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Aldehydes and ketones

Malonaldehyde

Also known as Propanedial, Malondialdehyde, Malonodialdehyde

CAS 542-78-9Formula C3H4O2Molar mass 72.06 g/mol
32 suppliers listed
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Malonaldehyde chemical structure, C3H4O2, CAS 542-78-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
542-78-9
Formula
C3H4O2
Appearance
Solid (needles)
Melting point
72 °C
HS code
291219
Category
Aldehydes and ketones
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Malonaldehyde?

Plain description, key identifiers and synonyms

Malonaldehyde is a dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form. It has a role as a biomarker.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
propanedial
CAS number
542-78-9 CAS number cross-checked
Molecular formula
C3H4O2
UNII
4Y8F71G49Q
InChIKey
WSMYVTOQOOLQHP-UHFFFAOYSA-N
InChI
InChI=1S/C3H4O2/c4-2-1-3-5/h2-3H,1H2
SMILES (canonical and isomeric)
C(C=O)C=O

Synonyms

  • Propanedial
  • Malondialdehyde
  • Malonodialdehyde
  • Malonic aldehyde
  • Malonyldialdehyde
  • Malonic dialdehyde
  • 1,3-Propanedial
  • 1,3-Propanedione
  • 1,3-Propanedialdehyde
  • Malonylaldehyde
  • malonicdialdehyde
  • Malondialdehyde, Sodium
  • MDD
  • beta-ketopropionaldehyde
  • Malondialdehyde potassium
  • 4-01-00-03634 (Beilstein Handbook Reference)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Solid (needles)exp.
Melting point
72 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
72.06 g/molcalc.
Exact mass
72.0211 Dacalc.
LogP (octanol/water)
-0.23calc.
Topological polar surface area
34.14 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
2calc.
Heavy atoms
5calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Malonaldehyde suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 32 suppliers
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Where suppliers are based

32 suppliers in 7 countries

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Malonaldehyde price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Research compound.

Roles

  • biomarker
  • indicator

Pharmacology

Malondialdehyde is an organic compound with the formula CH2(CHO)2, and a byproduct of lipid metabolism in the body. Malondialdehyde, a highly reactive compound, is one of the many reactive electrophile species that cause toxic stress in cells and form covalent protein adducts, called advanced lipoxidation end products (ALE). This compound also forms mutagenic DNA adducts when it reacts with deoxyadenosine and deoxyguanosine in DNA. Malondialdehyde is also found in many foods and is present in high levels in rancid foods.

How it is made

FREE MALONALDEHYDE CAN BE GENERATED FROM/ITS BIS(DIALKYL)ACETALS (eg 1,1,3,3-TETRAETHOXYPROPANE)/BY ACID-CATALYZED HYDROLYSIS WITH DILUTE HYDROCHLORIC ACID OR SHAKING THEM WITH ACID DOWEX 50 ION-EXCHANGE RESIN

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Malonaldehyde is traded under.

HS 2912.19Indicative HS code

Acyclic aldehydes without other oxygen function, other

World exports in 2024
$679M
+4.8% vs 2023, imports $743M
2019 to 2024
Top exporters
  1. Germany22.0%
  2. China21.2%
  3. United States18.5%
Top importers
  1. United States13.1%
  2. Germany9.6%
  3. Belgium8.2%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Malonaldehyde is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Malonaldehyde, based on the data on this page

What is Malonaldehyde?

Malonaldehyde is a dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form. It has a role as a biomarker.

What is the CAS number of Malonaldehyde?

The CAS registry number of Malonaldehyde is 542-78-9.

What is the molecular formula and weight of Malonaldehyde?

The molecular formula of Malonaldehyde is C3H4O2 and its molar mass is 72.06 g/mol.

What is Malonaldehyde used for?

Research compound.

Is Malonaldehyde hazardous?

No GHS hazard classification for Malonaldehyde is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Malonaldehyde?

Malonaldehyde is usually classified under HS code 291219 (Acyclic aldehydes without other oxygen function, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Malonaldehyde?

CompoundList lists 32 suppliers of Malonaldehyde in United States, China, Spain, United Kingdom and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Malonaldehyde?

Suppliers quote Malonaldehyde on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Malonaldehyde

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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