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Impurities and reference standards

Methyldihydrocodeine

Also known as Tetrahydrothebaine, Codeine, methyldihydro-, Morphinan, 3,6-alpha-dimethoxy-4,5-alpha-epoxy-17-methyl-

CAS 33049-61-5Formula C19H25NO3Molar mass 315.41 g/mol
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Methyldihydrocodeine chemical structure, C19H25NO3, CAS 33049-61-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
33049-61-5
Formula
C19H25NO3
Molar mass
315.41 g/mol
HS code
293499
Category
Impurities and reference standards

What is Methyldihydrocodeine?

Plain description, key identifiers and synonyms

Methyldihydrocodeine is a chemical substance with the molecular formula C19H25NO3 and a molar mass of 315.41 g/mol. Its CAS registry number is 33049-61-5. The IUPAC name is (4R,4aR,7S,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R,4aR,7S,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline
CAS number
33049-61-5 CAS number cross-checked
Molecular formula
C19H25NO3
UNII
J0I03TC85M
InChIKey
RVJQWONQPCTLDL-SSTWWWIQSA-N
InChI
InChI=1S/C19H25NO3/c1-20-9-8-19-12-5-7-15(22-3)18(19)23-17-14(21-2)6-4-11(16(17)19)10-13(12)20/h4,6,12-13,15,18H,5,7-10H2,1-3H3/t12-,13+,15-,18-,19-/m0/s1
Canonical SMILES
COc1ccc2c3c1OC1C(OC)CCC4C(C2)N(C)CCC341
Isomeric SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](CC4)OC

Synonyms

  • Tetrahydrothebaine
  • Codeine, methyldihydro-
  • Morphinan, 3,6-alpha-dimethoxy-4,5-alpha-epoxy-17-methyl-
  • o-Methyldihydrocodeine
  • Morphinan, 4,5alpha-epoxy-3,6alpha-dimethoxy-17-methyl-
  • 7,8-Dihydro-o-methylcodeine
  • (4R,4aR,7S,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline
  • Dihydrocodeine Hydrogen Tartrate EP Impurity D
  • 3,6alpha-Dimethoxy-17-methyl-5alpha-4,5-epoxymorphinan
  • Dihydrocodeine hydrogen tartrate impurity d
  • Hydrocodone hydrogen tartrate 2.5-hydrate impurity g
  • Morphinan, 4,5-epoxy-3,6-dimethoxy-17-methyl-, (5alpha,6.alpha.)-
  • (4R,4aR,7S,7aR,12bS)-7,9-dimethoxy-3-methyl-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
315.41 g/molcalc.
Exact mass
315.1834 Dacalc.
LogP (octanol/water)
2.38calc.
Topological polar surface area
30.93 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
23calc.
Rings
5calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.68calc.
Formal charge
0calc.
Stereocentres
5calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc2c3c(c1)OC1CCCC4C(C2)NCCC314

c1cc2c3c(c1)OC1CCCC4C(C2)NCCC314

5 rings, 18 atoms.

110 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Methyldihydrocodeine suppliers

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Methyldihydrocodeine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Methyldihydrocodeine is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Methyldihydrocodeine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Methyldihydrocodeine, based on the data on this page

What is Methyldihydrocodeine?

Methyldihydrocodeine is a chemical substance with the molecular formula C19H25NO3 and a molar mass of 315.41 g/mol. Its CAS registry number is 33049-61-5. The IUPAC name is (4R,4aR,7S,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline.

What is the CAS number of Methyldihydrocodeine?

The CAS registry number of Methyldihydrocodeine is 33049-61-5.

What is the molecular formula and weight of Methyldihydrocodeine?

The molecular formula of Methyldihydrocodeine is C19H25NO3 and its molar mass is 315.41 g/mol.

Is Methyldihydrocodeine hazardous?

No GHS hazard classification for Methyldihydrocodeine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Methyldihydrocodeine?

Methyldihydrocodeine is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Methyldihydrocodeine?

Post a free request on CompoundList and suppliers of Methyldihydrocodeine will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Methyldihydrocodeine?

Suppliers quote Methyldihydrocodeine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Methyldihydrocodeine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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