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Central nervous system drugs

Methsuximide

Also known as Mesuximide, Celontin, 1,3-dimethyl-3-phenylpyrrolidine-2,5-dione

CAS 77-41-8Formula C12H13NO2Molar mass 203.24 g/molEC 201-026-7
GHS signal word: Warning. Pictograms: Harmful or irritant 12 suppliers listed Drug substance
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Methsuximide chemical structure, C12H13NO2, CAS 77-41-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from dilute alcohol
Melting point
52 to 53
Boiling point
121 to 122
Solubility
Slightly soluble in hot water, freely soluble in alcohol and ether, very soluble in chlo…
HS code
292519
Category
Central nervous system drugs
Illustrative photo, a shrink wrapped pallet of kraft paper sacks in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Methsuximide?

Plain description, key identifiers and synonyms

Methsuximide is an organic molecular entity.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1,3-dimethyl-3-phenylpyrrolidine-2,5-dione
CAS number
77-41-8 CAS number cross-checked
EC number
201-026-7
Molecular formula
C12H13NO2
UNII
0G76K8X6C0
MDL number
MFCD00072132
InChIKey
AJXPJJZHWIXJCJ-UHFFFAOYSA-N
InChI
InChI=1S/C12H13NO2/c1-12(9-6-4-3-5-7-9)8-10(14)13(2)11(12)15/h3-7H,8H2,1-2H3
SMILES (canonical and isomeric)
CC1(CC(=O)N(C1=O)C)C2=CC=CC=C2

Synonyms

  • Mesuximide
  • Celontin
  • 1,3-dimethyl-3-phenylpyrrolidine-2,5-dione
  • Methsuximid
  • Metsuccimide
  • Mesuximidum
  • mesuximid
  • alpha-Methylphensuximide
  • N,2-Dimethyl-2-phenylsuccinimide
  • 1,3-Dimethyl-3-phenylsuccinimide
  • Mesuximida
  • Metosuccimmide
  • 1,3-Dimethyl-3-phenyl-2,5-dioxopyrrolidine
  • 1,3-Dimethyl-3-phenyl-pyrrolidin-2,5-dione
  • 2,5-Pyrrolidinedione, 1,3-dimethyl-3-phenyl-
  • N-Methyl-alpha-methyl-alpha-phenylsuccinimide
  • alpha-Methyl-alpha-phenyl N-methyl succinimide
  • PM 396
  • (RS)-1,3-Dimethyl-3-phenyl-2,5-pyrrolidindion
  • Succinimide, N,2-dimethyl-2-phenyl-
  • Methsuximide (USP)
  • Petinutin
  • 1,3-Dimethyl-3-phenyl-2,5-pyrrolidinedione
  • Mesuximide (INN)
  • Celontin (TN)
Show all 30 synonyms
  • (+-)-N,2-Dimethyl-2-phenylsuccinimide
  • Mesuximide, Celontin
  • Methsuximide (Standard)
  • 1,3-Dimethyl-3-phenyl-pyrrolidine-2,5-dione
  • 2,5-Pyrrolidinedione,1,3-dimethyl-3-phenyl-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from dilute alcoholexp.
Odour
Odorless to slight odorexp.
Melting point
52 to 53exp.
Boiling point
121 to 122exp.
Solubility
Slightly soluble in hot water, freely soluble in alcohol and ether, very soluble in chloroform.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
203.24 g/molcalc.
Exact mass
203.0946 Dacalc.
LogP (octanol/water)
1.33calc.
Topological polar surface area
37.38 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
15calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CC(c2ccccc2)C(=O)N1

O=C1CC(c2ccccc2)C(=O)N1

2 rings, 13 atoms, the 3-Phenylpyrrolidine-2,5-dione ring system.

183 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H412Harmful to aquatic life with long lasting effects.
Precautionary statements (6)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Methsuximide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 12 suppliers
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Where suppliers are based

12 suppliers in 6 countries

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Methsuximide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Anticonvulsant.

Anticonvulsant succinimide.

Industries and functions

Pharmacological actions

  • Anticonvulsants

Roles

  • anticonvulsant
  • central nervous system depressant
  • central nervous system drug
  • pharmaceutical

Pharmacology

Methsuximide is an Anti-epileptic Agent. The physiologic effect of methsuximide is by means of Decreased Central Nervous System Disorganized Electrical Activity.

How it is made

2-methyl-2-phenylsuccinic acid is dissolved in excess of 40% methylamine. Water & excess amine are distilled off & residue consisting of di(methylamine) salt of acid is pyrolized at about 250 °C until no more distillate is formed. Residue of crude methsuximide may be purified by vacuum dist or by...precipitation...

Prepd by action of methylamine on alpha-methyl-alpha-phenylsuccinic acid.

Acetophenone + ethyl cyanoacetate + hydrogen cyanide + methylamine (Cope reaction/addition/nitrile hydrolysis/decarboxylation/amide formation).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Methsuximide is traded under.

HS 2925.19Indicative HS code

Imides and their derivatives, salts thereof, other

World exports in 2024
$295M
+11.7% vs 2023, imports $348M
2019 to 2024
Top exporters
  1. China29.7%
  2. Japan22.7%
  3. United Kingdom10.0%
Top importers
  1. United States12.7%
  2. Brazil12.6%
  3. China10.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Methsuximide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Methsuximide, based on the data on this page

What is Methsuximide?

Methsuximide is an organic molecular entity.

What is the CAS number of Methsuximide?

The CAS registry number of Methsuximide is 77-41-8.

What is the molecular formula and weight of Methsuximide?

The molecular formula of Methsuximide is C12H13NO2 and its molar mass is 203.24 g/mol.

What is Methsuximide used for?

Anticonvulsant. Anticonvulsant succinimide.

Is Methsuximide hazardous?

Methsuximide carries the GHS signal word "Warning". Main hazards: harmful if swallowed, harmful to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Methsuximide?

Methsuximide is usually classified under HS code 292519 (Imides and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Methsuximide?

CompoundList lists 12 suppliers of Methsuximide in United States, China, Switzerland, Germany and 2 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Methsuximide in India?

1 supplier in India list Methsuximide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Methsuximide?

Suppliers quote Methsuximide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Methsuximide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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