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Sweeteners

Mannitol

Also known as D-mannitol, Mannite, Osmitrol

CAS 69-65-8Formula C6H14O6Molar mass 182.17 g/molEC 200-711-8
255 suppliers listed Drug substance
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Mannitol chemical structure, C6H14O6, CAS 69-65-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Orthorhombic needles from alc
Melting point
166 to 168
Boiling point
290 to 295
Density
1.52 @ 20 °C
Flash point
>148.9
HS code
290543
Category
Sweeteners
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Mannitol?

Plain description, key identifiers and synonyms

D-mannitol is the D-enantiomer of mannitol. It has a role as a member of compatible osmolytes, a metabolite, an antiglaucoma drug, an osmotic diuretic, a sweetening agent, an allergen, a hapten, an Escherichia coli metabolite, a food anticaking agent, a food stabiliser, a food humectant, a food thickening agent and a food bulking agent.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
CAS number
69-65-8 CAS number cross-checkedOther or deprecated CAS: 133-43-7, 85085-15-0, 87-78-5
EC numbers
200-711-8, 201-770-2
Molecular formula
C6H14O6
UNII
3OWL53L36A
MDL number
MFCD00064287
INCI name
MANNITOL
InChIKey
FBPFZTCFMRRESA-KVTDHHQDSA-N
InChI
InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
Canonical SMILES
OCC(O)C(O)C(O)C(O)CO
Isomeric SMILES
C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O

Synonyms

  • D-mannitol
  • Mannite
  • Osmitrol
  • Manna sugar
  • Cordycepic acid
  • Diosmol
  • Resectisol
  • Mannidex
  • Mannigen
  • Osmosal
  • Mannit
  • D-(-)-Mannitol
  • Mannazucker
  • Mannistol
  • Invenex
  • Isotol
  • Mannitol, D-
  • Marine Crystal
  • Maniton-S
  • Mannogem 2080
  • Bronchitol
  • (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol
  • (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
  • Mannitol 5%
  • Aridol
Show all 39 synonyms
  • Mannitol 10%
  • Mannitol 15%
  • Mannitol 20%
  • Osmitrol 5% In Water
  • Osmitrol 10% In Water
  • Osmitrol 15% In Water
  • Osmitrol 20% In Water
  • Mannitol 25%
  • Resectisol In Plastic Container
  • Mannitol (USP)
  • Mannitol 5% In Plastic Container
  • Mannitol 10% In Plastic Container
  • Mannitol 15% In Plastic Container
  • Mannitol 20% In Plastic Container

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Orthorhombic needles from alcexp.
Odour
Odorlessexp.
Taste
Sweetish tasteexp.
Melting point
166 to 168exp.
Boiling point
290 to 295exp.
Density
1.52 @ 20 °Cexp.
Flash point
>148.9exp.
Solubility
1 g in about 5.5 ml water, more sol in hot water, insol in ether, sol in pyridine, aniline, sol in aq soln of alkalies, 1 g dissolves in 18 ml glycerol (density 1.24), 1 g dissolves in about 83 ml alcexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
182.17 g/molcalc.
Exact mass
182.079 Dacalc.
LogP (octanol/water)
-3.59calc.
Topological polar surface area
121.4 Ųcalc.
Hydrogen bond donors
6calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
5calc.
Heavy atoms
12calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS classification
Hazard pictograms

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Mannitol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 255 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

255 suppliers in 46 countries

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Mannitol price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Used in the food industry as anti-caking and free flowing agent, stabilizer, thickener, and non-nutritive sweetener.

Mannitol...used in various ways: (1) as flavor carrier or flavor-encapsulating agent, (2) as flavor enhancer in wide variety of products, such as coffee concentrates, meat-curing composition, flavor additives for nuts, & pure juice concentrates, & (3) in number of flavor-enhancing compositions.

Veterinary medication:.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name MANNITOL(binding, humectant, fragrance, moisturising)

Pharmacological actions

  • Diuretics, Osmotic
  • Sweetening Agents

Roles

  • Escherichia coli metabolite
  • additive
  • aetiopathogenetic role
  • allergen
  • anticaking agent
  • antiglaucoma drug
  • compatible osmolytes
  • diuretic
  • filler
  • flavouring agent
  • food additive
  • food anticaking agent
  • food bulking agent
  • food humectant
  • food stabiliser
  • food thickening agent
  • hapten
  • humectant
  • metabolite
  • ophthalmology drug
  • osmotic diuretic
  • pharmaceutical
  • stabilizer
  • sweetening agent

Functional uses

  • Anti-caking agent
  • Binder
  • Deodorizer
  • Flavouring and nutrient
  • Fragrance
  • Humectant
  • Lubricating agent
  • Processing aids not otherwise specified
  • Softener and conditioner
  • Solvent

Cosmetic functions

  • Binding
  • Fragrance
  • Humectant
  • Moisturising
  • Skin conditioning

Pharmacology

Mannitol is an Osmotic Diuretic. The mechanism of action of mannitol is as an Osmotic Activity. The physiologic effect of mannitol is by means of Increased Diuresis.

How it is made

By electrolytic reduction of glucose. Prepn from seaweed, by hydrogenation of invert sugar, monosaccharides, & sucrose.

May be extracted from manna and other natural sources with hot alcohol or other selective solvents. Commercially it is produced by catalytic or electrolytic reduction of certain monosaccharides such as mannose and glucose. Manufacture is somewhat complicated by the need for separation of stereoisomers

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Mannitol is traded under.

HS 2905.43Exact HS code

Alcohols: polyhydric, mannitol

World exports in 2024
$347M
+11.9% vs 2023, imports $355M
2019 to 2024
Top exporters
  1. France * partner reported47.8%
  2. China22.8%
  3. United States9.8%
Top importers
  1. United States13.5%
  2. India * partner reported8.7%
  3. Japan8.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Mannitol is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Mannitol, based on the data on this page

What is Mannitol?

D-mannitol is the D-enantiomer of mannitol. It has a role as a member of compatible osmolytes, a metabolite, an antiglaucoma drug, an osmotic diuretic, a sweetening agent, an allergen, a hapten, an Escherichia coli metabolite, a food anticaking agent, a food stabiliser, a food humectant, a food thickening agent and a…

What is the CAS number of Mannitol?

The CAS registry number of Mannitol is 69-65-8. Other or deprecated CAS numbers: 133-43-7, 85085-15-0, 87-78-5.

What is the molecular formula and weight of Mannitol?

The molecular formula of Mannitol is C6H14O6 and its molar mass is 182.17 g/mol.

What is Mannitol used for?

Used in the food industry as anti-caking and free flowing agent, stabilizer, thickener, and non-nutritive sweetener.

Is Mannitol hazardous?

No GHS hazard classification for Mannitol is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Mannitol?

Mannitol is usually classified under HS code 290543 (Mannitol). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Mannitol?

CompoundList lists 255 suppliers of Mannitol in China, India, United States, Germany and 42 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Mannitol in India?

41 suppliers in India list Mannitol on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Mannitol?

Suppliers quote Mannitol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Mannitol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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