Melphalan safety data

GHS hazards, precautions, first aid, handling and transport for Melphalan. A classification summary, not a safety data sheet.

CAS 148-82-3Formula C₁₃H₁₈Cl₂N₂O₂

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

GHS classification

Pictograms, signal word and hazard classes of the GHS classification

Acute toxicity (severe)

Serious health hazard

Signal word

Danger

Hazard classes and categories

Acute Tox. 1/2 (oral)
Acute Tox. 1/2 (dermal)
Acute Tox. 1/2 (inhalation)
Muta. 1A/1B
Carc. 1A/1B
Repr. 2

Hazard statements

H codes grouped by type. Percentages show the share of classification notifications that report the statement

Health hazards

H300Fatal if swallowed.
H310Fatal in contact with skin.
H330Fatal if inhaled.
H340May cause genetic defects.
H350May cause cancer.
H361Suspected of damaging fertility or the unborn child.

Precautionary statements

P codes for prevention, response, storage and disposal

Prevention

P203Obtain, read and follow all safety instructions before use.
P260Do not breathe dust, fume, gas, mist, vapours or spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash skin thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves, protective clothing, eye protection and face protection.
P284In case of inadequate ventilation wear respiratory protection.

Response

P301 + P316If swallowed: Get emergency medical help immediately.
P302 + P352If on skin: Wash with plenty of water.
P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
P316Get emergency medical help immediately.
P318If exposed or concerned, get medical advice.
P320Specific treatment is urgent (see supplemental first aid instructions on the label).
P321Specific treatment (see supplemental first aid instructions on the label).
P330Rinse mouth.
P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.

Storage

P403 + P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.

Disposal

P501Dispose of contents and container in accordance with local regulations.

First aid

General first aid measures. Get medical advice if you feel unwell

If inhaled

IMMEDIATELY leave the contaminated area, take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used, if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

Skin contact

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

Eye contact

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

If swallowed

If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure th…

Handling, storage and disposal

Summaries only, follow the supplier SDS for your grade

Safe handling

Eye/face protection: Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection: Handle with gloves.

Storage

Keep container tightly closed in a dry and well-ventilated place. Melphalan tablets should be stored in well-closed, light-resistant, glass containers at temp less than 40 °C, preferably between 15-30 °C.

Disposal

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U150, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste. SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal.

Exposure limits and toxicity

Occupational exposure limits and toxicity data

Epidemiological studies found that patients treated with melphalan for breast cancer, ovarian cancer, and bone-marrow cancer (multiple myeloma) had an increased risk of leukemia. The risk of leukemia increased with increasing dose of melphalan but was not affected by co-exposure to radiation therapy. Melphalan produces chromatid-type aberrations in peripheral blood lymphocytes taken from cancer patients.

Transport information

UN dangerous goods classification for road, sea and air

UN number: UN 2811

Shipping rules depend on mode, quantity and packaging. Confirm the classification with the supplier SDS and your freight forwarder.

Supplier safety data sheets

SDS documents uploaded by suppliers who list this chemical

No supplier has uploaded an SDS for Melphalan yet. Suppliers usually send one with their quote. Request quotes

Safety questions

Quick answers about handling Melphalan safely

Is Melphalan hazardous?

Melphalan carries the GHS signal word "Danger". Main hazards: fatal if swallowed, fatal in contact with skin, fatal if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

Which GHS pictograms apply to Melphalan?

The GHS classification of Melphalan shows 2 pictograms: GHS06 (acute toxicity (severe)), GHS08 (serious health hazard).

What is the UN number of Melphalan?

Melphalan is transported under UN 2811. Check the supplier SDS and the current ADR, IMDG or IATA rules before shipping.

How should Melphalan be stored?

Where can I get the SDS for Melphalan?

Ask the supplier for the safety data sheet of the exact grade you buy. Suppliers on CompoundList can attach their SDS to listings and send it with a quote. This page is a GHS classification summary, not an SDS.

GHS classification summary, not an SDS. Always check the supplier's SDS. Last updated 7 Oct 2026. Report an error

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