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Screening compounds

Mericitabine

Also known as PSI 6130 diisobutyrate, Mericitabina, RG 7128

CAS 940908-79-2Formula C18H26FN3O6Molar mass 399.42 g/mol
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Mericitabine chemical structure, C18H26FN3O6, CAS 940908-79-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
940908-79-2
Formula
C18H26FN3O6
Molar mass
399.42 g/mol
HS code
293499
Category
Screening compounds

What is Mericitabine?

Plain description, key identifiers and synonyms

Mericitabine is an orally available prodrug of PSI-6130 which is a selective cytidine nucleoside analogue and non-cytotoxic hepatitis C virus (HCV) polymerase inhibitor. After intracellular uptake, mericitabine is phosphorylated into two active triphosphate metabolites, which disable HCV RNA-dependent RNA polymerase (non-structural protein 5B, NS5B) upon binding. This results in the blockage of viral HCV RNA production and thus viral replication. This agent has a high barrier to resistance, however, a substitution mutation (S282T) on HCV NS5B impairs mericitabine's activity significantly.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4-fluoro-4-methyl-3-(2-methylpropanoyloxy)oxolan-2-yl]methyl 2-methylpropanoate
CAS number
940908-79-2 CAS number cross-checked
Molecular formula
C18H26FN3O6
UNII
TA63JX8X52
MDL number
MFCD22572932
InChIKey
MLESJYFEMSJZLZ-MAAOGQSESA-N
InChI
InChI=1S/C18H26FN3O6/c1-9(2)14(23)26-8-11-13(28-15(24)10(3)4)18(5,19)16(27-11)22-7-6-12(20)21-17(22)25/h6-7,9-11,13,16H,8H2,1-5H3,(H2,20,21,25)/t11-,13-,16-,18-/m1/s1
Canonical SMILES
CC(C)C(=O)OCC1OC(n2ccc(N)nc2=O)C(C)(F)C1OC(=O)C(C)C
Isomeric SMILES
CC(C)C(=O)OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=NC2=O)N)(C)F)OC(=O)C(C)C

Synonyms

  • PSI 6130 diisobutyrate
  • Mericitabina
  • RG 7128
  • 3',5'-Diisobutyryl PSI 6130
  • 3',5'-Diisobutyryl psi6130
  • Psi6130 diisobutyrate
  • 2'-Deoxy-2'-fluoro-2'-C-methylcytidine diisobutyrate
  • 2'-Fluoro-2'-methyl-3',5'-diisobutyryldeoxycytidine
  • Cytidine, 2'-deoxy-2'-fluoro-2'-methyl-, 3',5'-bis(2-methylpropanoate), (2'R)-
  • mericitabinum
  • Ro5024048, r7128
  • 2' alpha-fluoro-2' beta-methyl-3',5'-diisobutyryldeoxycytidine
  • ((2R,3R,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-4-fluoro-4-methyl-3-((2-methylpropanoyl)oxy)oxolan-2-yl)methyl 2-methylpropanoate
  • (2R,3R,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-4-fluoro-2-((isobutyryloxy)methyl)-4-methyltetrahydrofuran-3-yl isobutyrate
  • [(2R,3R,4R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-4-fluoro-4-methyl-3-(2-methylpropanoyloxy)oxolan-2-yl]methyl 2-methylpropanoate
  • (2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate)
  • R-7128,CAS:940908-79-2
  • 2'.Alpha.-fluoro-2'.beta.-methyl-3',5'-diisobutyryldeoxycytidine
  • [(2R,3R,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-4-fluoro-4-methyl-3-(2-methylpropanoyloxy)tetrahydrofuran-2-yl]methyl 2-methylpropanoate
  • Mericitabine, 97%
  • RG 7128, R-7128, PSI 6130 diisobutyrate
  • R-7128(Mericitabine)
  • Mericitabine (USAN/INN)
  • (2R,3R,4R,5R)-5-(4-Ami
  • RG 7128, Mericitabine, PSI 6130 diisobutyrate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
399.42 g/molcalc.
Exact mass
399.1806 Dacalc.
LogP (octanol/water)
1.22calc.
Topological polar surface area
122.7 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
6calc.
Heavy atoms
28calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1ncccn1C1CCCO1

O=c1ncccn1C1CCCO1

2 rings, 12 atoms.

1,589 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Mericitabine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 2 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

2 suppliers in 1 country

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Mericitabine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antimicrobial agent
  • antiviral agent

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Mericitabine is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Mericitabine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Mericitabine, based on the data on this page

What is Mericitabine?

Mericitabine is an orally available prodrug of PSI-6130 which is a selective cytidine nucleoside analogue and non-cytotoxic hepatitis C virus (HCV) polymerase inhibitor.

What is the CAS number of Mericitabine?

The CAS registry number of Mericitabine is 940908-79-2.

What is the molecular formula and weight of Mericitabine?

The molecular formula of Mericitabine is C18H26FN3O6 and its molar mass is 399.42 g/mol.

What is Mericitabine used for?

Known uses and roles of Mericitabine include building blocks in research and laboratory, screening compounds in research and laboratory, antimicrobial agent and antiviral agent.

Is Mericitabine hazardous?

No GHS hazard classification for Mericitabine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Mericitabine?

Mericitabine is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Mericitabine?

CompoundList lists 2 suppliers of Mericitabine in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Mericitabine?

Suppliers quote Mericitabine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Mericitabine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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