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Insecticides and acaricides

Methidathion

Also known as Supracide, Ultracide, Suprathion

CAS 950-37-8Formula C6H11N2O4PS3Molar mass 302.34 g/molEC 213-449-4
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Hazardous to the environment 9 suppliers listed
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Methidathion chemical structure, C6H11N2O4PS3, CAS 950-37-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless crystals
Melting point
39 °C
Density
1.51 g/cm³ (20 °C)
Flash point
100 °C
Solubility
In water, 187 mg/L at 20 °C
HS code
293499
Category
Insecticides and acaricides
UN number
UN 2811
Illustrative photo, colourless crystals in small glass vials on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Methidathion?

Plain description, key identifiers and synonyms

Methidathion is an organothiophosphate insecticide and an organic thiophosphate. It has a role as an acaricide, an agrochemical and an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is functionally related to a 5-methoxy-1,3,4-thiadiazol-2(3H)-one.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-(dimethoxyphosphinothioylsulfanylmethyl)-5-methoxy-1,3,4-thiadiazol-2-one
CAS number
950-37-8 CAS number cross-checked
EC number
213-449-4
Molecular formula
C6H11N2O4PS3
UNII
Y2P145U7KK
MDL number
MFCD00055286
InChIKey
MEBQXILRKZHVCX-UHFFFAOYSA-N
InChI
InChI=1S/C6H11N2O4PS3/c1-10-5-7-8(6(9)16-5)4-15-13(14,11-2)12-3/h4H2,1-3H3
SMILES (canonical and isomeric)
COC1=NN(C(=O)S1)CSP(=S)(OC)OC

Synonyms

  • Supracide
  • Ultracide
  • Suprathion
  • Somonil
  • Supracid
  • Ultracid
  • Methidathion 50S
  • Ultracid 40
  • Ultracid EC 40
  • DMTP (insecticide)
  • Supracide Ulvair
  • Fisons NC 2964
  • Geigy 13005
  • Metidation
  • Ciba-Geigy GS 13005
  • Ultracide Ulvair 250
  • Geigy GS-13005
  • OMS 844
  • GS 13005
  • ENT 27193
  • Suprathim
  • S-(2,3-Dihydro-5-methoxy-2-oxo-1,3,4-thiadiazol-3-methyl) dimethyl phosphorothiolothionate
  • Dithiophosphoric acid O,O'-dimethyl-S-((2-methoxy-1,3,4-thiadiazol-5(4H)-on-4-yl)methyl) ester
  • S-((5-Methoxy-2-oxo-1,3,4-thiadiazol-3(2H)-yl)methyl) O,O-dimethyl phosphorodithioate
  • S-2,3-Dihydro-5-methoxy-2-oxo-1,3,4-thiadiazol-3-ylmethyl O,O-dimethyl phosphorodithioate
Show all 39 synonyms
  • O,O'-Dimethyl-S-((2-methoxy-1,3,4-thiadiazole-5(4H)-one-4-yl)methyl) dithiophosphate
  • O,O-Dimethyl-S-(2-methoxy-1,3,4-thiadiazol-5(4H)-onyl-(4)-methyl) phosphorodithioate
  • Phosphorodithioic acid, S-[(5-methoxy-2-oxo-1,3,4-thiadiazol-3(2H)-yl)methyl] O,O-dimethyl ester
  • S-2-Metoksy-1,3,4-tiadiazolo-5-on-N-metylo-O,O-dwumetylowy
  • 3-Dimethoxyphosphinothioylthiomethyl-5-methoxy-1,3,4-thiadiazol-2(3H)-one
  • O,O-Dimethyl S-(5-methoxy-1,3,4-thiadiazolinyl-3-methyl)dithiophosphate
  • O,O-Dimetil-S-((2-metossi-1,3,4-(4H)-tiadiazol-5-on-4-il)-metil)-ditiofosfato
  • (O,O-Dimethyl)-S-(-2-methoxy-delta(sup 2)-1,3,4-thiadiazolin-5-on-4-ylmethyl)dithiophosphate
  • O,O-Dimethyl S-(2,3-dihydro-5-methoxy-2-oxo-1,3,4-thiadiazol-3-ylmethyl) phosphorodithioate
  • S-(2,3-Dihydro-5-methoxy-2-oxo-1,3,4-thiadiazol-3-methyl)dimethyl phosphorothiolothionate
  • S-[(5-Methoxy-2-oxo-1,3,4-thiadiazol-3(2H)-yl)methyl] o,o-dimethyl dithiophosphate
  • Phosphorodithioic acid, O,O-dimethyl ester, S-ester with 4-(mercaptomethyl)-2-methoxy-delta(2)-1,3,4-thiadiazolin-5-one
  • Phosphorodithioic acid, O,O-dimethyl ester, S-ester with 4-(mercaptomethyl)-2-methoxy-delta(sup 2)-1,3,4-thiadiazolin-5-one
  • Phosphorodithioic acid, S-((5-methoxy-2-oxo-1,3,4-thiadiazol-3(2H)-yl)methyl) O,O-dimethyl ester

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless crystalsexp.
Odour
Organophosphate odorexp.
Melting point
39 °Cexp.
Density
1.51 g/cm³ (20 °C)exp.
Flash point
100 °Cexp.
Solubility
In water, 187 mg/L at 20 °Cexp.
Vapour pressure
3.37 × 10⁻⁶ mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
302.34 g/molcalc.
Exact mass
301.9619 Dacalc.
LogP (octanol/water)
1.52calc.
Topological polar surface area
62.58 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
6calc.
Heavy atoms
16calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1[nH]ncs1

O=c1[nH]ncs1

1 ring, 6 atoms, the 1,3,4-Thiadiazol-2-ol ring system.

70 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H300Fatal if swallowed.
  • H312Harmful in contact with skin.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (13)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2811
Transport hazard class
6.1
Packing group
II

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Methidathion suppliers

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All 9 suppliers
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Where suppliers are based

9 suppliers in 3 countries

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Methidathion price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Insecticide, acaricide.

Alfalfa weevil in alfalfa, scales in citrus, spider mites, bollworm, budworm, lygus bug, and whitefly in cotton.

Control of a wide range of sucking and chewing insects (especially scale insects) and spider mites in many crops.

Use classes: Insecticides, Acaricides, Insecticides.

Pharmacological actions

  • Insecticides

Roles

  • acaricide
  • agrochemical
  • enzyme inhibitor
  • pesticide

Functional uses

  • Biocide

Pharmacology

Methidathion is a synthetic organic thiophosphate compound and organophosphate acetylcholinesterase inhibitor that is used as a pesticide. It is characterized as a colorless crystalline solid, and exposure occurs by inhalation, ingestion, or contact.

How it is made

The treatment of 2-methoxy-1,3,4-thiadiazol-5(4h)-one with formaldehyde, conversion to the 4-halogenmethyl derivative with thionyl chloride or phosphorus tribromide, & reaction with dimethyl hydrogen phosphorodithioate.

Methidathion is produced by reaction of 2-methoxy-1,3,4-thiadiazol-5(4H)-one with dimethyldithiophosphoric acid via the N-chloromethyl derivative or in a one-step reaction in the presence of formaldehyde.

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 015-069-00-2

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Methidathion is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Methidathion is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Methidathion, based on the data on this page

What is Methidathion?

Methidathion is an organothiophosphate insecticide and an organic thiophosphate. It has a role as an acaricide, an agrochemical and an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is functionally related to a 5-methoxy-1,3,4-thiadiazol-2(3H)-one.

What is the CAS number of Methidathion?

The CAS registry number of Methidathion is 950-37-8.

What is the molecular formula and weight of Methidathion?

The molecular formula of Methidathion is C6H11N2O4PS3 and its molar mass is 302.34 g/mol.

What is Methidathion used for?

Insecticide, acaricide. Alfalfa weevil in alfalfa, scales in citrus, spider mites, bollworm, budworm, lygus bug, and whitefly in cotton. Control of a wide range of sucking and chewing insects (especially scale insects) and spider mites in many crops. Use classes: Insecticides, Acaricides, Insecticides.

Is Methidathion hazardous?

Methidathion carries the GHS signal word "Danger". Main hazards: fatal if swallowed, harmful in contact with skin, very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Methidathion?

Methidathion is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Methidathion?

CompoundList lists 9 suppliers of Methidathion in China, India and Singapore. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Methidathion in India?

1 supplier in India list Methidathion on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Methidathion?

Suppliers quote Methidathion on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Methidathion

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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