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Murcko scaffold

RO-05-2921 scaffold

541 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
541
With full pages
113
Scaffold SMILES

O=C1CN=C(c2ccccc2)c2ccccc2N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the RO-05-2921 page
Murcko scaffold O=C1CN=C(c2ccccc2)c2ccccc2N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 541 chemicals

Ro 5-4864 chemical structure, C16H12Cl2N2O, CAS 14439-61-3
Ro 5-4864
CAS 14439-61-3C16H12Cl2N2O
Clonazepam chemical structure, C15H10ClN3O3, CAS 1622-61-3
Clonazepam
CAS 1622-61-3C15H10ClN3O3
Clorazepate chemical structure, C16H11ClN2O3, CAS 23887-31-2
Clorazepate
CAS 23887-31-2C16H11ClN2O3
Nordiazepam chemical structure, C15H11ClN2O, CAS 1088-11-5
Nordiazepam
CAS 1088-11-5C15H11ClN2O
Diazepam chemical structure, C16H13ClN2O, CAS 439-14-5
Diazepam
CAS 439-14-5C16H13ClN2O
Ethyl loflazepate chemical structure, C18H14ClFN2O3, CAS 29177-84-2
Ethyl loflazepate
CAS 29177-84-2C18H14ClFN2O3
Fludiazepam chemical structure, C16H12ClFN2O, CAS 3900-31-0
Fludiazepam
CAS 3900-31-0C16H12ClFN2O
Flunitrazepam chemical structure, C16H12FN3O3, CAS 1622-62-4
Flunitrazepam
CAS 1622-62-4C16H12FN3O3
Flurazepam chemical structure, C21H23ClFN3O, CAS 17617-23-1
Flurazepam
CAS 17617-23-1C21H23ClFN3O
Lorazepam chemical structure, C15H10Cl2N2O2, CAS 846-49-1
Lorazepam
CAS 846-49-1C15H10Cl2N2O2
Nimetazepam chemical structure, C16H13N3O3, CAS 2011-67-8
Nimetazepam
CAS 2011-67-8C16H13N3O3
Nitrazepam chemical structure, C15H11N3O3, CAS 146-22-5
Nitrazepam
CAS 146-22-5C15H11N3O3
Desalkylflurazepam chemical structure, C15H10ClFN2O, CAS 2886-65-9
Desalkylflurazepam
CAS 2886-65-9C15H10ClFN2O
Oxazepam chemical structure, C15H11ClN2O2, CAS 604-75-1
Oxazepam
CAS 604-75-1C15H11ClN2O2
Temazepam chemical structure, C16H13ClN2O2, CAS 846-50-4
Temazepam
CAS 846-50-4C16H13ClN2O2
Lormetazepam chemical structure, C16H12Cl2N2O2, CAS 848-75-9
Lormetazepam
CAS 848-75-9C16H12Cl2N2O2
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-1-(3-(dimethylamino)propyl)-5-phenyl- chemical structure, C20H22ClN3O, CAS 1100-25-0
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-1-(3-(dimethylamino)propyl)-5-phenyl-
CAS 1100-25-0C20H22ClN3O
1,3-Dihydro-7-nitro-5-(alpha,alpha,alpha-trifluoro-o-tolyl)2H-1,4-benzodiazepin-2-one chemical structure, C16H10F3N3O3, CAS 1427-45-8
1,3-Dihydro-7-nitro-5-(alpha,alpha,alpha-trifluoro-o-tolyl)2H-1,4-benzodiazepin-2-one
CAS 1427-45-8C16H10F3N3O3
1,3-Dihydro-5-phenyl-7-(trifluoromethyl)-2H-1,4-benzodiazepin-2-one chemical structure, C16H11F3N2O, CAS 2285-16-7
1,3-Dihydro-5-phenyl-7-(trifluoromethyl)-2H-1,4-benzodiazepin-2-one
CAS 2285-16-7C16H11F3N2O
Lorazepam acetate chemical structure, C17H12Cl2N2O3, CAS 2848-96-6
Lorazepam acetate
CAS 2848-96-6C17H12Cl2N2O3
Delorazepam chemical structure, C15H10Cl2N2O, CAS 2894-67-9
Delorazepam
CAS 2894-67-9C15H10Cl2N2O
2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepine-7-carbonitrile chemical structure, C17H13N3O, CAS 3489-59-6
2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepine-7-carbonitrile
CAS 3489-59-6C17H13N3O
7-Chloro-1-[3-(dimethylamino)propyl]-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one chemical structure, C20H21ClFN3O, CAS 4699-79-0
7-Chloro-1-[3-(dimethylamino)propyl]-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
CAS 4699-79-0C20H21ClFN3O
2,3-Dihydro-7-nitro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid chemical structure, C16H11N3O5, CAS 60676-80-4
2,3-Dihydro-7-nitro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid
CAS 60676-80-4C16H11N3O5