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Central nervous system drugs

Lormetazepam

Also known as Methyllorazepam, N-Methyllorazepam, Loramet

CAS 848-75-9Formula C16H12Cl2N2O2Molar mass 335.19 g/molEC 212-700-5
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard Prohibited, not for trade
Why it is not for trade
Lormetazepam chemical structure, C16H12Cl2N2O2, CAS 848-75-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
848-75-9
Formula
C16H12Cl2N2O2
Molar mass
335.19 g/mol
EC number
212-700-5
HS code
293391
Category
Central nervous system drugs

What is Lormetazepam?

Plain description, key identifiers and synonyms

Lormetazepam is a 1,4-benzodiazepinone compound having a methyl substituent at the 1-position, a hydroxy substituent at the 3-position, a 2-chlorophenyl group at the 5-position and a chloro substituent at the 7-position. It has a role as a sedative. It is a 1,4-benzodiazepinone and an organochlorine compound.

Lormetazepam is a benzodiazepine derivative medication.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3H-1,4-benzodiazepin-2-one
CAS number
848-75-9 CAS number cross-checked
EC number
212-700-5
Molecular formula
C16H12Cl2N2O2
UNII
GU56C842ZA
InChIKey
FJIKWRGCXUCUIG-UHFFFAOYSA-N
InChI
InChI=1S/C16H12Cl2N2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3
SMILES (canonical and isomeric)
CN1C2=C(C=C(C=C2)Cl)C(=NC(C1=O)O)C3=CC=CC=C3Cl

Synonyms

  • Methyllorazepam
  • N-Methyllorazepam
  • Loramet
  • Lormetazepamum
  • Chlorotemazepam
  • 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one
  • 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one
  • 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
  • 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3H-1,4-benzodiazepin-2-one
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-
  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-
  • 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • (+-)-Lormetazepam
  • Noctamid
  • Ergocalm
  • Noctamide
  • Loramet (TN)
  • Ro 5-5516
  • WY 4082
  • Loretam
  • Lormetazepam (1.0mg/ml in Acetonitrile)
  • (RS)-Lormetazepam
  • (+/-)-Lormetazepam
  • Dormagen
  • DEA No. 2774
Show all 30 synonyms
  • ()-Lorazepam
  • Lormetazepam (JAN/USAN/INN)
  • Lormetazepam 0.1 mg/ml in Methanol
  • Lormetazepam 1.0 mg/ml in Methanol
  • Lormetazepam, 1mg/ml in Acetonitrile

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
335.19 g/molcalc.
Exact mass
334.0276 Dacalc.
LogP (octanol/water)
3.13calc.
Topological polar surface area
52.9 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
22calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.13calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CN=C(c2ccccc2)c2ccccc2N1

O=C1CN=C(c2ccccc2)c2ccccc2N1

3 rings, 18 atoms, the RO-05-2921 ring system.

540 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H319Causes serious eye irritation.
  • H336May cause drowsiness or dizziness.
  • H360May damage fertility or the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
  • H362May cause harm to breast-fed children.
Precautionary statements (17)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P337 + P317If eye irritation persists: Get medical help.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Lormetazepam suppliers

Trading restrictions apply to this substance

Psychotropic substance

Lormetazepam is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2933.91 (benzodiazepines and related substances)

Our policy on controlled substances

Lormetazepam price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Hypnotics and Sedatives

Roles

  • antidepressant
  • antipsychotic agent
  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • pharmaceutical
  • psychotropic drug
  • sedative
  • tranquilizing drug

Regulatory status

Inventories, regulations and trade controls that list this substance

Psychotropic substance

Lormetazepam is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2933.91 (benzodiazepines and related substances)

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled psychotropic substance

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Lormetazepam is traded under.

HS 2933.91Exact HS code

Alprazolam (INN), camazepam (INN), chlordiazepoxide (INN), clonazepam (INN)…

World exports in 2024
$118M
−26.3% vs 2023, imports $94.2M
2019 to 2024
Top exporters
  1. Italy37.7%
  2. United States22.7%
  3. India * partner reported9.8%
Top importers
  1. Germany13.8%
  2. Spain10.4%
  3. United States10.2%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Lormetazepam is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Lormetazepam, based on the data on this page

What is Lormetazepam?

Lormetazepam is a 1,4-benzodiazepinone compound having a methyl substituent at the 1-position, a hydroxy substituent at the 3-position, a 2-chlorophenyl group at the 5-position and a chloro substituent at the 7-position. It has a role as a sedative. It is a 1,4-benzodiazepinone and an organochlorine compound.

What is the CAS number of Lormetazepam?

The CAS registry number of Lormetazepam is 848-75-9.

What is the molecular formula and weight of Lormetazepam?

The molecular formula of Lormetazepam is C16H12Cl2N2O2 and its molar mass is 335.19 g/mol.

What is Lormetazepam used for?

Use classes: Pharmaceuticals.

Is Lormetazepam hazardous?

Lormetazepam carries the GHS signal word "Danger". Main hazards: causes serious eye irritation, may cause drowsiness or dizziness, may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Lormetazepam?

Lormetazepam is usually classified under HS code 293391 (Alprazolam (INN), camazepam (INN), chlordiazepoxide (INN), clonazepam (INN)…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Lormetazepam on CompoundList?

No. Lormetazepam is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Lormetazepam

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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