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Hormones and steroids

Methimazole

Also known as thiamazole, Tapazole, 1-Methyl-1H-imidazole-2-thiol

CAS 60-56-0Formula C4H6N2SMolar mass 114.17 g/molEC 200-482-4
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 131 suppliers listed Drug substance
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Methimazole chemical structure, C4H6N2S, CAS 60-56-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Leaflets from alcohol
Melting point
146 to 148
Boiling point
280 °C
Solubility
1 G SOL IN ABOUT 125 ML ETHER, ABOUT 4.5 ML CHLOROFORM, ABOUT 5 ML WATER, 5 ML ALCOHOL
HS code
293329
Category
Hormones and steroids
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Methimazole?

Plain description, key identifiers and synonyms

Methimazole is a member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen. It has a role as an antithyroid drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-methyl-1H-imidazole-2-thione
CAS number
60-56-0 CAS number cross-checkedOther or deprecated CAS: 223768-14-7, 85916-84-3
EC number
200-482-4
Molecular formula
C4H6N2S
UNII
554Z48XN5E
MDL number
MFCD00179321
InChIKey
PMRYVIKBURPHAH-UHFFFAOYSA-N
InChI
InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
SMILES (canonical and isomeric)
CN1C=CNC1=S

Synonyms

  • thiamazole
  • Tapazole
  • 1-Methyl-1H-imidazole-2-thiol
  • Methimazol
  • 1-Methylimidazole-2-thiol
  • Mercazolyl
  • Thiamazol
  • Mercazole
  • Thymidazol
  • Thymidazole
  • Favistan
  • Mercaptazole
  • Metothyrine
  • Metazolo
  • Metothyrin
  • Strumazol
  • Thycapzol
  • Danantizol
  • Frentirox
  • Merkazolil
  • Metotirin
  • Thacapzol
  • Basolan
  • Mercasolyl
  • Metizol
Show all 39 synonyms
  • Tiamazol
  • Methylmercaptoimidazole
  • Usaf el-30
  • 1-Methyl-2-mercaptoimidazole
  • 2H-Imidazole-2-thione, 1,3-dihydro-1-methyl-
  • Mercazolylum
  • N-Methyl-2-mercaptoimidazole
  • Thiamazolum
  • Tiamazolo
  • 1-Methylimidazole-2(3H)-thione
  • Imidazole-2-thiol, 1-methyl-
  • Mercaptizole
  • Felimazole
  • Methimazole (USP)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Leaflets from alcoholexp.
Odour
FAINT, CHARACTERISTICexp.
Melting point
146 to 148exp.
Boiling point
280 °Cexp.
Solubility
1 G SOL IN ABOUT 125 ML ETHER, ABOUT 4.5 ML CHLOROFORM, ABOUT 5 ML WATER, 5 ML ALCOHOLexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
114.17 g/molcalc.
Exact mass
114.0252 Dacalc.
LogP (octanol/water)
1.08calc.
Topological polar surface area
20.72 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
0calc.
Heavy atoms
7calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, S=c1[nH]cc[nH]1

S=c1[nH]cc[nH]1

1 ring, 6 atoms, the 2-Mercaptoimidazole ring system.

157 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H317May cause an allergic skin reaction.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (15)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Methimazole suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 131 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

131 suppliers in 18 countries

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Methimazole price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

In cyanide-free silver electroplating. THERAP CAT: Antihyperthyroid.

Use classes: Pharmaceuticals, Animal Drugs.

Pharmacological actions

  • Antithyroid Agents

Roles

  • antagonist
  • antithyroid drug
  • hormone antagonist
  • hormone receptor modulator
  • pharmaceutical
  • receptor modulator

Pharmacology

Methimazole is a Thyroid Hormone Synthesis Inhibitor. The mechanism of action of methimazole is as a Thyroid Hormone Synthesis Inhibitor.

How it is made

Prepd by treating aminoacetaldehyde diethyl acetal with methyl isothiocyanate, from thiocyanic acid & n-substituted amino acetals.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Thiamazole (INN), Ref no: 233, Annex ref: II/233
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Methimazole is traded under.

HS 2933.29Indicative HS code

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…

World exports in 2024
$1.43B
−7.6% vs 2023, imports $1.47B
2019 to 2024
Top exporters
  1. China28.1%
  2. France * partner reported12.7%
  3. India * partner reported10.3%
Top importers
  1. United Kingdom13.0%
  2. United States7.9%
  3. China6.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Methimazole is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Methimazole, based on the data on this page

What is Methimazole?

Methimazole is a member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen. It has a role as an antithyroid drug.

What is the CAS number of Methimazole?

The CAS registry number of Methimazole is 60-56-0. Other or deprecated CAS numbers: 223768-14-7, 85916-84-3.

What is the molecular formula and weight of Methimazole?

The molecular formula of Methimazole is C4H6N2S and its molar mass is 114.17 g/mol.

What is Methimazole used for?

In cyanide-free silver electroplating. THERAP CAT: Antihyperthyroid. Use classes: Pharmaceuticals, Animal Drugs.

Is Methimazole hazardous?

Methimazole carries the GHS signal word "Warning". Main hazards: harmful if swallowed, may cause an allergic skin reaction, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Methimazole?

Methimazole is usually classified under HS code 293329 (Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Methimazole?

CompoundList lists 131 suppliers of Methimazole in United States, China, India, Germany and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Methimazole in India?

11 suppliers in India list Methimazole on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Methimazole?

Suppliers quote Methimazole on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Methimazole

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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