-)-N-{4-(2,2-dimethylpropanoyl)-5-(({(2-(ethylamino)ethyl)sulfonyl}amino)methyl)-5- phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl}-2,2-dimethylpropanamide
  • (5-hydroxy-6-m
  • Litronesib (USAN/INN)
  • (R)-N-(5-((2-(ethylamino)ethylsulfonamido)methyl)-5-phenyl-4-pivaloyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)pivalamide.
  • N-[(5R)-4-(2,2-dimethylpropanoyl)-5-[[2-(ethylamino)ethylsulfonylamino]methyl]-5-phenyl-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propanamide
  • (R)-N-(4-(2,2-Dimethyl-propionyl)-5-((2-ethylamino-ethanesulfonylamino)-methyl)-5- phenyl-4,5-dihydro-(1,3,4)thiadiazol-2-yl)-2,2-dimethyl-propionamide
  • (R)-N-{4-(2,2-dimethyl-propionyl)-5-((2-ethylamino-ethanesulfonylamino)-methyl)-5- phenyl-4,5-dihydro-(1,3,4)thiadiazol-2-yl}-2,2-dimethyl-propionamiden
  • N-(4-(2,2-Dimethylpropionyl)-(5R)-5-((2-ethylamino-ethanesulfonylamino)methyl)-5-phenyl-4,5-dihydro-(1,3,4)thiadiazol-2-yl)-2,2-dimethylpropionamide
  • Propanamide, N-(4-(2,2-dimethyl-1-oxopropyl)-5-((((2-(ethylamino)ethyl)sulfonyl)amino)methyl)-4,5-dihydro-5-phenyl-1,3,4-thiadiazol-2-yl)-2,2-dimethyl-, (5R)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
511.71 g/molcalc.
Exact mass
511.2287 Dacalc.
LogP (octanol/water)
2.42calc.
Topological polar surface area
120 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
8calc.
Heavy atoms
34calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.61calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=NNC(c2ccccc2)S1

C1=NNC(c2ccccc2)S1

2 rings, 11 atoms.

25 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Litronesib suppliers

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Litronesib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Litronesib is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Litronesib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Litronesib, based on the data on this page

What is Litronesib?

Litronesib is an inhibitor of the kinesin-related motor protein Eg5 with potential antineoplastic activity. Litronesib selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and consequently cell death in tumor cells that are actively dividing.

What is the CAS number of Litronesib?

The CAS registry number of Litronesib is 910634-41-2.

What is the molecular formula and weight of Litronesib?

The molecular formula of Litronesib is C23H37N5O4S2 and its molar mass is 511.71 g/mol.

What is Litronesib used for?

Known uses and roles of Litronesib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Litronesib hazardous?

No GHS hazard classification for Litronesib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Litronesib?

Litronesib is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Litronesib?

CompoundList lists 1 supplier of Litronesib in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Litronesib?

Suppliers quote Litronesib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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